Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]
, 2019 BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas +5 more
core +3 more sources
The Role of Family-Based Designs in Genome-Wide Association Studies [PDF]
, 2009 Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs.
Laird, Nan M., Lange, Christoph
core +1 more source
A Genome-Wide Association Study (GWAS) for Bronchopulmonary Dysplasia [PDF]
Pediatrics, 2013 OBJECTIVE: Twin studies suggest that heritability of moderate-severe bronchopulmonary dysplasia (BPD) is 53% to 79%, we conducted a genome-wide association study (GWAS) to identify genetic variants associated with the risk for BPD.
Wang, Hui +12 more
openaire +5 more sources
A foundation for provitamin A biofortification of maize: genome-wide association and genomic prediction models of carotenoid levels. [PDF]
, 2014 Efforts are underway for development of crops with improved levels of provitamin A carotenoids to help combat dietary vitamin A deficiency. As a global staple crop with considerable variation in kernel carotenoid composition, maize (Zea mays L.) could ...
Buckler, Edward S +13 more
core +1 more source
Genome-wide association studies in Plasmodium species [PDF]
, 2010 Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be ...
Bridget Penman +3 more
core +3 more sources
Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction
BMC Research Notes, 2023 Objective To use genome-wide association study (GWAS) by subtraction, a method for deriving novel GWASs from existing summary statistics, to derive genome-wide summary statistics for paternal smoking.
Benjamin Woolf +3 more
doaj +1 more source
Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance
Frontiers in Microbiology, 2023 Quinolone resistance presents a growing global health threat. We employed word-based GWAS to explore genomic data, aiming to enhance our understanding of this phenomenon.
Negin Malekian +5 more
doaj +1 more source
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript [PDF]
, 2011 Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate susceptibility gene, KLK3, which encodes prostate-specific antigen (PSA)
Kote-Jarai, Z. +30 more
core +2 more sources
Multi-locus genome-wide association studies for five yield-related traits in rice
BMC Plant Biology, 2021 Background Improving the overall production of rice with high quality is a major target of breeders. Mining potential yield-related loci have been geared towards developing efficient rice breeding strategies.
Hua Zhong +6 more
doaj +1 more source
A cross-tissue transcriptome association study identifies key genes in essential hypertension
Frontiers in Genetics, 2023 Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative
Sihui Huang +14 more
doaj +1 more source