Results 101 to 110 of about 363,946 (316)

Plant Genomics: Sequencing and Understanding the Plant Genome

In an era marked by rapid environmental change and the urgent need for sustainable practices, the role of plants in our ecosystem and society has never been more critical. "The Future of Flora: Novel Research Driving Plant Innovation" explores the cutting-edge research and innovative approaches that are redefining our understanding of plants and their ...
Waoo, Ashwini A., Rai, Piyush Kant
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

An overall presentation of the T cell receptor (TR) genomics in Camelidae: future perspectives through Illumina sequencing in Camelus dromedarius

, 2020
Here we review the structural characteristics and the current status of the detailed genomic organization of α/ β and γ/δ T cell receptors (TRs) loci in the Camelus genus.
Rachele Antonacci, Pamela A. Burger, Salvatrice Ciccarese, Serafina Massari, Giovanna Linguiti, Elena Ciani   +5 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Terzyme: a tool for identification and analysis of the plant terpenome

Plant Methods, 2018
Background Terpenoid hydrocarbons represent the largest and most ancient group of phytochemicals, such that the entire chemical library of a plant is often referred to as its ‘terpenome’.
Piyush Priya, Archana Yadav, Jyoti Chand, Gitanjali Yadav   +3 more
doaj   +1 more source

The Repetitive Landscape of the Barley Genome [PDF]

, 2018
While transposable elements (TEs) comprise the bulk of plant genomic DNA, how they contribute to genome structure and organization is still poorly understood.
Alan H. Schulman, Thomas Wicker, Wicker, Thomas, Schulman, Alan Howard, Gundlach, Heidrun, Heidrun Gundlach   +5 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A CRISPR-Cas9 library to target putative redundant gene sets facilitates their functional exploration in grain development in rice

BMC Plant Biology
Advent of CRISPR-Cas9 library approach has revolutionized the field of high throughput targeted mutagenesis in plants. By identifying an sgRNA spacer that can target multiple paralogous genes in a genome, higher-order knockout plants can be developed ...
Banita Yadav, Shaswati Sardar, Anil Yadav, Annapurna Kumari, Mohini Gautam, Rushil Mandlik, Simran Arora, Shailesh Kumar, Pawan Kumar Jewaria, Humira Sonah, Rupesh Deshmukh, Viswanathan Chinnusamy, Hasthi Ram   +12 more
doaj   +1 more source

Plant Genome Engineering for Targeted Improvement of Crop Traits

, 2019
To improve food security, plant biology research aims to improve crop yield and tolerance to biotic and abiotic stress, as well as increasing the nutrient contents of food. Conventional breeding systems have allowed breeders to produce improved varieties
Mahfouz, Magdy M., Mahas, Ahmed, Sedeek, Khalid E. M.   +2 more
core   +1 more source

Centrophilic Retrotransposons of Plant Genomes

Annual Review of Plant Biology
The centromeres of eukaryotic chromosomes are required to load CENH3/CENP-A variant nucleosomes and the kinetochore complex, which connects to spindle microtubules during cell division. Despite their conserved function, plant centromeres show rapid sequence evolution within and between species and a range of monocentric, holocentric, and ...
Bousios, Alexandros, Kakutani, Tetsuji, Henderson, Ian R.   +2 more
openaire   +4 more sources