Results 231 to 240 of about 10,751,278 (348)

Further varieties of ancient endogenous retrovirus in human DNA. [PDF]

Mob DNA
Frith MC.
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Regulatory Plasticity of the Human Genome. [PDF]

Mol Biol Evol
Srivastava J, Ovcharenko I.
europepmc   +1 more source

Ethical consequences of full human genome testing [PDF]

, 2017
Lupton, Michael
core   +2 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases. [PDF]

BMC Genomics
Wang C, Cheng Z, Miao J, Xue X, Dong Y, Zhao L, Guo H, Wang J, Wang Z, Lu S, Fang G, Peng Y, Zhai Y, Zhang Z, Gao D, Wang Z, Wang P, Zhang L, Dunmall LSC, Wang J, Tang W, Li X, Ding Z, Zhao X, Li L, Lemoine NR, Wang Z, Tonge D, Tan W, Dong J, Wang Y.   +30 more
europepmc   +1 more source

Genome-wide methylation profiles reveal quantitative views of human aging rates.

Molecules and Cells, 2013
G. Hannum, J. Guinney, Ling Zhao, Li Zhang, G. Hughes, S. Sadda, Brandy Klotzle, M. Bibikova, Jian-Bing Fan, Yuan Gao, Rob Deconde, Menzies Chen, I. Rajapakse, S. Friend, T. Ideker, Kang Zhang   +15 more
semanticscholar   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source