Results 81 to 90 of about 363,946 (316)
Evolution of pathogenicity-associated genes in Rhizoctonia solani AG1-IA by genome duplication and transposon-mediated gene function alterations
BMC Biology, 2023 Background Rhizoctonia solani is a polyphagous fungal pathogen that causes diseases in crops. The fungal strains are classified into anastomosis groups (AGs); however, genomic complexity, diversification into the AGs and the evolution of pathogenicity ...Aleena Francis, Srayan Ghosh, Kriti Tyagi, V. Prakasam, Mamta Rani, Nagendra Pratap Singh, Amrita Pradhan, R. M. Sundaram, C. Priyanka, G. S. Laha, C. Kannan, M. S. Prasad, Debasis Chattopadhyay, Gopaljee Jha +13 moredoaj +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceToward a Molecular Understanding of Plant Hormone Actions
, 2016 Plants rely on a diverse set of small-molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone, auxin, hormones have always been at the frontier Matsuoka, M., Lee, Y., Li, Jiayang, Matsuoka, Makoto, Li, J.Y., Schroeder, J., Lee, Youngsook, Leung, Jeffrey, Zhao, Y.D., Harter, Klaus, Qu, L.J., Li, C.Y., Li, Chuanyou, Offringa, Remko, Qu, Lijia, Martinoia, Enrico, Zhao, Yunde, Chong, K., Offringa, R., Leung, J., Schroeder, Julian, Harter, K., Chong, Kang, Martinoia, E. +23 morecore +1 more sourceDistinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica [PDF]
, 2013 Peer ...Marco Mammella (421707), Julio C. Vega-Arreguin (421715), Horner, N. R., van Rooyen, D., Young, S. K., Guido van den Ackerveken (5650309), Stassen, J.H.M., Javier Dieguez-Uribeondo, Berg, H., Brett M. Tyler (19744), James Christie, Young, Sarah K, Grenville-Briggs, Laura J.,, Grenville-Briggs, L., Arnaud Bottin (41550), Elzbieta Rzeszutek (421711), Andrew J. Phillips (334915), Rooyen, D., van, van den Berg, H., Stan Oome (421709), Chad Nusbaum (253636), van den Berg, Herbert, Sarah K Young, Pieter van West (205267), Christie, James, Berend Snel, Rzeszutek, Elzbieta,, Lars Löbach, Horner, N.R., Díaz-Moreno, S.M., Sarah K. Young (178826), Morris, P., Seidl, M.F., de Bruijn, I., Joshua Z. Levin (177182), Levin, Joshua Z, Sucheta Tripathy, Meijer, Harold J. G., Grenville-Briggs, L. J., Secombes, Chris J, Secombes, Chris J., Grenville-Briggs, Laura J, Carsten Russ, Oome, Stan, Wawra, Stephan, Snel, Berend, Belmonte, Rodrigo, Mammella, M., Marcia Saraiva (421712), Elodie Gaulin (40047), Rodrigo Belmonte, Dieguez-Uribeondo, J., Marco Mammella, Sara M. Díaz-Moreno (421704), Qiandong Zeng (178764), Grenville-Briggs, L.J., Lin Fan (281949), Chad Nusbaum, Dumas, B., Levin, J.Z., Andrew J Phillips, Julio C Vega-Arreguin, Horner, Neil R, Sub Theoretical Biology & Bioinformatics, Haas, B., Dep Biologie, Tyler, Brett M., Meijer, H.J., van den Ackerveken, G., Löbach, Lars, Vega-Arreguin, Julio C, Russ, C., David van Rooyen, et al., Vega-Arreguin, Julio C., Bruijn, I., de, Govers, F., van West, Pieter, van den Ackerveken, A.F.J.M., Díaz-Moreno, S., Nusbaum, Chad, Chris J Secombes, Vega-Arreguin, J. C., Sub Plant-Microbe Interactions, Gaulin, Elodie, Sykes, Sean, Meijer, H.J.G., Irene de Bruijn, Seidl, Michael F., Wawra, S., Stassen, Joost H. M., Nusbaum, C., Paul Morris, Secombes, C.J., Stassen, Joost H M, Stephan Wawra, Laura J. Grenville-Briggs (421705), Bernard Dumas, Saraiva, M., Jiang, R., Phillips, Andrew J, Belmonte, R., Grenville-Briggs, Laura J., de Bruijn, Irene, Stan Oome, Haas, B. J., Harold J. G. Meijer (227595), Saraiva, Marcia, Qiandong Zeng, Rzeszutek, E., Stassen, J. H., Young, Sarah K., Young, S.K., Neil R Horner, Phillips, A. J., Joshua Z Levin, Jiang, R. H., Theoretical Biology and Bioinformatics, Stephan Wawra (421716), Joost H. M. Stassen (221771), David van Rooyen (421710), Bulone, Vincent, Irene de Bruijn (43879), van West, P., Sucheta Tripathy (19740), Secombes, C. J., Michael F. Seidl (221772), Snel, B., Levin, Joshua Z., Michael F Seidl, Gaulin, E., Bottin, A., Joost H M Stassen, Löbach, L., West, P., van, Bernard Dumas (40050), Díaz-Moreno, Sara M., Loebach, Lars, Guido van den Ackerveken, Lars Löbach (421702), Lin Fan, Haas, Brian J, Bulone, Vincent,, Herbert van den Berg, Jiang, Rays H. Y., Sean Sykes (158441), Vincent Bulone, Seidl, Michael F, Tripathy, S., Elzbieta Rzeszutek, Rzeszutek, Elzbieta, van Rooyen, David, Tyler, Brett M, Zeng, Qiandong, Levin, J. Z., Dieguez-Uribeondo, Javier, Morris, Paul, Díaz-Moreno, S. M., Govers, Francine, Tyler, B.M., Vincent Bulone (243055), Jiang, R.H.Y., Meijer, Harold J G, Marcia Saraiva, Neil R. Horner (421706), Arnaud Bottin, Meijer, H. J., Jiang, Rays H Y, Fan, Lin, Young, Sarah, Brett M Tyler, Bulone, V., Laura J Grenville-Briggs, Jiang, R.H.I., Elodie Gaulin, Horner, N., James Christie (421703), Tyler, B. M., Christie, J., Sean Sykes, de Haas, B.J., Sara M Díaz-Moreno, Francine Govers (52155), Francine Govers, Paul Morris (421708), van den Ackerveken, Guido, West, P., Oome, S., Berend Snel (5539), Zeng, Q., Haas, B.J., Chris J. Secombes (421713), Diaz-Moreno, Sara M.,, Vega-Arreguin, J.C., Javier Dieguez-Uribeondo (421717), Haas, Brian J., Fan, L., Carsten Russ (263594), Herbert van den Berg (421714), Sykes, S., Meijer, H., Stassen, J.H., Bottin, Arnaud, Horner, Neil R., Rays H Y Jiang, Ackerveken, G., van den, Russ, Carsten, Pieter van West, Levin, J., Rooyen, D., Plant Microbe Interactions, Harold J G Meijer, Rodrigo Belmonte (421701), Mammella, Marco, Phillips, Andrew J., Phillips, A.J., Brian J. Haas (81121), Rays H. Y. Jiang (421700), Seidl, M. F., Dumas, Bernard, Tripathy, Sucheta, Díaz-Moreno, Sara M, Brian J Haas +222 morecore +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more sourceGenome sequence reveals that Pseudomonas fluorescens F113 possesses a large and diverse array of systems for rhizosphere function and host interaction [PDF]
, 2013 Background: Pseudomonas fluorescens F113 is a plant growth-promoting rhizobacterium (PGPR) isolated from the
sugar-beet rhizosphere. This bacterium has been extensively studied as a model strain for genetic regulation of
secondary metabolite production ...María Sánchez-Contreras, Rivilla Palma, Rafael, Germaine, Kieran, O’Gara, Fergal, Dowling, David N., David Dowling, Sánchez-Contreras, María, Ana Navazo, Rafael Rivilla, Candela, Muriel, Martínez-Granero, Francisco, Barahona, Emma, Martinez-Granero, F., Emma Barahona, Fergal, O´Gara, Francisco Martínez-Granero, Martín, M., Redondo Nieto, Miguel, Morrissey, John P., Sánchez-Contreras, M., Candela Muriel, Barret, M., Moynihan, J., Martín Basanta, Marta, Germaine, K., Barahona, E., Navazo, A., John Morrissey, Jennifer A Moynihan, Sánchez-Contrerasa, María, Dowling, D., Moynihan, Jennifer A., Miguel Redondo-Nieto, Martín, Marta, Navazo, Ana, Morrissey, John, O\u27Gara, Fergal, Moynihan, Jennifer A, Muriel, C., Fergal O’Gara, Barret, Matthieu, Matthieu Barret, Rivilla, Rafael, Moynihan, Jennifer, Morrissey, J., Redondo-Nieto, M., Kieran Germaine, Marta Martín, Redondo-Nieto, Miguel, Rivilla, R., Muriel, Candela, Germaine, Kieran J., Dowling, David, O'Gara, Fergal +53 morecore +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more source
