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Genetic dissection of gluten characteristics based on single- and multi-locus genome-wide association studies in wheat (<i>Triticum aestivum</i> L.). [PDF]
Jiang X +5 more
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The Impact of Ancestry on Genome-Wide Association Studies. [PDF]
Jones SC +4 more
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Extending Genome-Wide Association Studies to admixed cohorts with high degrees of relatedness
Tan T +13 more
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Genome-Wide Association Studies
JAMA, 2019Abstract Genome-wide association studies (GWAS) have evolved over the past ten years into a very successful tool for investigating the genetic architecture of multifactorial human traits and disorders. One major advantage of GWAS is that they do not require any a priori knowledge about the biological mechanisms underlying the traits and ...
Xiuqing, Guo, Jerome I, Rotter
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Genome-Wide Association Studies
2010Genome-wide association (GWA) studies are best understood as an extension of candidate gene association studies, scaled up to cover hundreds of thousands of markers across the genome in samples usually of several thousand cases and controls. The GWA approach allows the detection of much smaller effect sizes than with previous linkage-based genome-wide ...
Paola Sebastiani, Nadia Solovieff
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Genome-Wide Association Studies (GWAS)
2023Most of the breeding targets are quantitative traits. In exploring the quantitative trait locus (QTL) system of a trait, linkage mapping was established using sparse polymerase chain reaction (PCR) markers. With the genome-wide sequencing technology advanced, genome-wide association study (GWAS) was developed for natural (germplasm) populations using ...
Jianbo, He, Junyi, Gai
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Genome-Wide Association Studies
2012A host of data on genetic variation from the Human Genome and International HapMap projects, and advances in high-throughput genotyping technologies, have made genome-wide association (GWA) studies technically feasible. GWA studies help in the discovery and quantification of the genetic components of disease risks, many of which have not been unveiled ...
Tun-Hsiang, Yang +2 more
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Family-Based Genome-Wide Association Studies
Pharmacogenomics, 2009In the last 2 years, the effort to identify genes affecting common diseases and complex traits has been accelerated through the use of genome-wide association studies (GWAS). The availability of existing large collections of linkage data paved the way for the use of family-based GWAS.
Benyamin, Beben +2 more
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