mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences [PDF]
, 2017 The mitochondrial genome, contained in the subcellular mitochondrial network, encodes a small number of peptides pivotal for cellular energy production.
Gyllensten, Ulf, Ingman, Max
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The complete mitochondrial genome of Hericium coralloides (Hericiaceae, Basidiomycota)
Mitochondrial DNA. Part B. Resources, 2017 In this study, the complete mitochondrial genome of the medicinal mushroom Hericium coralloides (Hericiaceae, Basidiomycota) was sequenced. This mitochondrial genome is 72,961 bp in length and consisted of 14 protein-coding genes, 21 hypothetical open ...
Caixia Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The complete mitochondrial genome of the Chilotilapia rhoadesii
Mitochondrial DNA. Part B. Resources, 2017 In this study, we firstly reported the complete mitochondrial genome of Chilotilapia rhoadesii. The whole mitochondrial genome is 16,580 bp in length, including 2 ribosomal RNA genes, 22 transfer RNA genes and 13 protein-coding genes.
Xiangru Wen +4 more
doaj +1 more source
Survey of Human Mitochondrial Diseases Using New Genomic/Proteomic Tools [PDF]
, 2001 BACKGROUND. We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human ...
Mohr, Scott C. +2 more
core +2 more sources
On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei [PDF]
, 2014 Background: Although technical advances in genomics and proteomics research have yielded a better understanding of the coding capacity of a genome, one major challenge remaining is the identification of all expressed proteins, especially those less than ...
Butter, F. +5 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The bipartite mitochondrial genome of Ruizia karukerae (Rhigonematomorpha, Nematoda)
Scientific Reports, 2018 Mitochondrial genes and whole mitochondrial genome sequences are widely used as molecular markers in studying population genetics and resolving both deep and shallow nodes in phylogenetics.
Taeho Kim +5 more
doaj +1 more source
Amended diagnosis, mitochondrial genome, and phylogenetic position of Sphyranura euryceae (Neodermata, Monogenea, Polystomatidae), a parasite of the Oklahoma salamander. [PDF]
Parasite, 2023 Leeming SJ +5 more
europepmc +1 more source