Results 61 to 70 of about 845,626 (266)

Characteristics of Gastric Endoscopic and Histopathological Findings in the South and Southeast Asian Populations

JGH Open
Background and Aim Helicobacter pylori infection rates and severity and susceptibility to gastric diseases vary widely in different populations because of different H. pylori strains, lifestyles, and genetic factors.
Mitsushige Sugimoto, Takeshi Matsuhisa, Hafeza Aftab, Sirikan Limpakan, Sunil K. Sharma Dhakal, Kim Sang, Kyaw Htet, Than Than Yee, Yoshio Yamaoka   +8 more
doaj   +1 more source

Genome-wide association mapping identifies

Industrial Crops and Products
Resistance to the necrotrophic pathogen Rhizoctonia solani is a major bottleneck in cotton breeding, hindered by the lack of resistance germplasm, accurate phenotyping methods, and defined resistance genes.
Peng Wu, Chenglin Liu, Dingyi Yang, Xinyi Li, Junyuan Lv, Yuqing Ming, Wanyin Xu, Xiaojun Zhang, Weiran Wang, Ping Du, Mingde Wu, Wei Gao, Jie Kong, Xinhui Nie, Chunyuan You, Xiaoping Guo, Haiquan Zhao, Ling Min, Xianlong Zhang, Hui Xi, Shiming Liu, Longfu Zhu   +21 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Simulating variance heterogeneity in quantitative genome wide association studies

BMC Bioinformatics, 2018
Background Analyzing Variance heterogeneity in genome wide association studies (vGWAS) is an emerging approach for detecting genetic loci involved in gene-gene and gene-environment interactions.
Ahmad Al Kawam, Mustafa Alshawaqfeh, James J. Cai, Erchin Serpedin, Aniruddha Datta   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Genome-wide mapping of the

iScience
Summary: Galleria mellonella is an emerging experimental model, but its current genome annotation lacks transcription start site (TSS) information. Because TSS annotation is essential for understanding transcriptional regulation, we used low quantity ...
Imad Abugessaisa, Mickey Konings, Ri-ichiroh Manabe, Michihira Tagami, Jessica Severin, Akira Hasegawa, Tsugumi Kawashima, Hiroko Kinoshita, Shohei Noma, Chitose Takahashi, Annelies Verbon, Yasushi Okazaki, Wendy W.J. van de Sande, Takeya Kasukawa   +13 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Genome-wide characterization of the

Scientia Horticulturae
The AT-HOOK MOTIF NUCLEAR-LOCALIZED ( AHL ) gene family plays crucial roles in plant growth and development, environmental stress responses, and hormone signaling.
Juan Xie, Hongkun Wang, Jiahui Liang, Xu Zhou, Kaifu Xiao, Huazhao Yuan, Linlin Xu, Ejiao Wu, Chengwen Zong, Yushan Qiao, Li Cao   +10 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source