Results 1 to 10 of about 1,899,709 (278)

Genomics of human longevity [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences on human longevity are expected to be much more complex.
Slagboom, P.E., Beekman, M., Passtoors, W.M., Deelen, J., Vaarhorst, A.A.M., Boer, J.M., Akker, E.B. van den, Heemst, D. van, Craen, A.J.M. de, Maier, A.B., Rozing, M., Mooijaart, S.P., Heijmans, B.T., Westendorp, R.G.J.   +13 more
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The Sequence of the Human Genome [PDF]

Science, 2001
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of ...
Venter, J. Craig, Adams, Mark, Myers, Eugene, Li, Peter, Mural, Richard, Sutton, Granger, Smith, Hamilton, Yandell, Mark, Evans, Cheryl, Holt, Robert, Gocayne, Jeannine, Amanatides, Peter, Ballew, Richard, Huson, Daniel, Wortman, Jennifer Russo, Zhang, Qing, Kodira, Chinnappa, Zheng, Xiangqun, Chen, Lin, Skupski, Marian, Subramanian, Gangadharan, Thomas, Paul, Zhang, Jinghui, Gabor Miklos, George, Nelson, Catherine, Broder, Samuel, Clark, Andrew, Nadeau, Joe, Mckusick, Victor, Zinder, Norton, Levine, Arnold, Roberts, Richard, Simon, Mel, Slayman, Carolyn, Hunkapiller, Michael, Bolanos, Randall, Delcher, Arthur, Dew, Ian, Fasulo, Daniel, Flanigan, Michael, Florea, Liliana, Halpern, Aaron, Hannenhalli, Sridhar, Kravitz, Saul, Levy, Samuel, Mobarry, Clark, Reinert, Knut, Remington, Karin, Abu-Threideh, Jane, Beasley, Ellen, Biddick, Kendra, Bonazzi, Vivien, Brandon, Rhonda, Cargill, Michele, Chandramouliswaran, Ishwar, Charlab, Rosane, Chaturvedi, Kabir, Deng, Zuoming, Francesco, Valentina Di, Dunn, Patrick, Eilbeck, Karen, Evangelista, Carlos, Gabrielian, Andrei, Gan, Weiniu, Ge, Wangmao, Gong, Fangcheng, Gu, Zhiping, Guan, Ping, Heiman, Thomas, Higgins, Maureen, Ji, Rui-Ru, Ke, Zhaoxi, Ketchum, Karen, Lai, Zhongwu, Lei, Yiding, Li, Zhenya, Li, Jiayin, Liang, Yong, Lin, Xiaoying, Lu, Fu, Merkulov, Gennady, Milshina, Natalia, Moore, Helen, Naik, Ashwinikumar, Narayan, Vaibhav, Neelam, Beena, Nusskern, Deborah, Rusch, Douglas, Salzberg, Steven, Shao, Wei, Shue, Bixiong, Sun, Jingtao, Wang, Zhen Yuan, Wang, Aihui, Wang, Xin, Wang, Jian, Wei, Ming-Hui, Wides, Ron, Xiao, Chunlin, Yan, Chunhua, Yao, Alison, Ye, Jane, Zhan, Ming, Zhang, Weiqing, Zhang, Hongyu, Zhao, Qi, Zheng, Liansheng, Zhong, Fei, Zhong, Wenyan, Zhu, Shiaoping, Zhao, Shaying, Gilbert, Dennis, Baumhueter, Suzanna, Spier, Gene, Carter, Christine, Cravchik, Anibal, Woodage, Trevor, Ali, Feroze, An, Huijin, Awe, Aderonke, Baldwin, Danita, Baden, Holly, Barnstead, Mary, Barrow, Ian, Beeson, Karen, Busam, Dana, Carver, Amy, Center, Angela, Cheng, Ming Lai, Curry, Liz, Danaher, Steve, Davenport, Lionel, Desilets, Raymond, Dietz, Susanne, Dodson, Kristina, Doup, Lisa, Ferriera, Steven, Garg, Neha, Gluecksmann, Andres, Hart, Brit, Haynes, Jason, Haynes, Charles, Heiner, Cheryl, Hladun, Suzanne, Hostin, Damon, Houck, Jarrett, Howland, Timothy, Ibegwam, Chinyere, Johnson, Jeffery, Kalush, Francis, Kline, Lesley, Koduru, Shashi, Love, Amy, Mann, Felecia, May, David, Mccawley, Steven, Mcintosh, Tina, Mcmullen, Ivy, Moy, Mee, Moy, Linda, Murphy, Brian, Nelson, Keith, Pfannkoch, Cynthia, Pratts, Eric, Puri, Vinita, Qureshi, Hina, Reardon, Matthew, Rodriguez, Robert, Rogers, Yu-Hui, Romblad, Deanna, Ruhfel, Bob, Scott, Richard, Sitter, Cynthia, Smallwood, Michelle, Stewart, Erin, Strong, Renee, Suh, Ellen, Thomas, Reginald, Tint, Ni Ni, Tse, Sukyee, Vech, Claire, Wang, Gary, Wetter, Jeremy, Williams, Sherita, Williams, Monica, Windsor, Sandra, Winn-Deen, Emily, Wolfe, Keriellen, Zaveri, Jayshree, Zaveri, Karena, Abril, Josep, Guigó, Roderic, Campbell, Michael, Sjolander, Kimmen, Karlak, Brian, Kejariwal, Anish, Mi, Huaiyu, Lazareva, Betty, Hatton, Thomas, Narechania, Apurva, Bafna, Vineet, Schwartz, Russell, Yooseph, Shibu, Mays, Anne Deslattes, Harris, Michael   +204 more
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Expressing the human genome [PDF]

Nature, 2001
We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared
TUPLER, Rossella, G. PERINI G., M. R. GREEN   +2 more
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The Human Genome [PDF]

Briefings in Bioinformatics, 2002
The total genetic complement of our species is called “human genome”. It comprises a set of different DNA molecules, corresponding to 25 different types of chromosomes (22 autosomes, X chromosome, Y chromosome, mitochondrial DNA) which are present within our cells.
A. Rosenthal, L. Vakalopoulou
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Genomics and human diversity [PDF]

Cahiers de l’Urmis, 2021
The sequencing of the human genome (2003) has been followed by a number of technical developments that allow detailed characterization (including complete sequencing) of the DNA of thousands of individuals. This has provided an estimate of human genetic diversity: approx. 3 million base substitutions within our genome that includes 3,000 million bases.
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Sequencing the Human Genome [PDF]

Science, 1986
The title of the report by R. Myerowitz and N. Hogikyan on page 1646 of the issue of 27 June was incorrect. It should have been "Different mutations in Ashkenazi Jews and non-Jewish French Canadians with Tay-Sachs disease."
James Bruce Walsh, Jon Marks
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The genomics of the human endometrium

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
The endometrium is a complex tissue that lines the inside of the endometrial cavity. The gene expression of the different endometrial cell types is regulated by ovarian steroids and paracrine-secreted molecules from neighbouring cells. Due to this regulation, the endometrium goes through cyclic modifications which can be divided simply into the ...
Carlos Simón, Maria Ruiz-Alonso, David Blesa   +2 more
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On the sequencing of the human genome [PDF]

Proceedings of the National Academy of Sciences, 2002
Two recent papers using different approaches reported draft sequences of the human genome. The international Human Genome Project (HGP) used the hierarchical shotgun approach, whereas Celera Genomics adopted the whole-genome shotgun (WGS) approach. Here, we analyze whether the latter paper provides a meaningful test of the WGS approach on a mammalian ...
Waterston, Robert H., Lander, Eric S., Sulston, John E.   +2 more
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Human genome regulation [PDF]

Bioengineered, 2016
In the early 90s, Manfred Eigen lectured at Hoffman-La Roche and explained that a gene of 1,000 base pairs has 10605 combinations.
Christian Bach, Prabir Patra
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Changes in Human Genomics [PDF]

Human Genomics, 2011
I would like to welcome you to the second issue of Volume 5 and also to announce several changes to the Journal including new members of our Editorial Board, the introduction of a new section 'Research Highlights' and, crucially, the introduction of open-access papers.
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