Results 51 to 60 of about 3,210,341 (315)

Genome-Wide Profiling of Uncapped mRNA [PDF]

open access: yes, 2011
Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs.
Jiao, Yuling, Riechmann, José Luis
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis [PDF]

open access: yes, 2009
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration.
Sendtner, M.   +458 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

open access: yes, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris   +141 more
core   +1 more source

Genome wide identification of regulatory motifs in Bacillus subtilis

open access: yesBMC Bioinformatics, 2003
Background To explain the vastly different phenotypes exhibited by the same organism under different conditions, it is essential that we understand how the organism's genes are coordinately regulated.
Siggia Eric D, Mwangi Michael M
doaj   +1 more source

Genome-wide Clustering of Genes

open access: yes, 2020
With the development of 500K chips, i.e. approximately 500.000 single nucleotide polymorphisms per individual, the quantity and quality of data in genetic researches have risen considerably. As the amount of data makes it hard for any researcher to identify genes and SNPs that are relevant for a specific research problem, it is necessary to organize ...
openaire   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

open access: yes, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C   +9 more
core  

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium [PDF]

open access: yes, 2011
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease.
Marsit CJ   +934 more
core   +1 more source

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