Results 111 to 120 of about 669,373 (262)

The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing

Advanced Materials, EarlyView.
With the growing demand for cell‐based therapies, efficient cellular engineering is crucial. This review calls for greater recognition of mechanobiology principles applied through advanced biomaterial designs, mechanical confinement, and highlights recent advances using micro/nanotechnologies to enhance cell manufacturing.
Huan Ting Ong, M Sriram, Hepi Hari Susapto, Yixuan Li, Yuan Jiang, Nicolas H. Voelcker, Jennifer L. Young, Andrew W. Holle, Roey Elnathan   +8 more
wiley   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Biomolecular Condensates as Emerging Biomaterials: Functional Mechanisms and Advances in Computational and Experimental Approaches

Advanced Materials, EarlyView.
Integration of computational and experimental approaches for deciphering the underlying mechanism of biomolecular condensates and potential biomaterials design (Created in Biorender. Raza, Z. (2025) https://BioRender.com/irgmeqi). Abstract Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be ...
Qiang Zhu, Zahra Raza, Dzung Do‐Ha, Emma De Costa, Pavlina Sasheva, Luke McAlary, Hadi Mahmodi, Warwick P. Bowen, Lezanne Ooi, Irina Kabakova, Haibo Yu   +10 more
wiley   +1 more source

A Programmable Nanovaccine Platform Based on M13 Bacteriophage for Personalized Cancer Vaccine and Therapy

Advanced Materials, EarlyView.
A reprogrammed (RP) phage‐based nanovaccine platform has been developed that allows single‐step assembly with precise control over adjuvanticity, antigen density, and nanoparticle size. By enhancing TLR9 activation and neoantigen display, this platform enables a potent personalized vaccine targeting tumor‐specific neoantigens. When combined with immune
Shengnan Huang, Yanpu He, Allison Madow, Huaiyao Peng, Mirielle Griffin, Jifa Qi, Mantao Huang, Heather Amoroso, Riley Abrashoff, Nimrod Heldman, Angela M. Belcher   +10 more
wiley   +1 more source

Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic

Advanced Sensor Research, EarlyView.
This review discusses nanomaterial‐based optical biosensors developed for or adapted to the detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It concludes by providing a perspective on how lessons learned during the coronavirus disease of 2019 (COVID‐19) pandemic may be applied for future research on nanomaterial‐based ...
Flavie Martin, Scott G. Harroun, Michel Meunier   +2 more
wiley   +1 more source

Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection [PDF]

, 1984
The replication of murine cytomegalovirus strain Smith in murine embryonic fibroblasts was investigated at immediate early, early, and late times after infection.
Ebeling-Keil, Angelika, Keil, Günther M., Koszinowski, Ulrich H.   +2 more
core   +1 more source

From Lab to Market: Paper‐Based CRISPR Diagnostics and Commercialization Pathways

Advanced Sensor Research, EarlyView.
Paper‐based CRISPR diagnostics represents one of the most widely commercialized CRISPR assay technologies, yet challenges remain for broader point‐of‐care use. Abstract The global health landscape is continually challenged by infectious diseases that can swiftly escalate into pandemics, underscoring the need for rapid, accurate, and cost‐effective ...
Selen Dalgan, Qingshan Wei
wiley   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source