Results 151 to 160 of about 3,091,688 (344)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns

Genome Biology
Background Admixed populations offer valuable insight into the genetic architecture of complex traits. Many studies have proposed methods for genome-wide association study (GWAS) in admixed populations and various simulation studies have evaluated their ...
Hanbin Lee, Moo Hyuk Lee, Kangcheng Hou, Bogdan Pasaniuc, Buhm Han   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Genetic Risk Factors for Postoperative Atrial Fibrillation – a Nationwide Genome-Wide Association Study (GWAS) [PDF]

, 2022
Mathias A. Christensen, Alexander Bonde, Martin Sillesen   +2 more
openalex   +1 more source

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Science, 2006
R. Duerr, K. Taylor, S. Brant, S. Brant, J. Rioux, J. Rioux, M. Silverberg, M. J. Daly, M. J. Daly, A. Steinhart, C. Abraham, M. Regueiro, A. Griffiths, T. Dassopoulos, A. Bitton, Huiying Yang, S. Targan, L. Datta, E. Kistner, L. P. Schumm, Annette Lee, P. Gregersen, M. Barmada, J. Rotter, Dan L. Nicolae, Judy H. Cho   +25 more
semanticscholar   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Additional file 3 of Characterization of genome-wide association study data reveals spatiotemporal heterogeneity of mental disorders

, 2020
Yulin Dai, Timothy O’Brien, Guangsheng Pei, Zhongming Zhao, Peilin Jia   +4 more
openalex   +1 more source

B4-4: Genome-Wide Association Study of Macular Degeneration: Early Results from the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) [PDF]

, 2013
Eric Jorgenson, Stanley Sciortino, Ling Shen, Dilrini K. Ranatunga, Thomas J. Hoffmann, Mark Kvale, Yolan Banda, Pui–Yan Kwok, Lutz Walter, Neil Risch, Catherine Schaefer   +10 more
openalex   +1 more source

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Nature Network Boston, 2022
C. Tcheandjieu, Xiang Zhu, A. Hilliard, S. Clarke, V. Napolioni, Shining Ma, K. Lee, Huaying Fang, Fei Chen, Yingchang Lu, N. Tsao, S. Raghavan, S. Koyama, B. Gorman, M. Vujković, D. Klarin, M. Levin, Nasa Sinnott-Armstrong, G. Wojcik, M. Plomondon, T. Maddox, Stephen W. Waldo, A. Bick, S. Pyarajan, Jie Huang, Rebecca J Song, Y. Ho, S. Buyske, C. Kooperberg, J. Haessler, R. Loos, R. Do, M. Verbanck, K. Chaudhary, K. North, C. Avery, M. Graff, C. Haiman, L. Le Marchand, L. Wilkens, J. Bis, H. Leonard, Botong Shen, L. Lange, Ayush Giri, O. Dikilitas, I. Kullo, I. Stanaway, G. Jarvik, A. Gordon, S. Hebbring, B. Namjou, K. Kaufman, K. Ito, K. Ishigaki, Y. Kamatani, S. Verma, M. Ritchie, R. Kember, A. Baras, L. Lotta, S. Kathiresan, E. Hauser, Donald R Miller, Jennifer S. Lee, D. Saleheen, P. Reaven, Kelly Cho, J. Gaziano, P. Natarajan, J. Huffman, B. Voight, D. Rader, Kyong‐Mi Chang, J. Lynch, S. Damrauer, P. Wilson, Hua Tang, Yan V. Sun, P. Tsao, C. O’Donnell, T. Assimes   +81 more
semanticscholar   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source