Results 141 to 150 of about 3,155,630 (345)
Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann +15 morewiley +1 more sourceA genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis. [PDF]
, 2019 BackgroundHuman milk oligosaccharides (OS) play a key role in brain and gut microbiota development of the neonate, but the underlying biosynthetic steps of OS in the mammary gland are still largely unknown.Barile, Daniela, Buitenhuis, Bart, Larsen, Lotte B, Poulsen, Nina A, Robinson, Randall C +4 morecore +1 more sourceClass IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more sourceGenome-wide association study identifies novel breast cancer susceptibility loci
Nature, 2007 Don M. Conroy, M. Shah, Hannah Munday, C. Jordan, B. Perkins, Judy West, Karen Redman, K. Driver, M. Aghmesheh, D. Amor, Lesley Andrews, Y. Antill, Jane Armes, Shane Armitage, Leanne Arnold, Rosemary L. Balleine, Glenn Begley, J. Beilby, Ian Bennett, Barbara Bennett, Geoffrey Berry, Anneke Blackburn, Meagan Brennan, Melissa Brown, Michael Buckley, J. Burke, P. Butow, Keith Byron, David F. Callen, Ian Campbell, G. Chenevix-Trench, Christine L. Clarke, Alison Colley, Dick Cotton, Jisheng Cui, Bronwyn Culling, Margaret Cummings, Sarah-Jane Dawson, Joanne Dixon, Alexander Dobrovic, Tracy Dudding, Ted Edkins, M. Eisenbruch, G. Farshid, Susan Fawcett, Michael Field, F. Firgaira, Jean Fleming, John F Forbes, M. Friedlander, Clara Gaff, Mac Gardner, M. Gattas, Peter George, G. Giles, G. Gill, Jack Goldblatt, Sian Greening, S. Grist, E. Haan, Marion Harris, Stewart Hart, N. Hayward, J. Hopper, Evelyn Humphrey, M. Jenkins, Alison Jones, R. Kefford, Judy Kirk, James Kollias, Sergey Kovalenko, Sunil R. Lakhani, Jennifer Leary, Jacqueline Lim, Geoff Lindeman, Lara Lipton, Lizz Lobb, Mariette Maclurcan, Graham J. Mann, Deb Marsh, M. Mccredie, Michael McKay, Sue-Anne McLachlan, B. Meiser, R. Milne, Gillian Mitchell, Beth Newman, Imelda O’Loughlin, Lester Peters, K. Phillips, Melanie Price, Jeanne Reeve, Tony Reeve, Gina Rinehart, Bridget Robinson, Elizabeth Salisbury, J. Sambrook, Christobel Saunders, C. Scott, Elizabeth Scott, Rodney J. Scott, Andrew N Shelling, M. Southey, A. Spurdle, Graeme Suthers, Donna Taylor, Christopher Tennant, Heather Thorne, S. Townshend, Kathy Tucker, Janet Tyler, D. Venter, J. Visvader, I. Walpole, Robin Ward, P. Waring, Bev Warner, Graham Warren, Elizabeth Watson, Rachael Williams, Judy Wilson, Ingrid Winship, Adele Green, D. Gertig, P. Webb +124 moresemanticscholar +1 more sourceIn vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow +10 morewiley +1 more sourceGene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Nature Genetics, 2018 James J. Lee, Robbee Wedow, A. Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, J. Sidorenko, R. Karlsson Linnér, M. Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, P. Timshel, R. Walters, E. Willoughby, L. Yengo, Michelle Babak Adam Robert K. Katarzyna Sarah L. Pierre Dav Agee Alipanahi Auton Bell Bryc Elson Fontanillas H, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, D. Hinds, J. McCreight, K. Huber, N. Litterman, M. Mcintyre, Joanna L. Mountain, E. Noblin, C. Northover, S. Pitts, J. Sathirapongsasuti, O. V. Sazonova, J. Shelton, S. Shringarpure, C. Tian, V. Vacic, C. H. Wilson, Aysu Jonathan P. Mark Alan James J. Tune H. Cornelius A Okbay Beauchamp Fontana Lee Pers Rietveld Turley C, A. Okbay, J. Beauchamp, James J. Lee, T. Pers, C. A. Rietveld, P. Turley, Guo-Bo Chen, V. Emilsson, S. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, P. Timshel, R. Vlaming, A. Abdellaoui, T. Ahluwalia, J. Bacelis, C. Baumbach, G. Bjornsdottir, J. Brandsma, M. P. Concas, J. Derringer, N. Furlotte, T. Galesloot, G. Girotto, Richa Gupta, Leanne M. Hall, Sarah E. Harris, E. Hofer, M. Horikoshi, J. Huffman, Kadri Kaasik, I. Kalafati, R. Karlsson, Augustine Kong, J. Lahti, S. J. van der Lee, C. D. Leeuw, P. Lind, Karl-Oskar Lindgren, Tian Liu, M. Mangino, J. Marten, E. Mihailov, Michael B. Miller, Peter J. van der Most, C. Oldmeadow, A. Payton, N. Pervjakova, W. Peyrot, Yong Qian, Olli T Raitakari, R. Rueedi, E. Salvi, Börge Schmidt, Katharina E. Schraut, Jianxin Shi, A. Smith, R. Poot, Beate St Pourcain, A. Teumer, G. Thorleifsson, N. Verweij, D. Vuckovic, J. Wellmann, H. Westra, Jingyun Yang, Wei Zhao, Zhihong Zhu, B. Alizadeh, N. Amin, A. Bakshi, S. Baumeister, G. Biino, K. Bønnelykke, P. Boyle, H. Campbell, Francesco P. Cappuccio, G. Davies, J. De Neve, P. Deloukas, I. Demuth, Jun Ding, P. Eibich, L. Eisele, N. Eklund, David M. Evans, J. Faul, M. Feitosa, A. Forstner, I. Gandin, Bjarni Gunnarsson, B. Halldórsson, T. Harris, Andrew C. Heath, L. Hocking, Elizabeth G. Holliday, G. Homuth, Michael A. Horan, J. Hottenga, P. D. De Jager, Peter K. Joshi, A. Jugessur, M. Kaakinen, M. Kähönen, S. Kanoni, Liisa Keltigangas-Järvinen, L. Kiemeney, I. Kolčić, S. Koskinen, A. Kraja, Martin Kroh, Z. Kutalik, A. Latvala, L. Launer, Maël P. Lebreton, D. Levinson, P. Lichtenstein, P. Lichtner, D. Liewald, LifeLines Cohort Study, Anu Loukola, P. Madden, R. Mägi, T. Mäki-Opas, R. Marioni, P. Marques-Vidal, Gerardus A. Meddens, George Mcmahon, Christa Meisinger, T. Meitinger, Y. Milaneschi, L. Milani, G. Montgomery, Ronny Myhre, Christopher P. Nelson, D. Nyholt, William E. R. Ollier, A. Palotie, L. Paternoster, N. Pedersen, Katja E. Petrovic, D. Porteous, K. Räikkönen, Susan M. Ring, A. Robino, Olga Rostapshova, I. Rudan, Aldo Rustichini, V. Salomaa, A. Sanders, Antti-Pekka Sarin, H. Schmidt, Rodney J Scott, Blair H. Smith, Jennifer A Smith, J. Staessen, Elisabeth Steinhagen-Thiessen, K. Strauch, A. Terracciano, Martin D. Tobin, Sheila Ulivi, S. Vaccargiu, L. Quaye, F. V. van Rooij, Cristina Venturini, Anna A. E. Vinkhuyzen, U. Völker, H. Völzke, J. Vonk, D. Vozzi, Johannes Waage, E. Ware, G. Willemsen, J. Attia, David A. Bennett, Klaus Berger, L. Bertram, H. Bisgaard, D. Boomsma, I. Borecki, Ute Bültmann, C. Chabris, F. Cucca, D. Cusi, I. Deary, G. Dedoussis, Cornelia M. van Duijn, J. Eriksson, Barbara Franke, L. Franke, Paolo Gasparini, P. Gejman, C. Gieger, Hans‐Jörgen Grabe, J. Gratten, Patrick J. F. Groenen, V. Gudnason, P. van der Harst, Caroline Hayward, Wolfgang Hoffmann, Elina Hyppönen, W. Iacono, B. Jacobsson, M. Järvelin, K. Jöckel, J. Kaprio, S. Kardia, T. Lehtimäki, Steven F. Lehrer, Patrik K. E. Magnusson, N. Martin, M. McGue, A. Metspalu, N. Pendleton, B. Penninx, M. Perola, N. Pirastu, Mario Pirastu, O. Polašek, D. Posthuma, Christine Power, M. A. Province, Nilesh J. Samani, D. Schlessinger, R. Schmidt, T. I. Sørensen, Timothy D. Spector, K. Stefánsson, U. Thorsteinsdóttir, A. Thurik, N. Timpson, Henning Tiemeier, J. Tung, A. Uitterlinden, V. Vitart, P. Vollenweider, David R. Weir, James F. Wilson, Alan F. Wright, D. Conley, Robert F. Krueger, G. D. Smith, A. Hofman, David Laibson, S. Medland, M. Meyer, Jian Yang, M. Johannesson, P. M. Visscher, T. Esko, P. Koellinger, D. Cesarini, D. Benjamin, Maris Alver, Y. Bao, D. Clark, F. Day, Peter K. Joshi, K. Kemper, A. Kleinman, C. Langenberg, J. Trampush, S. Verma, Yang Wu, M. Lam, J. Zhao, Zhili Zheng, J. Boardman, J. Freese, K. Harris, Caroline Hayward, P. Herd, M. Kumari, T. Lencz, J. Luan, A. Malhotra, L. Milani, K. Ong, J. Perry, M. Ritchie, M. Smart, Blair H. Smith, N. Wareham, James F. Wilson, J. Beauchamp, Patrik K. E. Magnusson, M. Robinson, Chelsea Watson, Jian Yang, M. Johannesson, P. M. Visscher, D. Benjamin +336 moresemanticscholar +1 more sourceEffect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees +6 morewiley +1 more source
