Results 81 to 90 of about 516,921 (266)

Virus hepatitisa G - novi hepatotropni virus [PDF]

Vojnosanitetski Pregled, 2002
Kuljić-Kapulica Nada
doaj   +1 more source

The accessibility of the HSV genome during productive infection can vary in different cell types and affect the outcome of infection

mBio
During productive herpes simplex virus type 1 (HSV-1) infection, the viral genome encounters a number of cellular and viral proteins, such as ICP4, which engage in processes that either attenuate or activate transcription.
Jenna M. Nosek, Sarah E. Dremel, Neal A. DeLuca   +2 more
doaj   +1 more source

vir2vec: A Viral Genome-Wide Viral Embedding

Abstract Genomic language models (gLMs) have recently emerged as powerful numerical surrogates for DNA, but existing architectures are largely focused on human DNA or trained on limited viral references, and no dedicated benchmark currently exists for viral genome understanding.
Simone Rancati, Pablo Arozarena Donelli, Giovanna Nicora, Laura Bergomi, Tommaso Mario Buonocore, Micheal Aaron Sy, Sakshi Pandey, Mattia Prosperi, Marco Salemi, Riccardo Bellazzi, Christina Boucher, Enea Parimbelli, Simone Marini   +12 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism

iScience
Summary: Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system.
Binbin Yi, Yuri L. Tanaka, Daphne Cornish, Hidetaka Kosako, Erika P. Butlertanaka, Prabuddha Sengupta, Jennifer Lippincott-Schwartz, Judd F. Hultquist, Akatsuki Saito, Shige H. Yoshimura   +9 more
doaj   +1 more source

Vgas: A Viral Genome Annotation System

Frontiers in Microbiology, 2019
The in-depth study of viral genomes is of great help in many aspects, especially in the treatment of human diseases caused by viral infections. With the rapid accumulation of viral sequencing data, improved, or alternative gene-finding systems have ...
Kai-Yue Zhang, Yi-Zhou Gao, Meng-Ze Du, Shuo Liu, Chuan Dong, Feng-Biao Guo   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source