Results 41 to 50 of about 22,244,058 (261)

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.

open access: yesPLoS Genetics, 2012
More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively ...
Christina M Lill   +57 more
doaj   +1 more source

Sequencing-based genome-wide association studies reporting standards

open access: yesCell Genomics, 2021
Summary: Genome sequencing has recently become a viable genotyping technology for use in genome-wide association studies (GWASs), offering the potential to analyze a broader range of genome-wide variation, including rare variants.
Aoife McMahon   +9 more
doaj   +1 more source

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a) [PDF]

open access: yes, 2012
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the ...
Postmus, Iris   +65 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

PP-GWAS: Privacy Preserving Multi-Site Genome-wide Association Studies

open access: yesNature Communications
Genome-wide association studies help uncover genetic influences on complex traits and diseases. Importantly, multi-site data collaborations enhance the statistical power of these studies but pose challenges due to the sensitivity of genomic data ...
Arjhun Swaminathan   +4 more
doaj   +1 more source

A genome-wide association search for type 2 diabetes genes in African Americans [PDF]

open access: yes, 2011
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Bostrom, Meredith A   +999 more
core   +5 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Biparental Crossing and QTL Mapping for Validation of Genome-Wide Association Studies

open access: yes, 2022
Association mapping (AM), also known as genome-wide association studies (GWAS), is increasingly being employed in crop plants for the identification of QTL/genes and marker–trait associations (MTAs) in natural populations.
Singh, R, Kulwal, PL
core   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai   +13 more
wiley   +1 more source

Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel

open access: yesBMC Genomics
Disequilibrium is a highly prevalent age-related condition that increases fall risk, yet the genetic architecture underlying vestibular function remains poorly defined.
Yuzuru Ninoyu   +13 more
doaj   +1 more source

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