Revealing the Shared Genetic Architecture of Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Traits Through Genomic Structural Equation Modeling. [PDF]
Genet EpidemiolDong H +5 more
europepmc +1 more source
Genetically Proxied GIP‐GIPR Pathway Perturbation and Fracture Risk
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To determine whether genetic proxies for incretin pathway perturbation are associated with fracture risk and bone mineral density, providing human genetic evidence relevant to the skeletal safety of incretin‐based therapies. Materials and Methods We conducted drug‐target Mendelian randomisation using cis genetic variants near GIP, GIPR ...
Wenjie Cheng +5 more
wiley +1 more source
Genetic Determinants of Tau-PET Imaging in Alzheimer's Disease: A Narrative Review of Genome-Wide and Candidate-Gene Studies. [PDF]
J ImagingGujral J +8 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley +1 more source
Individualized Bayesian Inference Identifies Novel Genetic Variants for Parkinson's Disease. [PDF]
Genet EpidemiolRen J, Soofi YJ, Rahman MA, Lu Q, Liu J.
europepmc +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
The FEBS Journal, EarlyView.AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source
FGF-23 is associated with increased risk of abdominal aortic calcification: A Mendelian randomization study with phosphate as a potential mediator. [PDF]
Medicine (Baltimore)Song L +5 more
europepmc +1 more source
Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer
The FEBS Journal, EarlyView.Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa +2 more
wiley +1 more source
High-Density Genome-Wide Association Mapping Identifies Candidate Loci Associated with Maize Stalk Cell Wall Composition. [PDF]
Plants (Basel)Ren Y, Zhang J, Tian Q, Liu X.
europepmc +1 more source
International Journal of Immunogenetics, EarlyView.ABSTRACT Genetic factors that modulate immune regulation are increasingly recognised as contributors to the heterogeneity and clinical course of autoimmune diseases. Polymorphisms of protein tyrosine phosphatase non‐receptor type 22 (PTPN22) are associated with several autoimmune diseases.
Sonja Kvist +5 more
wiley +1 more source