Results 51 to 60 of about 3,155,630 (345)

Using Ontology Fingerprints to evaluate genome-wide association study results [PDF]

, 2009
We describe an approach to characterize genes or phenotypes via ontology fingerprints which are composed of Gene Ontology (GO) terms overrepresented among those PubMed abstracts linked to the genes or phenotypes. We then quantify the biological relevance
Lam C. Tsoi, Michael Boehnke, Richard L. Klein, W. Jim Zheng   +3 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Not so benign

eLife, 2018
Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.
Barbara Rivera
doaj   +1 more source

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. [PDF]

, 2015
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning.
Askland, KD, Bienvenu, OJ, Cullen, BA, Fyer, AJ, Geller, DA, Goes, FS, Grados, MA, Greenberg, BD, Knowles, JA, Lange, C, Liang, K-Y, Maher, B, Mattheisen, M, McCracken, JT, McLaughlin, NC, Murphy, DL, Nestadt, G, Nurmi, EL, Pauls, DL, Piacentini, J, Pulver, AE, Qin, H-D, Rasmussen, SA, Riddle, MA, Samuels, JF, Shugart, YY, Stewart, SE, Valle, D, Wang, Y   +28 more
core  

Genome-wide association study of endometrial cancer in E2C2 [PDF]

, 2013
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women.
Alison M. Dunning, Amanda B. Spurdle, Amanda Black, Anthony M. Magliocco, Brian E. Henderson, Carlotta Sacerdote, Christine M. Friedenreich, Christopher Haiman, Chu Chen, Constance Chen, David J. Hunter, David VanDen Berg, Deborah Thompson, Douglas F. Easton, Elizabeth Holliday, Fredrick Schumacher, Hannah P. Yang, Harvey Risch, Herbert Yu, Immaculata De Vivo, Irene Orlow, Jennifer Doherty, Jennifer Prescott, Jirong Long, Jodie N. Painter, John Attia, Jolanta Lissowska, Linda S. Cook, Lingeng Lu, Loic Le Marchand, Loreall Pooler, Louise Brinton, Lucy Xia, Mark McEvoy, Marta Crous-Bou, Mia M. Gaudet, Montserrat Garcia-Closas, Nicolas Wentzensen, Noel S. Weiss, null null, Pamela L. Horn-Ross, Patricia Hartge, Peter Kraft, Radhai Rastogi, Rodney J. Scott, Sara H. Olson, Stephen Chanock, Susan E. Hankinson, Timothy R. Rebbeck, Tracy A. O’Mara, Veronica Wendy Setiawan, Wei Zheng, Xiao-ou Shu, Xiaolin Liang, Xin Sheng, Yong-Bing Xiang   +55 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population

Clinical Epigenetics
Background While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA methylation, our understanding of ...
Ho-Sun Lee, Boram Kim, Taesung Park
doaj   +1 more source

A genomic‐based vision on the genetic diversity and key performance traits in selectively bred Arctic charr (Salvelinus alpinus)

Evolutionary Applications, 2022
Routine implementation of genomic information for guiding selection decisions is not yet common in the majority of aquaculture species. Reduced representation sequencing approaches offer a cost‐effective solution for obtaining genome‐wide information in ...
Christos Palaiokostas, Anam Anjum, Henrik Jeuthe, Khrystyna Kurta, Fernando Lopes Pinto, Dirk Jan deKoning   +5 more
doaj   +1 more source