Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. [PDF]
PLoS ONE, 2012 The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple
Jörg Hager +26 more
doaj +3 more sources
Editorial: Statistical methods for genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) and their applications [PDF]
Frontiers in Genetics, 2023 Mengting Shao +6 more
doaj +2 more sources
A Review of Prostate Cancer Genome-Wide Association Studies (GWAS). [PDF]
Cancer Epidemiol Biomarkers Prev, 2018 Abstract Prostate cancer is the most common cancer in men in Europe and the United States. The genetic heritability of prostate cancer is contributed to by both rarely occurring genetic variants with higher penetrance and moderate to commonly occurring variants conferring lower risks.
Benafif S +3 more
europepmc +5 more sources
A BAYESIAN GRAPHICAL MODEL FOR GENOME-WIDE ASSOCIATION STUDIES (GWAS). [PDF]
Ann Appl Stat, 2016 The analysis of GWAS data has long been restricted to simple models that cannot fully capture the genetic architecture of complex human diseases. As a shift from standard approaches, we propose here a general statistical framework for multi-SNP analysis of GWAS data based on a Bayesian graphical model.
Briollais L +5 more
europepmc +4 more sources
I-GWAS: Privacy-Preserving Interdependent Genome-Wide Association Studies [PDF]
Proceedings on Privacy Enhancing Technologies, 2023 Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals. Unfortunately, careless sharing of GWAS statistics might give rise to privacy attacks.
Túlio Pascoal +3 more
openalex +6 more sources
Genome-wide association studies (GWAS) and their importance in asthma
Allergologia et Immunopathologia, 2014 Asthma is a complex disease determined by the interaction of different genes and environmental factors. The first genetic investigations in asthma were candidate gene association studies and linkage studies. In recent years research has focused on association studies that scan the entire genome without any prior conditioning hypothesis: the so-called ...
Asunción Garcı́a-Sánchez +7 more
openalex +5 more sources
Genome-Wide Association Studies (GWAS) and Transcriptome Analysis Reveal Male Heterogametic Sex-Determining Regions and Candidate Genes in Northern Snakeheads (Channa argus). [PDF]
Int J Mol SciLiu H +9 more
europepmc +3 more sources
Genome-wide association study (GWAS) approaches to sleep phenotypes [PDF]
, 2013 Patrick Sleiman +2 more
openalex +2 more sources
Genome-wide Studies of knee Osteoarthritis: Review [PDF]
Travmatologiâ i Ortopediâ Rossii, 2021 Background. Knee osteoarthritis (OA) is a multifactorial disease resulting from the interaction of many environmental, epigenetic and genetic risk factors, and the latter account for 40% to 65%.
Vitaly B. Novakov +2 more
doaj +1 more source