Results 81 to 90 of about 2,630,320 (343)

Improved reference genome of the arboviral vector Aedes albopictus [PDF]

, 2020
Background: The Asian tiger mosquito Aedes albopictus is globally expanding and has become the main vector for human arboviruses in Europe. With limited antiviral drugs and vaccines available, vector control is the primary approach to prevent mosquito ...
Akbari, Omar,, Antoshechkin, Igor, Biedler, James,, Bonizzoni, Mariangela, Caccone, Adalgisa, Cosme, Luciano,, Crawford, Jacob,, Failloux, Anna-Bella, Gamez, Stephanie, Ghurye, Jay, Halbach, Rebecca, Jenrette, Jeremy, Johnston, J. Spencer, Karagodin, Dmitry,, Koren, Sergey, Krsticevic, Flavia, Marconcini, Michele, Masri, Reem,, Masterson, Patrick, Miesen, Pascal, Palatini, Umberto, Papathanos, Philippos,, Phillippy, Adam,, Pischedda, Elisa, Powell, Jeffrey, Rhie, Arang, Sharakhova, Maria,, Sharma, Atashi, Thibaud-Nissen, Francoise, Tu, Zhijian, van Rij, Ronald,   +30 more
core   +5 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation

mBio, 2022
Influenza viral particles are assembled at the plasma membrane concomitantly with Rab11a-mediated endocytic transport of viral ribonucleoprotein complexes (vRNPs).
Takahiro Kuroki, Tomohisa Hatta, Tohru Natsume, Nobuaki Sakai, Akira Yagi, Kohsuke Kato, Kyosuke Nagata, Atsushi Kawaguchi   +7 more
doaj   +1 more source

Complete Genome Viral Phylogenies Suggests the Concerted Evolution of Regulatory Cores and Accessory Satellites

PLoS ONE, 2008
We consider the concerted evolution of viral genomes in four families of DNA viruses. Given the high rate of horizontal gene transfer among viruses and their hosts, it is an open question as to how representative particular genes are of the evolutionary ...
P. Zanotto, D. Krakauer
semanticscholar   +1 more source

COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing

Clinical Infectious Diseases, 2020
Background Waning immunity occurs in patients who have recovered from COVID-19. However, it remains unclear whether true re-infection occurs. Methods Whole genome sequencing was performed directly on respiratory specimens collected during two episodes of
K. To, I. Hung, J. D. Ip, A. W. Chu, W. Chan, A. Tam, C. Fong, Shuofeng Yuan, H. Tsoi, A. C. Ng, Larry Lee, P. Wan, E. Tso, W. To, D. Tsang, Kwok-Hung Chan, Jian-Dong Huang, K. Kok, V. Cheng, K. Yuen   +19 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Cell Cycle Timing of Human Papillomavirus DNA Replication. [PDF]

PLoS ONE, 2015
Viruses manipulate the cell cycle of the host cell to optimize conditions for more efficient viral genome replication. One strategy utilized by DNA viruses is to replicate their genomes non-concurrently with the host genome; in this case, the viral ...
Tormi Reinson, Liisi Henno, Mart Toots, Mart Ustav, Mart Ustav   +4 more
doaj   +1 more source

Library Preparation Based on Transposase Assisted RNA/DNA Hybrid Co-Tagmentation for Next-Generation Sequencing of Human Noroviruses

Viruses, 2021
Human noroviruses (HuNoVs) are one of the leading causes of foodborne illnesses globally. The viral genome is the most essential information for viral source tracing and viral transmission pattern monitoring. However, whole genome sequencing of HuNoVs is
Zilei Zhang, Danlei Liu, Dapeng Wang, Qingping Wu   +3 more
doaj   +1 more source

Multipartite viruses: A decentralized mode of functioning. [O.24] [PDF]

, 2015
Multipartite viruses are characterized by a genome composed of two or more nucleic acid segments, each encapsidated indivually. A classical view in virology assumes that the viral replication cycle occurs within individual cells, where the whole viral ...
Blanc, Stéphane, Gutiérrez, Serafin, Michalakis, Yannis, Sicard, Anne, Vernerey, Marie-Stéphanie   +4 more
core  

Improved vectors and genome-wide libraries for CRISPR screening

Nature Methods, 2014
Genome-wide, targeted loss-of-function pooled screens using the CRISPR (clustered regularly interspaced short palindrome repeats)–associated nuclease Cas9 in human and mouse cells provide an alternative screening system to RNA interference (RNAi) and ...
Neville E. Sanjana, Ophir Shalem, Feng Zhang   +2 more
semanticscholar   +1 more source