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Primer on the human genome

Journal of the American Academy of Dermatology, 2007
The study of the expression patterns of many genes, or even the entire genome, is now routinely possible. Such powerful tools have enabled hypothesis-generating research at a scale never before possible. Moreover, spatially or temporally linked gene and protein expression, implying co-regulation and functional relatedness, has led to the identification
Kenneth Y, Tsai, Hensin, Tsao
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Illuminating the human genome

Histochemistry and Cell Biology, 2000
The identification and analysis of novel genes and their encoded protein products remains a vigorous area of research in biology today. Worldwide genomic and cDNA sequencing projects are now identifying new molecules every day and the need for methodologies to functionally characterise these proteins has never been greater.
Simpson, Jeremy C   +3 more
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SNPing in the human genome

Current Opinion in Chemical Biology, 2001
More than a million genetic markers in the form of single nucleotide polymorphisms are now available for use in genotype-phenotype studies in humans. The application of new strategies for representational cloning and sequencing from genomes combined with the mining of high-quality sequence variations in clone overlaps of genomic and/or cDNA sequences ...
C S, Carlson   +2 more
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Organization of the human genome

Journal of Inherited Metabolic Disease, 1994
SummaryThe human genome contains about 3×109 base pairs which, based on average estimates for the size of coding regions, might suggest an upper limit of about 3 million genes. Evidence from a variety of approaches indicates a much lower figure — in the range 40 000–100 000 genes.
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Accessing the Human Genome

Current Protocols in Human Genetics, 2002
AbstractThe majority of the sequence for the human genome is now available. Regardless of the researcher's area of interest, it is quite likely that they will want to use some aspect of this data. This unit helps researchers achieve that goal. It presents the gene models available at NCBI, the UCSC Genome Browser, and Ensembl.
Deanna, Church, Kim D, Pruitt
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Mapping the Human Genome

The Hastings Center Report, 1989
Mapping the Human Genome From early morning until late afternoon of the 24th through the 26th of October, 1988, scientists from some twenty-four countries met in Valencia to discuss the present status and future prospects of the Human Genome Project. The media's extensive coverage of the meeting at the time gave an indication of the widespread interest
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Archaic human genomics

American Journal of Physical Anthropology, 2012
AbstractFor much of the 20th century, the predominant view of human evolutionary history was derived from the fossil record. Homo erectus was seen arising in Africa from an earlier member of the genus and then spreading throughout the Old World and into the Oceania. A regional continuity model of anagenetic change from H.
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Mapping the human genome

2020
The haploid human genome contains approximately 70,000 different genes in its 3200 megabases of chromosomal DNA. High resolution maps of all chromosomes are urgently required both for functional analysis of the genome as a whole and for the identification and characterization of its constituent gene sequences.
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Ownership and the human genome

Nature, 1994
Unexpectedly rapid progress towards the sequencing and listing of the genes in the human genome has caused a flurry of excitement (and injured pride) in the genome community which is likely to surface in Washington next week.
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Interventions in the Human Genome

The Modern Law Review, 1998
dictators, the recent eugenic excesses of the twentieth century and the brave new world held out by the imminent completion of the Human Genome Project provide rich and fertile ground for speculation, debate and sometimes concern. On the other hand, genetics offers the capacity to identify disorders and hopefully in the future to cure them.
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