Results 31 to 40 of about 22,244,058 (261)

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]

open access: yes, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
Herrington, D.M.   +627 more
core   +2 more sources

Robust Reference Powered Association Test of Genome-Wide Association Studies

open access: yesFrontiers in Genetics, 2019
Genome-wide association studies (GWASs) have identified abundant genetic susceptibility loci, GWAS of small sample size are far less from meeting the previous expectations due to low statistical power and false positive results.
Yi Wang   +16 more
doaj   +1 more source

A cross-tissue transcriptome association study identifies key genes in essential hypertension

open access: yesFrontiers in Genetics, 2023
Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative
Sihui Huang   +14 more
doaj   +1 more source

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

open access: yesNature Communications, 2018
Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS).
Nilah M. Ioannidis   +8 more
doaj   +1 more source

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

open access: yesMicrobiome, 2018
Background In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases.
Jun Wang   +26 more
doaj   +1 more source

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

open access: yes, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N.   +181 more
core   +1 more source

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

open access: yesNature Communications, 2019
“Genome-wide association studies have identified variants associated with age-related macular degeneration (AMD); however, other than identifying this as a complement mediated inflammatory disease, little biology has emerged.
Madhvi Menon   +10 more
doaj   +1 more source

First genome-wide association study on anxiety-related behaviours in childhood [PDF]

open access: yes, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B.   +66 more
core   +1 more source

Genome-wide association and functional follow-up reveals new loci for kidney function [PDF]

open access: yes, 2012
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new
Döring, Angela   +999 more
core   +2 more sources

Integrative genomic profiling identifies MLPH as a candidate gene in prostate cancer

open access: yesFrontiers in Medicine
BackgroundProstate cancer (PCa) is a highly heterogeneous malignancy with complex genetic underpinnings. This study integrates multi-omics data to prioritize candidate susceptibility genes and evaluate their functional and clinical significance in PCa ...
Runyi Wang   +7 more
doaj   +1 more source

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