Results 201 to 210 of about 2,067,653 (305)

P618: Misuse of opportunistic screening highlights shortcomings in clinical ascertainment

Genetics in Medicine Open
Julie Sapp, Leslie Biesecker, Jennifer Johnston, Katie Lewis   +3 more
doaj   +1 more source

Integrating the Data From Microbiome and Metabolome Genome-Wide Association Studies to Uncover Gene-Microbe-Metabolite Interactions in Allergic Diseases. [PDF]

Cureus
Yuan Y, Tang Y, Sun Y.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Genetic Diversity of Tick-Borne Encephalitis Virus in Kyrgyzstan. [PDF]

Viruses
Shigapova LH, Kozlova IV, Klink GV, Doroshchenko EK, Suntsova OV, Lisak OV, Shagimardanova EI, Dzhioev YP, Zlobin VI, Tkachev SE.   +9 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The 3D Genome Browser 2.0: an enhanced online platform for visualizing and analyzing 3D genome architecture. [PDF]

Nucleic Acids Res
Yu S, Fu Y, Wong JH, Wang J, Zhao H, Zhao J, Yue F.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Updated analysis of pathogenic variants in BRCA1/BRCA2 among the general Japanese population. [PDF]

Hum Genome Var
Mariya T, Idogawa M, Saito T, Nakase H, Tokino T, Sakurai A.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source