Results 11 to 20 of about 2,011,170 (298)
Genomics of human longevity [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences on human longevity are expected to be much more complex.Slagboom, P.E., Beekman, M., Passtoors, W.M., Deelen, J., Vaarhorst, A.A.M., Boer, J.M., Akker, E.B. van den, Heemst, D. van, Craen, A.J.M. de, Maier, A.B., Rozing, M., Mooijaart, S.P., Heijmans, B.T., Westendorp, R.G.J. +13 moreopenaire +8 more sourcesThe Sequence of the Human Genome [PDF]
Science, 2001 A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of ...Venter, J. Craig, Adams, Mark, Myers, Eugene, Li, Peter, Mural, Richard, Sutton, Granger, Smith, Hamilton, Yandell, Mark, Evans, Cheryl, Holt, Robert, Gocayne, Jeannine, Amanatides, Peter, Ballew, Richard, Huson, Daniel, Wortman, Jennifer Russo, Zhang, Qing, Kodira, Chinnappa, Zheng, Xiangqun, Chen, Lin, Skupski, Marian, Subramanian, Gangadharan, Thomas, Paul, Zhang, Jinghui, Gabor Miklos, George, Nelson, Catherine, Broder, Samuel, Clark, Andrew, Nadeau, Joe, Mckusick, Victor, Zinder, Norton, Levine, Arnold, Roberts, Richard, Simon, Mel, Slayman, Carolyn, Hunkapiller, Michael, Bolanos, Randall, Delcher, Arthur, Dew, Ian, Fasulo, Daniel, Flanigan, Michael, Florea, Liliana, Halpern, Aaron, Hannenhalli, Sridhar, Kravitz, Saul, Levy, Samuel, Mobarry, Clark, Reinert, Knut, Remington, Karin, Abu-Threideh, Jane, Beasley, Ellen, Biddick, Kendra, Bonazzi, Vivien, Brandon, Rhonda, Cargill, Michele, Chandramouliswaran, Ishwar, Charlab, Rosane, Chaturvedi, Kabir, Deng, Zuoming, Francesco, Valentina Di, Dunn, Patrick, Eilbeck, Karen, Evangelista, Carlos, Gabrielian, Andrei, Gan, Weiniu, Ge, Wangmao, Gong, Fangcheng, Gu, Zhiping, Guan, Ping, Heiman, Thomas, Higgins, Maureen, Ji, Rui-Ru, Ke, Zhaoxi, Ketchum, Karen, Lai, Zhongwu, Lei, Yiding, Li, Zhenya, Li, Jiayin, Liang, Yong, Lin, Xiaoying, Lu, Fu, Merkulov, Gennady, Milshina, Natalia, Moore, Helen, Naik, Ashwinikumar, Narayan, Vaibhav, Neelam, Beena, Nusskern, Deborah, Rusch, Douglas, Salzberg, Steven, Shao, Wei, Shue, Bixiong, Sun, Jingtao, Wang, Zhen Yuan, Wang, Aihui, Wang, Xin, Wang, Jian, Wei, Ming-Hui, Wides, Ron, Xiao, Chunlin, Yan, Chunhua, Yao, Alison, Ye, Jane, Zhan, Ming, Zhang, Weiqing, Zhang, Hongyu, Zhao, Qi, Zheng, Liansheng, Zhong, Fei, Zhong, Wenyan, Zhu, Shiaoping, Zhao, Shaying, Gilbert, Dennis, Baumhueter, Suzanna, Spier, Gene, Carter, Christine, Cravchik, Anibal, Woodage, Trevor, Ali, Feroze, An, Huijin, Awe, Aderonke, Baldwin, Danita, Baden, Holly, Barnstead, Mary, Barrow, Ian, Beeson, Karen, Busam, Dana, Carver, Amy, Center, Angela, Cheng, Ming Lai, Curry, Liz, Danaher, Steve, Davenport, Lionel, Desilets, Raymond, Dietz, Susanne, Dodson, Kristina, Doup, Lisa, Ferriera, Steven, Garg, Neha, Gluecksmann, Andres, Hart, Brit, Haynes, Jason, Haynes, Charles, Heiner, Cheryl, Hladun, Suzanne, Hostin, Damon, Houck, Jarrett, Howland, Timothy, Ibegwam, Chinyere, Johnson, Jeffery, Kalush, Francis, Kline, Lesley, Koduru, Shashi, Love, Amy, Mann, Felecia, May, David, Mccawley, Steven, Mcintosh, Tina, Mcmullen, Ivy, Moy, Mee, Moy, Linda, Murphy, Brian, Nelson, Keith, Pfannkoch, Cynthia, Pratts, Eric, Puri, Vinita, Qureshi, Hina, Reardon, Matthew, Rodriguez, Robert, Rogers, Yu-Hui, Romblad, Deanna, Ruhfel, Bob, Scott, Richard, Sitter, Cynthia, Smallwood, Michelle, Stewart, Erin, Strong, Renee, Suh, Ellen, Thomas, Reginald, Tint, Ni Ni, Tse, Sukyee, Vech, Claire, Wang, Gary, Wetter, Jeremy, Williams, Sherita, Williams, Monica, Windsor, Sandra, Winn-Deen, Emily, Wolfe, Keriellen, Zaveri, Jayshree, Zaveri, Karena, Abril, Josep, Guigó, Roderic, Campbell, Michael, Sjolander, Kimmen, Karlak, Brian, Kejariwal, Anish, Mi, Huaiyu, Lazareva, Betty, Hatton, Thomas, Narechania, Apurva, Bafna, Vineet, Schwartz, Russell, Yooseph, Shibu, Mays, Anne Deslattes, Harris, Michael +204 moreopenaire +6 more sourcesExpressing the human genome [PDF]
Nature, 2001 We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared TUPLER, Rossella, G. PERINI G., M. R. GREEN +2 moreopenaire +2 more sourcesThe Human Genome [PDF]
Briefings in Bioinformatics, 2002 The total genetic complement of our species is called “human genome”. It comprises a set of different DNA molecules, corresponding to 25 different types of chromosomes (22 autosomes, X chromosome, Y chromosome, mitochondrial DNA) which are present within our cells.A. Rosenthal, L. Vakalopoulou +9 more sourcesGenomics and human diversity [PDF]
Cahiers de l’Urmis, 2021 The sequencing of the human genome (2003) has been followed by a number of technical developments that allow detailed characterization (including complete sequencing) of the DNA of thousands of individuals. This has provided an estimate of human genetic diversity: approx. 3 million base substitutions within our genome that includes 3,000 million bases. openaire +2 more sourcesPlasmodium knowlesi Genome Sequences from Clinical Isolates Reveal Extensive Genomic Dimorphism. [PDF]
, 2015 Plasmodium knowlesi is a newly described zoonosis that causes malaria in the human population that can be severe and fatal. The study of P. knowlesi parasites from human clinical isolates is relatively new and, in order to obtain maximum information from A Conesa, A Ecker, A Pain, A Sinha, AR Quinlan, B Langmead, B Singh, B Singh, C Aurrecoechea, C Daneshvar, C Hertz-Fowler, CJ Sutherland, EV Meyer, FA Fatih, H Li, I Kozarewa, J Cox-Singh, J Cox-Singh, Janet Cox-Singh, JB Koenderink, JC Barrett, JC Barrett, JC de Roode, JC Rayner, Julian C. Rayner, K Rutherford, KS Lee, L Mamanova, LH Miller, LH Miller, M Ashburner, M Rougemont, M Yuda, MA Ahmed, Md Atique Ahmed, Miguel M. Pinheiro, Osamu Kaneko, P Jones, P Librado, PC Divis, PM Jones, R Leinonen, R Tanizaki, R Tripathi, S Iwanaga, S Purcell, Sanjeev Krishna, Scott B. Millar, SE Lindner, SO Oyola, SW Roy, T Carver, T William, TC Yeo, Theo Sanderson, Thomas D. Otto, U Bronner, Woon Chan Lu, YL Lau +58 morecore +4 more sourcesGenetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
Nature Communications, 2021 PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are ...Stephen Watt, Louella Vasquez, Klaudia Walter, Alice L. Mann, Kousik Kundu, Lu Chen, Ying Sims, Simone Ecker, Frances Burden, Samantha Farrow, Ben Farr, Valentina Iotchkova, Heather Elding, Daniel Mead, Manuel Tardaguila, Hannes Ponstingl, David Richardson, Avik Datta, Paul Flicek, Laura Clarke, Kate Downes, Tomi Pastinen, Peter Fraser, Mattia Frontini, Biola-Maria Javierre, Mikhail Spivakov, Nicole Soranzo +26 moredoaj +1 more sourceFunctional analysis and transcriptional output of the Göttingen minipig genome [PDF]
, 2015 In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism.Badi, Laura, Berrera, Marco, Bishop, Richard, Certa, Ulrich, Daff, Hamina, Daubenberger, Claudia, Ebeling, Martin, Heckel, Tobias, Khan, Azinwi Phina, Kiialainen, Anna, Kratochwil, Nicole A., Kuhn, Bernd, Küng, Erich, Lekolool, Isaac, Nowaczyk, Corinne, Okoth, Edward, Pelle, Roger, Ravon, Morgane, Ringshandl, Stephan, Schmitt, Georg, Schmucki, Roland, Steiner, Guido +21 morecore +9 more sourcesSVachra: a tool to identify genomic structural variation in mate pair sequencing data containing inward and outward facing reads
BMC Genomics, 2017 Background Characterization of genomic structural variation (SV) is essential to expanding the research and clinical applications of genome sequencing.Oliver A. Hampton, Adam C. English, Mark Wang, William J. Salerno, Yue Liu, Donna M. Muzny, Yi Han, David A. Wheeler, Kim C. Worley, James R. Lupski, Richard A. Gibbs +10 moredoaj +1 more sourceMeasuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model. [PDF]
, 2012 Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection.Buschiazzo, Emmanuel, Gemmell, Neil, Lennon, Dustin, Minin, Vladimir N, Sawaya, Sterling M +4 morecore +1 more source
