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Methylated DNA Immunoprecipitation Genome-Wide Analysis
2011DNA methylation is an important and potentially heritable component of the epigenetic machinery that has a major role in the control of gene expression and can be deregulated in many diseases. This modification of genomic DNA can be assessed using the methylated DNA immunoprecipitation (MeDIP) method, based on the quantification of methylated DNA ...
Pelizzola M, Molinaro A
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Genome-Wide Proximal Promoter Analysis and Interpretation
2009High-throughput gene expression technologies based on DNA microarrays allow the examination of biological systems. However, the interpretation of the complex molecular descriptions generated by these approaches is still challenging. The development of new methodologies to identify common regulatory mechanisms involved in the control of the expression ...
Corrales, F.J. (Fernando José) +3 more
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A platform for genome-wide analysis
2011 IEEE International Symposium on IT in Medicine and Education, 2011By integrating most tools and websites of genome-wide analysis, a platform has been developed to provide simple sequences analysis for researchers to teach and independently study. Presently, more and more researchers focus their attention on genetic area, yet it is still challenging for biomedical researchers to access and analyze the exponentially ...
null Xuan Si +3 more
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Genome-Wide Functional Analysis
Science's STKE, 2004An RNA interference-based screen on a genome-wide scale is likely to become one of the methods of choice for comprehensive functional genomic analysis because of its potential to identify, rapidly and systematically, genes that control a variety of cellular processes. Boutros et al. conducted such a screen of the
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Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet’s disease
Molecular Biology Reports, 2011The aim of this study was to identify candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of psoriasis and Behcets's disease (BD) and to generate an SNP → gene → pathway hypothesis. A psoriasis genome-wide association study (GWAS) dataset that included 436,192 SNPs in 1,409 psoriasis cases and 1,436 controls of ...
Young Ho, Lee +3 more
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Meta-Analysis of Genome-Wide Association Studies
Cold Spring Harbor Protocols, 2010INTRODUCTIONIndividual genome-wide association studies have only limited power to find novel loci underlying complex traits and common diseases. With relatively modest sample and effect sizes, a true association between genotype and phenotype may never meet genome-wide statistical significance (P < 5 × 10-8) in a single study. Through meta-analysis,
Paul I W, de Bakker +2 more
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Tuning ReliefF for Genome-Wide Genetic Analysis
2007An important goal of human genetics is the identification of DNA sequence variations that are predictive of who is at risk for various common diseases. The focus of the present study is on the challenge of detecting and characterizing nonlinear attribute interactions or dependencies in the context of a genome-wide genetic study.
Jason H. Moore, Bill C. White
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