Results 11 to 20 of about 25,444 (143)

A novel component of the mitochondrial genome segregation machinery in trypanosomes

Microbial Cell, 2016
We recently described a new component (TAC102) of the mitochondrial genome segregation machinery (mtGSM) in the protozoan parasite Trypanosoma brucei. T.
Anneliese Hoffmann, Martin Jakob, Torsten Ochsenreiter   +2 more
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Homologous Recombination in Protozoan Parasites and Recombinase Inhibitors

Frontiers in Microbiology, 2017
Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that utilizes a homologous template to fully repair the damaged DNA. HR is critical to maintain genome stability and to ensure genetic diversity during meiosis. A specialized
Andrew A. Kelso, Andrew A. Kelso, Sarah M. Waldvogel, Adam J. Luthman, Michael G. Sehorn, Michael G. Sehorn, Michael G. Sehorn, Michael G. Sehorn   +7 more
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Comparative transcriptome combined with morphophysiological analyses revealed the molecular mechanism underlying Tetrahymena thermophila predation-induced antiphage defense in Aeromonas hydrophila

Virulence, 2022
Protozoan predation has been demonstrated to be a strong driving force for bacterial defence strategies in the environment. Our previous study demonstrated that Aeromonas hydrophila NJ-35, which evolved small-colony variants (SCVs), displayed various ...
Yuhao Dong, Jin Liu, Meng Nie, Dan Zhao, Hao Huang, Jinzhu Geng, Xihe Wan, Chengping Lu, Yongjie Liu   +8 more
doaj   +1 more source

Pseudocohnilembus persalinus genome database - the first genome database of facultative scuticociliatosis pathogens

BMC Genomics, 2018
Background Pseudocohnilembus persalinus, a unicellular ciliated protozoan, is one of commonest facultative pathogens. We sequenced the macronuclear genome of P. persalinus in 2015, which provided new insights into its pathogenicity.
Wei Wei, Kai Chen, Wei Miao, Wentao Yang, Jie Xiong   +4 more
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Functional annotation and comparative genomics analysis of Balamuthia mandrillaris reveals potential virulence-related genes

Scientific Reports, 2023
Balamuthia mandrillaris is a pathogenic protozoan that causes a rare but almost always fatal infection of the central nervous system and, in some cases, cutaneous lesions. Currently, the genomic data for this free-living amoeba include the description of
Alejandro Otero-Ruiz, Libia Zulema Rodriguez-Anaya, Fernando Lares-Villa, Luis Fernando Lozano Aguirre Beltrán, Luis Fernando Lares-Jiménez, Jose Reyes Gonzalez-Galaviz, Abraham Cruz-Mendívil   +6 more
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Taming Parasites by Tailoring Them

Frontiers in Cellular and Infection Microbiology, 2017
The next-generation gene editing based on CRISPR (clustered regularly interspaced short palindromic repeats) has been successfully implemented in a wide range of organisms including some protozoan parasites.
Bingjian Ren, Nishith Gupta
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A rapid and simple method of detection of Blepharisma japonicum using PCR and immobilisation on FTA paper

BMC Ecology, 2003
Background The rapid expansion in the availability of genome and DNA sequence information has opened up new possibilities for the development of methods for detecting free-living protozoa in environmental samples.
Hughes Jacqueline M, Hide Geoff, McNuff Robert   +2 more
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Identification of scaffold/Matrix Attachment (S/MAR) like DNA element from the gastrointestinal protozoan parasite Giardia lamblia

BMC Genomics, 2010
Background Chromatin in the nucleus of all eukaryotes is organized into a system of loops and domains. These loops remain fastened at their bases to the fundamental framework of the nucleus, the matrix or the scaffold.
Gautam Pennathur, Banerjee Santanu, Gupta Ravi, Lakshmanan Jagannathan, Padmaja Sushma S, Banerjee Sulagna   +5 more
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Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major

Journal of Nucleic Acids, 2010
A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair ...
Danielle Gomes Passos-Silva, Matheus Andrade Rajão, Pedro Henrique Nascimento de Aguiar, João Pedro Vieira-da-Rocha, Carlos Renato Machado, Carolina Furtado   +5 more
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Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections

Genome Medicine, 2019
A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method for drug target
Annie N. Cowell, Elizabeth A. Winzeler
doaj   +1 more source