Results 231 to 240 of about 2,078,242 (303)

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Draft genome sequences of <i>Lactiplantibacillus plantarum</i> strains KABP062 and KABP063 isolated from human feces. [PDF]

Microbiol Resour Announc
Huedo P, Astó E, Perez M, Rodriguez-Palmero M, Espadaler-Mazo J.   +4 more
europepmc   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Draft genome sequence of <i>Kosakonia oralis</i> 282A-S69, a novel member of the genus <i>Kosakonia</i> isolated from the human oral cavity. [PDF]

Microbiol Resour Announc
Khan RA, Bhagawati M, Jose RC, Sarmah R.
europepmc   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Why Should a Genome Be Protected? Ethical, Legal, and Security Challenges in the Protection of Genomic Data. [PDF]

Biology (Basel)
Szalata M, Danielewski M, Wielgus K, Słomski R.   +3 more
europepmc   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

O26: Analysis of patient-reported outcomes and a functional assessment from 3-year nitisinone treatment trial in patients with alkaptonuria

Genetics in Medicine Open
Kathryn Spears, Francis Rossignol, Monique Perry, Joy Bryant, William Gahl, Wendy Introne   +5 more
doaj   +1 more source

Human astrovirus draft genomes from under-five children presenting with gastroenteritis in Malawi from 2012 to 2024. [PDF]

Microbiol Resour Announc
Matambo E, Kawonga F, Mhango C, Chinyama E, Msowoya J, Majengo C, Ogunbayo AE, Shange N, Sondlane H, Mogotsi MT, Dennis FE, Matambo PB, Kamng'ona AW, Kumwenda B, Nyaga MM, Donato CM, Chaguza C, Jere KC.   +17 more
europepmc   +1 more source