Results 31 to 40 of about 732,792 (264)

Meta-Analysis in Genome-Wide Association Studies [PDF]

Pharmacogenomics, 2009
The advent of genome-wide association studies has allowed considerable progress in the identification and robust replication of common gene variants that confer susceptibility to common diseases and other phenotypes of interest. These genetic effect sizes are almost invariably moderate to small in magnitude and single studies, even if large, are ...
Zeggini, E., Ioannidis, J. P.
openaire   +3 more sources

Comprehensive Analysis of SiNPs on the Genome-Wide Transcriptional Changes in Caenorhabditis elegans

International Journal of Nanomedicine, 2020
Shuang Liang,1,2,* Junchao Duan,1,2,* Hejing Hu,1,2 Jingyi Zhang,1,2 Shan Gao,2,3 Haiming Jing,2,3 Guojun Li,2,3 Zhiwei Sun1,2 1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, People ...
Liang S, Duan J, Hu H, Zhang J, Gao S, Jing H, Li G, Sun Z   +7 more
doaj  

Pathway analysis comparison using Crohn's disease genome wide association studies

BMC Medical Genomics, 2010
Background The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have
Cho Judy, Abraham Clara, Ballard David, Zhao Hongyu   +3 more
doaj   +1 more source

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Functional analysis of glial genome-wide expression

Frontiers in Cellular Neuroscience, 2015
Modern neurosciences have benefited from the recent development of high-throughput experimental platforms that allow the parallel analysis of thousands of molecules or regions of interest.
Diego Forero
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

SuperDCA for genome-wide epistasis analysis

Microbial Genomics, 2017
The potential for genome-wide modelling of epistasis has recently surfaced given the possibility of sequencing densely sampled populations and the emerging families of statistical interaction models. Direct coupling analysis (DCA) has previously been shown to yield valuable predictions for single protein structures, and has ...
Pesonen, Maiju, Pensar, Johan, Xu, Yingying, Lees, John A., Bentley, Stephen, Croucher, Nicholas J, Corander, Jukka, Puranen, Santeri   +8 more
openaire   +5 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Genome wide association analysis in a mouse advanced intercross line

Nature Communications, 2018
Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis.
Natalia M. Gonzales, Jungkyun Seo, Ana I. Hernandez Cordero, Celine L. St. Pierre, Jennifer S. Gregory, Margaret G. Distler, Mark Abney, Stefan Canzar, Arimantas Lionikas, Abraham A. Palmer   +9 more
doaj   +1 more source

Genome-wide haplotype analysis

Sri Lanka Journal of Bio-Medical Informatics, 2013
This literature review was done with the objective of reviewing the genome-wide haplotype analyses which have been already carried out globally. After the completion of the human genome project, several studies on haplotype analysis on various aspects have been published. Such knowledge may provide valuable information on human evolutionary history and
openaire   +2 more sources