Genome-wide analysis reveals coating of the mitochondrial genome by TFAM. [PDF]
PLoS ONE, 2013 Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids containing both DNA and proteins, including the machinery required for mtDNA replication and ...
Yun E Wang +3 more
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Genome-Wide Transcriptome Analysis in Type 2 Diabetes Patients Treated by Sitagliptin
Diabetes, Metabolic Syndrome and Obesity, 2022 Rui Ma,1 Xiao-long Deng,2 Qi-qi-ge Aleteng,1 Lei Li,1 Jun Zhu3 1Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, People’s Republic of China; 2Department of Endocrinology, Shunde Hospital
Ma R, Deng X, Aleteng Q, Li L, Zhu J
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Genome‑wide analysis of the MYB gene family in pumpkin [PDF]
PeerJThe MYB gene family exerts significant influence over various biological processes and stress responses in plants. Despite this, a comprehensive analysis of this gene family in pumpkin remains absent.
Minyan Xu +3 more
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Genome wide identification of recessive cancer genes by combinatorial mutation analysis. [PDF]
PLoS ONE, 2008 We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene ...
Stefano Volinia +8 more
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Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.
PLoS Genetics, 2019 Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).
Nicole F Liachko +6 more
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Genome wide molecular analysis of minimally differentiated acute myeloid leukemia
Haematologica, 2009 Background Minimally differentiated acute myeloid leukemia is heterogeneous in karyotype and is defined by immature morphological and molecular characteristics.
Fernando P.G. Silva +12 more
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Genome-Wide Gene-Based Multi-Trait Analysis
Frontiers in Genetics, 2020 Genome-wide association studies focusing on a single phenotype have been broadly conducted to identify genetic variants associated with a complex disease.
Yamin Deng +5 more
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Massively expedited genome-wide heritability analysis (MEGHA) [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Practical tools for high-dimensional heritability-based screening are invaluable for prioritizing phenotypes for genetic studies with the dramatic expansion of available phenotypic data. Classical estimates of heritability require twin or pedigree data, which can be costly and difficult to acquire.
Ge, Tian +7 more
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Genome‐wide analysis of the AP2/ERF gene family inSalix arbutifolia
FEBS Open Bio, 2015 AP2/ERF genes encode transcriptional regulators with a variety of functions in plant growth and development and in response to biotic and abiotic stresses.
Guodong Rao +4 more
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Approximate conditional phenotype analysis based on genome wide association summary statistics
Scientific Reports, 2021 Because single genetic variants may have pleiotropic effects, one trait can be a confounder in a genome-wide association study (GWAS) that aims to identify loci associated with another trait.
Peitao Wu +5 more
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