Results 11 to 20 of about 22,244,058 (261)

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. [PDF]

open access: yesPLoS ONE, 2010
BackgroundLate Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the ...
Lesley Jones   +83 more
doaj   +3 more sources

I-GWAS: Privacy-Preserving Interdependent Genome-Wide Association Studies

open access: yes, 2022
Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals.
Decouchant, Jérémie (author)   +3 more
core   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

open access: yes, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny   +58 more
core   +1 more source

A genome-wide association search for type 2 diabetes genes in African Americans. [PDF]

open access: yes, 2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Kumari, Meena   +389 more
core   +3 more sources

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

open access: yes, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo   +928 more
core   +1 more source

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

open access: yes, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J.   +585 more
core   +2 more sources

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci [PDF]

open access: yes, 2013
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat
Burke, Gregory L.   +431 more
core   +1 more source

Genome-wide association study of receptive language ability of 12 year olds [PDF]

open access: yes, 2013
Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...
Hanscombe, K.B.   +32 more
core   +1 more source

Identification of heel bone mineral density as a risk factor of Alzheimer’s disease by analyzing large-scale genome-wide association studies datasets

open access: yesFrontiers in Cell and Developmental Biology, 2023
Introduction: Both low bone mineral density (BMD) and Alzheimer’s disease (AD) commonly co_occur in the older adult. Until now, the association between AD and BMD has been widely reported by observational studies.
Feng Gao   +4 more
doaj   +1 more source

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. [PDF]

open access: yes, 2011
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA.
Keating, BJ   +999 more
core   +2 more sources

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