Results 261 to 270 of about 25,267,477 (304)

Genome-wide analysis of structural variation

Nature Methods, 2021
Phased genomes from diverse human populations are assembled using multiple sequencing technologies.
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Genome-wide analysis of HDAC function

Trends in Genetics, 2005
This article focuses on new developments in the genome-wide analysis of histone deacetylase (HDAC) function in yeast. HDACs are highly conserved in many organisms; therefore, their basic functions can be investigated using experimentally tractable model organisms, such as the budding yeast Saccharomyces cerevisiae and the fission yeast ...
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Genome-wide pathway analysis of a genome-wide association study on Alzheimer’s disease

Neurological Sciences, 2014
The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of Alzheimer's disease (AD) and to generate SNP to gene to pathway hypotheses. An AD genome-wide association study (GWAS) dataset that included 370,542 SNPs in 1,000 cases and 1,000 controls of European descent was used in this study.
Young Ho, Lee, Gwan Gyu, Song
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Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis

Molecular Biology Reports, 2012
The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of multiple sclerosis (MS) and to generate SNP to gene to pathway hypotheses. A MS genome-wide association study (GWAS) dataset that included 505,763 SNPs in 500 cases and 500 controls of European descent was used in this study.
Gwan Gyu, Song, Sung Jae, Choi, Jong Dae, Ji, Young Ho, Lee   +3 more
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Genome‐Wide Analysis of Epigenetics in Cancer

Annals of the New York Academy of Sciences, 2003
Abstract: Human cancers are caused by multiple mechanisms. Research in the last 30 years has firmly established the roles of a group of genes including oncogenes, tumor suppressor genes, and DNA repair genes in human cancers. The activation and inactivation of these cancer genes can be caused by genetic mutations or epigenetic alterations.
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Analysis of Genome-Wide Association Data

2016
The last decade has seen substantial advances in the understanding of the genetics of complex traits and disease. This has been largely driven by genome-wide association studies (GWAS), which have identified thousands of genetic loci associated with these traits and disease.
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GENOME-WIDE ANALYSIS OF BACTERIAL PROMOTER REGIONS

Biocomputing 2003, 2002
Identifying prokaryotic promoter sequences is notoriously difficult and for most sequenced bacterial genomes the promoter sequences are still unknown. Since experimental analysis trails behind sequencing, genome-wide computational promoter discovery is often the only realistic way to discover these sequences in newly sequenced bacterial genomes ...
Eleazar Eskin, Uri Keich, Mikhail S. Gelfand, Pavel A. Pevzner   +3 more
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Genome-Wide Analysis of Yeast Aging

2011
In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome and advances in genomic technologies have opened yeast research to genome-scale screens for a variety of phenotypes.
George L, Sutphin, Brady A, Olsen, Brian K, Kennedy, Matt, Kaeberlein   +3 more
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Genome-Wide Analysis of Epigenetic Modifications

Journal of Computer Science and Technology, 2010
In plants and animals, gene expression can be altered by changes that do not alter the sequence of nucleotides in DNA but rather modify the chemical structure of either the DNA or the histones that interact with the DNA. These so-called epigenetic modifications are not transient, but persist through cell divisions.
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Analysis of Genome-Wide Association Studies

Genome-wide association studies (GWAS) aim to identify genetic variants across the whole genome associated with the phenotype of interest. This technique has been largely used in the bone field to elucidate the genetic architecture of complex traits, like bone mineral density or fracture risk, and to date, more than 600 loci have been identified.
Piyush, Gampawar, Edith, Hofer, Nerea, Alonso   +2 more
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