Results 111 to 120 of about 3,155,630 (345)
Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski +14 morewiley +1 more sourceGenome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis
bioRxiv, 2019 Rationale Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium.R. Allen, B. Guillen-Guio, J. Oldham, Shwu-Fan Ma, A. Dressen, Megan L. Paynton, L. M. Kraven, M. Obeidat, Xuan Li, M. Ng, R. Braybrooke, M. Molina-Molina, B. Hobbs, R. Putman, P. Sakornsakolpat, H. Booth, W. Fahy, S. Hart, M. Hill, N. Hirani, R. Hubbard, R. McAnulty, A. Millar, V. Navaratnam, E. Oballa, H. Parfrey, G. Saini, M. Whyte, Yingze Zhang, N. Kaminski, A. Adegunsoye, M. Strek, M. Neighbors, X. R. Sheng, G. Gudmundsson, V. Gudnason, H. Hatabu, D. Lederer, A. Manichaikul, J. Newell, G. O'Connor, V. Ortega, Hanfei Xu, T. Fingerlin, Y. Bossé, K. Hao, P. Joubert, D. Nickle, D. Sin, W. Timens, D. Furniss, A. Morris, K. Zondervan, I. Hall, I. Sayers, M. Tobin, T. Maher, M. Cho, G. Hunninghake, D. Schwartz, B. Yaspan, P. Molyneaux, C. Flores, I. Noth, R. Jenkins, L. Wain +65 moresemanticscholar +1 more sourceInvestigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov +10 morewiley +1 more sourceTIMP4 as a Potential Complementary Biomarker and Therapeutic Target in Membranous Nephropathy: A Multi-Omics Investigation with Clinical Validation
Journal of Inflammation ResearchQingsong Chen, Gang Wang, Ruo Zhao, Qiyuan Hu, Jiayun Li, Yuting Wang, Jingyang Ran, Qi Huang, Guiquan Yu, Yanjia Luo, Xiaohui Liao Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...Chen Q, Wang G, Zhao R, Hu Q, Li J, Wang Y, Ran J, Huang Q, Yu G, Luo Y, Liao X +10 moredoaj Genome-wide Association Study of Peripheral Artery Disease in the Million Veteran Program
Nature Medicine, 2019 Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality; however, the extent to which genetic factors increase risk for PAD is largely unknown.D. Klarin, J. Lynch, Krishna G. Aragam, M. Chaffin, T. Assimes, Jie Huang, K. Lee, Q. Shao, J. Huffman, P. Natarajan, S. Arya, Aeron M. Small, Yan V. Sun, M. Vujković, M. Freiberg, Lu Wang, Jinbo Chen, D. Saleheen, Jennifer S. Lee, Donald R. Miller, P. Reaven, Patrick R. Alba, Olga V. Patterson, S. Duvall, W. Boden, J. Beckman, J. Gaziano, J. Concato, D. Rader, Kelly Cho, Kyong‐Mi Chang, P. Wilson, C. O’Donnell, S. Kathiresan, P. Tsao, S. Damrauer +35 moresemanticscholar +1 more sourceIntegrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar +13 morewiley +1 more sourceGenetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
eLife, 2018 Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 15,453 UL cases and 392,628 controls was performed, followed by replication of the genomic risk in six cohorts.Niko Välimäki, Heli Kuisma, Annukka Pasanen, Oskari Heikinheimo, Jari Sjöberg, Ralf Bützow, Nanna Sarvilinna, Hanna-Riikka Heinonen, Jaana Tolvanen, Simona Bramante, Tomas Tanskanen, Juha Auvinen, Outi Uimari, Amjad Alkodsi, Rainer Lehtonen, Eevi Kaasinen, Kimmo Palin, Lauri A Aaltonen +17 moredoaj +1 more sourceGenome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
Nature Communications, 2019 Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study P. Lyons, J. Peters, F. Alberici, J. Liley, R. Coulson, W. Astle, C. Baldini, F. Bonatti, M. Cid, H. Elding, G. Emmi, J. Epplen, L. Guillevin, D. Jayne, T. Jiang, I. Gunnarsson, P. Lamprecht, S. Leslie, M. Little, D. Martorana, F. Moosig, T. Neumann, S. Ohlsson, S. Quickert, G. Ramirez, B. Rewerska, G. Schett, R. Sinico, W. Szczeklik, V. Tesar, Damjan Vukcevic, B. Terrier, R. Watts, A. Vaglio, J. Holle, C. Wallace, Kenneth G. C. Smith +36 moresemanticscholar +1 more source
