Results 101 to 110 of about 3,091,688 (344)

A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle

Frontiers in Genetics, 2019
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions and genetic variants associated with phenotypes. However, only limited mutual confirmation from different studies is available.
Jicai Jiang, Li Ma, Dzianis Prakapenka, P. Vanraden, J. Cole, Y. Da   +5 more
semanticscholar   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

A Genome-Wide Association Study for Calving Interval in Holstein Dairy Cows Using Weighted Single-Step Genomic BLUP Approach

Animals, 2020
The aim of the present study was to identify genomic region(s) associated with the length of the calving interval in primiparous (n = 6866) and multiparous (n = 5071) Holstein cows.
Hadi Atashi, Mazdak Salavati, Jenne De Koster, Mark A. Crowe, Geert Opsomer, Miel Hostens, The GplusE Consortium   +6 more
doaj   +1 more source

High-dimensional genome-wide association study and misspecified mixed model analysis

, 2014
We study behavior of the restricted maximum likelihood (REML) estimator under a misspecified linear mixed model (LMM) that has received much attention in recent gnome-wide association studies.
Jiang, Jiming, Li, Cong, Paul, Debashis, Yang, Can, Zhao, Hongyu   +4 more
core  

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Privacy-preserving federated genome-wide association studies via dynamic sampling [PDF]

, 2023
Xinyue Wang, Leonard Dervishi, Wentao Li, Erman Ayday, Xiaoqian Jiang, Jaideep Vaidya   +5 more
openalex   +1 more source

Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders [PDF]

, 2017
Twin studies indicate that latent genetic factors overlap across comorbid psychiatric disorders. In this study, we used a novel approach to elucidate shared genetic factors across psychiatric outcomes by clustering single nucleotide polymorphisms based ...
Adkins, Amy E., Aliev, Fazil, Bucholz, Kathleen K., Cho, Seung Bin, Clark, Shaunna L., Dick, Danielle M., Edenberg, Howard J., Porjesz, Bernice   +7 more
core   +1 more source

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

bioRxiv, 2019
Rationale Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium.
R. Allen, B. Guillen-Guio, J. Oldham, Shwu-Fan Ma, A. Dressen, Megan L. Paynton, L. M. Kraven, M. Obeidat, Xuan Li, M. Ng, R. Braybrooke, M. Molina-Molina, B. Hobbs, R. Putman, P. Sakornsakolpat, H. Booth, W. Fahy, S. Hart, M. Hill, N. Hirani, R. Hubbard, R. McAnulty, A. Millar, V. Navaratnam, E. Oballa, H. Parfrey, G. Saini, M. Whyte, Yingze Zhang, N. Kaminski, A. Adegunsoye, M. Strek, M. Neighbors, X. R. Sheng, G. Gudmundsson, V. Gudnason, H. Hatabu, D. Lederer, A. Manichaikul, J. Newell, G. O'Connor, V. Ortega, Hanfei Xu, T. Fingerlin, Y. Bossé, K. Hao, P. Joubert, D. Nickle, D. Sin, W. Timens, D. Furniss, A. Morris, K. Zondervan, I. Hall, I. Sayers, M. Tobin, T. Maher, M. Cho, G. Hunninghake, D. Schwartz, B. Yaspan, P. Molyneaux, C. Flores, I. Noth, R. Jenkins, L. Wain   +65 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Characterization of Insect Resistance Loci in the USDA Soybean Germplasm Collection Using Genome-Wide Association Studies

Frontiers in Plant Science, 2017
Management of insects that cause economic damage to yields of soybean mainly rely on insecticide applications. Sources of resistance in soybean plant introductions (PIs) to different insect pests have been reported, and some of these sources, like for ...
Hao-Xun Chang, Glen L. Hartman
doaj   +1 more source