Results 71 to 80 of about 1,842,476 (313)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Virseqimprover: an integrated pipeline for viral contig error correction, extension, and annotation [PDF]

PeerJ
Despite the recent surge of viral metagenomic studies, it remains a significant challenge to recover complete virus genomes from metagenomic data. The majority of viral contigs generated from de novo assembly programs are highly fragmented, presenting ...
Haoqiu Song, Saima Sultana Tithi, Connor Brown, Frank O. Aylward, Roderick Jensen, Liqing Zhang   +5 more
doaj   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dengue Virus Genome Uncoating Requires Ubiquitination

mBio, 2016
The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Laura A. Byk, Néstor G. Iglesias, Federico A. De Maio, Leopoldo G. Gebhard, Mario Rossi, Andrea V. Gamarnik   +5 more
doaj   +1 more source

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Nature Communications, 2023
Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to CRISPR-based gene therapy.
Markus Grosch, Laura Schraft, Adrian Chan, Leonie Küchenhoff, Kleopatra Rapti, Anne-Maud Ferreira, Julia Kornienko, Shengdi Li, Michael H. Radke, Chiara Krämer, Sandra Clauder-Münster, Emerald Perlas, Johannes Backs, Michael Gotthardt, Christoph Dieterich, Maarten M. G. van den Hoogenhof, Dirk Grimm, Lars M. Steinmetz   +17 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors

Cell Reports, 2018
Summary: Following cessation of continuous Ebola virus (EBOV) transmission within Western Africa, sporadic EBOV disease (EVD) cases continued to re-emerge beyond the viral incubation period.
Shannon L.M. Whitmer, Jason T. Ladner, Michael R. Wiley, Ketan Patel, Gytis Dudas, Andrew Rambaut, Foday Sahr, Karla Prieto, Samuel S. Shepard, Ellie Carmody, Barbara Knust, Dhamari Naidoo, Gibrilla Deen, Pierre Formenty, Stuart T. Nichol, Gustavo Palacios, Ute Ströher   +16 more
doaj   +1 more source

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. [PDF]

, 2012
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the ...
Lisnić, V. (V) J. (J), Marcinowski, Lisa, Tanguy, M. (M), Ruzsics, Zsolt, Tanguy Mélanie, Ralf Zimmer, Jonjic, S. (S), Erhard, F. (F), Krmpotic Astrid, Marina Babic (184917), Corinna Benkartek, Bernd Rädle (138968), Zsolt Ruzsics, Babic, Marina, Ruzsics, Z. (Zsolt), Jonjic Stipan, Trgovcich, Joanne, Erhard, Florian, Chane-woon-ming, B. (Béatrice), Tanguy, Mélanie, Chane-Woon-Ming Béatrice, Koszinowski, U. (Ulrich H), Marcinowski Lisa, Marina Babic, Ulrich H Koszinowski, Koszinowski Ulrich H., Joanne Trgovcich (184921), Astrid Krmpotic (184892), Stipan Jonjic (139671), Stipan Jonjic, Babic Marina, Vanda J. Lisnić (184897), Krmpotic, A. (A), Sébastien Pfeffer, Benkartek Corinna, Zsolt Ruzsics (75383), Béatrice Chane-Woon-Ming (184904), Zimmer Ralf, Lisa Marcinowski (138962), Marcinowski, L. (L), Marcinowski, L. (Lisa), Krmpotic, Astrid, Dölken, Lars, Béatrice Chane-Woon-Ming, Joanne Trgovcich, Rädle Bernd, Trgovcich, J. (Joanne), Rädle, B. (Bernd), Lars Dölken, Astrid Krmpotic, Florian Erhard (184910), Lars Dölken (138985), Babic, M. (M), Jonjic, S. (Stipan), Ulrich H. Koszinowski (152143), Lisnić, Vanda J., Lisnić, V. (Vanda J), Trgovcich Joanne, Benkartek, Corinna, Zimmer, Ralf, Erhard Florian, Dölken Lars, Ruzsics, Z. (Z), Ralf Zimmer (21157), Rädle, B. (B), Dölken, L. (L), Vanda J Lisnić, Tuddenham, L. (Lee), Trgovcich, J. (J), Lisnić Vanda J., Lee Tuddenham (141455), Pfeffer, S. (Sebastien), Rädle, Bernd, Corinna Benkartek (184913), Lisa Marcinowski, Zimmer, R. (Ralf), Tuddenham Lee, Benkartek, C. (C), Lee Tuddenham, Erhard, F. (Florian), Pfeffer Sébastien, Babic, M. (Marina), Tuddenham, Lee, Mélanie Tanguy (4691986), Mélanie Tanguy, Florian Erhard, Koszinowski, U. (U) H. (H), Ruzsics Zsolt, Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Tanguy, M. (Mélanie), Dölken, L. (Lars), Zimmer, R. (R), Chane-Woon-Ming, Béatrice, Bernd Rädle, Sébastien Pfeffer (8264), Pfeffer, Sébastien, Benkartek, C. (Corinna), Jonjic, Stipan   +98 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Chemistry and Bioinformatics Considerations in Using Next-Generation Sequencing Technologies to Inferring HIV Proviral DNA Genome-Intactness

Viruses, 2021
HIV persists via integration of the viral DNA into the human genome. The HIV DNA pool within an infected individual is a complex population that comprises both intact and defective viral genomes, each with a distinct integration site, in addition to a ...
Guinevere Q. Lee
doaj   +1 more source