Results 61 to 70 of about 1,842,476 (313)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection

mSystems, 2022
Human cells identify invading pathogens and activate immune signaling pathways through a wide array of pattern recognition receptors, including DNA sensors.
Timothy R. Howard, Krystal K. Lum, Michelle A. Kennedy, Ileana M. Cristea   +3 more
doaj   +1 more source

Novel bacteriophages containing a genome of another bacteriophage within their genomes [PDF]

, 2012
The work was funded by the Scottish Government’s Rural and Environment Science and Analytical Services (RESAS) DivisionA novel bacteriophage infecting Staphylococus pasteuri was isolated during a screen for phages in Antarctic soils.
Makarova Kira S., Koonin, Eugene V, Peter J Cock, Torrance Lesley, Kira S Makarova, Swanson, Maud M, Lesley Torrance, Torrance, Lesley, Reavy Brian, Hopkins, David W, Reavy, Brian, Hopkins, David W., Michael Taliansky, Cock, Peter J, Hopkins David W., Makarova, Kira S, Maud M Swanson, Swanson, Maud M., Makarova, Kira S., Koonin, Eugene V., Koonin Eugene V., Swanson Maud M., Taliansky, Michael, Cock Peter J., David W Hopkins, Taliansky Michael, Cock, Peter J., Brian Reavy, Eugene V Koonin   +28 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

High-throughput screening of human genetic variants by pooled prime editing

Cell Genomics
Summary: Multiplexed assays of variant effect (MAVEs) enable scalable functional assessment of human genetic variants. However, established MAVEs are limited by exogenous expression of variants or constraints of genome editing.
Michael Herger, Christina M. Kajba, Megan Buckley, Ana Cunha, Molly Strom, Gregory M. Findlay   +5 more
doaj   +1 more source

Viral genome integration of canine papillomavirus 16

Papillomavirus Research, 2019
Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer.
Jennifer Luff, Michelle Mader, Peter Rowland, Monica Britton, Joseph Fass, Hang Yuan   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Functional RNA Elements in the Dengue Virus Genome

Viruses, 2011
Dengue virus (DENV) genome amplification is a process that involves the viral RNA, cellular and viral proteins, and a complex architecture of cellular membranes.
Andrea V. Gamarnik, Claudia V. Filomatori, Leopoldo G. Gebhard   +2 more
doaj   +1 more source

Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain

mBio, 2020
The genomes of DNA tumor viruses regain nuclear localization after nuclear envelope breakdown during mitosis through the action of a viral protein with a chromatin-tethering domain (CTD).
Shelby M. Lyon, Kristen D. Yetming, Christina Paulus, Michael Nevels, Robert F. Kalejta   +4 more
doaj   +1 more source

Evolutionary trajectory of white spot syndrome virus (WSSV) genome shrinkage during spread in Asia [PDF]

, 2010
Background - White spot syndrome virus (WSSV) is the sole member of the novel Nimaviridae family, and the source of major economic problems in shrimp aquaculture.
Bui Thi Minh Dieu, Zwart, Mark P., Lia Hemerik, Hemerik, L., Mark P. Zwart, Just M. Vlak, Mark P Zwart, Dieu, Bui Thi Minh, Vlak, J.M., Hemerik, Lia, Just M Vlak, Zwart, M.P., Vlak, Just M.   +12 more
core   +2 more sources