Results 51 to 60 of about 22,244,058 (261)

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits [PDF]

, 2011
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ...
Palmer Cameron D., Schwartz, SM, Benjamin F Voight, Fox, Caroline S., Hwang, Shih-Jen, GIANT Consortium, Launer, Lenore, Hernaez, R, Melissa E. Garcia, Hwang, SJ, Pietiläinen, Kirsi Hannele, Harris, Tamara B, Mitchell, Braxton D., CRISPONI, LAURA, Butler, Johannah L, Massaro, J.M., Gudnason, V., Feitosa, MF, Jeanne M. Clark, Massaro, J., Jørgensen, Torben, O'Donnell Christopher J., Stephen M. Schwartz, Schwartz SM, Palmer, C., Eiriksdottir, Gudny, Joel N Hirschhorn, Kao W. H. Linda, Laura M. Yerges-Armstrong, Stephen M Schwartz, Jeanne M Clark, Borecki Ingrid B., Mitchell, Braxton, Smith, AV, null null, Palmer, C.D., Kao, W.H.L., Johannah L. Butler, Butler, Johannah L., Borecki, IB, Palmer CD, Salomaa, V., Hirschhorn, Joel, Borecki, Ingrid B., Johannah L Butler, Speliotes, Elizabeth K, Fox Caroline S., Shuldiner, Alan R., Fox CS, Hoffmann, Udo, Palmer, CD, Nalls, Michael, Garcia, Melissa E, Hwang SJ, Wu, Jun, Mary F Feitosa, Massaro, Joseph M., Eiriksdottir G, Schadt, EE, Voight, Benjamin F, Nalls, Michael A., Clark, Jeanne M., Eiriksdottir, G, Smith AV, O'Donnell, CJ, Sahani DV, NASH CRN, Schwartz Stephen M., Lauren J Kim, CJ, Butler Johannah L., Speliotes, Elizabeth K., Tamara B Harris, Speliotes, E.K., Feitosa, Mary F., Joseph M. Massaro, Caroline S. Fox, Smith, Albert V, Launer, Lenore J, Shuldiner Alan R., GOLD Consortium, Hoffmann, U, Harris, Tamara, Tamara B. Harris, Garcia Melissa E., Kao, W. H Linda, Albert V. Smith, Mitchell BD, Smith, A.V., Voight, BF, Voight, Benjamin F., Mary F. Feitosa, Alan R Shuldiner, Kim, L.J., Kao, W H Linda, Speliotes EK, Siscovick, DS, Schadt, Eric E., Fox, C.S., Vilmundur Gudnason, Sahani, Dushyant V, Ruben Hernaez, Raychaudhuri, Soumya, Cameron D Palmer, Dushyant V Sahani, Salomaa, Veikko, O'Donnell, Christopher J., Feitosa, Mary, Shuldiner AR, Carr, J Jeffrey, Harris, T.B., Speliotes Elizabeth K., Salomaa, V, Posthuma, D., Tomas, Marta, Palmer, Cameron D, Tomas, M, Wu Jun, Siscovick David S., Launer Lenore J., Palmer, Cameron, et al., de Geus, E.J.C.; id_orcid, Butler, J.L., Clark Jeanne M., Hernaez, R., Mitchell, Braxton D, Borecki, Ingrid B, Shuldiner, A.R., Voight Benjamin F., Benjamin F. Voight, Kao, WH Linda, Lenore J. Launer, Feitosa MF, Siscovick, David, Nalls, M.A., Carr, J. Jeffrey, Clark, JM, Garcia, Melissa E., Lenore J Launer, Hirschhorn Joel N., Hwang, S.J., Eiriksdottir, G., Launer, L.J., Laura M Yerges-Armstrong, Melissa E Garcia, Hwang, S., Christopher J O'Donnell, Yerges-Armstrong, Laura M., Clark, J., Kim Lauren J., Launer, Lenore J., Hirschhorn JN, Harris, Tamara B., Michael A. Nalls, Launer LJ, Boomsma, D.I.; id_orcid, J Jeffrey Carr, Massaro, JM, Braxton D. Mitchell, Posthuma, D.; id_orcid, Heijer, M. den, Shih-Jen Hwang, Siscovick, David S., Mitchell, BD, Siscovick DS, Gudnason V, Yerges-Armstrong, L.M., Launer, LJ (Lenore), Gudnason, Vilmundur, Veikko Salomaa, de Geus, E.J.C., O' DONNELL, Willemsen, G.; id_orcid, Mitchell, B., Shuldiner, Alan, Kim, Lauren J, Sahani Dushyant V., Smith Albert V., David S Siscovick, Schadt, Eric, Kao WH, Fox, CS, David S. Siscovick, Carr JJ, Butler, Johannah, Massaro, Joseph, Hoffmann U, Garcia, Melissa, Tomas Marta, Mitchell Braxton D., Christopher J. O'Donnell, Lokki, Marja-Liisa, Gudnason Vilmundur, Fox, Caroline, DIAGRAM Consortium, Schadt, E.E., Tomas M, Hirschhorn, J.N., Jun Wu, Nalls, M., Ingrid B Borecki, Launer, L., Harris TB, Palmer, Cameron D., O'Donnell, C.J., Nalls MA, Voight BF, Borecki IB, Salomaa V, Massaro, Joseph M, Voight, B.F., Nalls, MA, O'Donnell, Christopher J, Garcia, M., Harris Tamara B., Kao, W., Kao, WH, Elizabeth K Speliotes, Gudnason, V, Siscovick, D.S., Yerges-Armstrong, Laura, Siscovick, David S, Cameron D. Palmer, Smith, Albert, Garcia ME, Marta Tomas, Clark, Jeanne M, Eric E. Schadt, Hottenga, J.J., Wu, J, Caroline S Fox, Joel N. Hirschhorn, Wu, J., Hoffmann Udo, Schadt EE, Albert V Smith, Carr J. Jeffrey, Sahani, D.V., J. Jeffrey Carr, Michael A Nalls, Feitosa, Mary F, Kao, W.H., O'Donnell, Christopher, Kim LJ, Nalls Michael A., Feitosa Mary F., Schwartz, S.M., Smith, Albert V., Shuldiner, Alan R, Voight, Benjamin, Wu J, Alan R. Shuldiner, Borecki, Ingrid, Massaro Joseph M., Lauren J. Kim, Schwartz, Stephen M, SCUTERI, ANGELO, Kao, WHL, Speliotes, Elizabeth, Kim, LJ, Clark, Jeanne, Carr, J.J., Nalls, Michael A, Feitosa, M.F., Harris, TB, Willemsen, G., Hirschhorn, Joel N., Clark JM, Yerges-Armstrong, L., Ingrid B. Borecki, Eric E Schadt, Butler, J., Butler JL, Schwartz, Stephen, Yerges-Armstrong LM, Garcia, M.E., Hernaez Ruben, Shuldiner, AR, GIANT, Boomsma, D.I., Kim, L., Elizabeth K. Speliotes, O’Donnell, C., Clark, J.M., Yerges-Armstrong, Laura M, Kim, Lauren J., Garcia, ME, Joseph M Massaro, Mitchell, B.D., Massaro JM, Speliotes, EK, Kim, Lauren, Udo Hoffmann, Jansson, John-Olov,, W H Linda Kao, MAGIC Investigators, Launer, LJ, Shuldiner, A., Hirschhorn, Joel N, Salomaa Veikko, Dushyant V. Sahani, Hwang Shih-Jen, Tomas, M., Hernaez R, Geus, E.J.C. de, Borecki, I.B., Kao, W. H. Linda, Hwang, Shih Jen, Butler, JL, Sahani, Dushyant, Hirschhorn, JN, Sahani, Dushyant V., Speliotes, E., YERGES ARMSTRONG LM, Yerges-Armstrong Laura M., Hernaez, Ruben, Eiriksdottir Gudny, Sahani, DV, Gudny Eiriksdottir, Braxton D Mitchell, Schadt Eric E., Schadt, Eric E, Hoffmann, U., PAOLISSO, Giuseppe, Schwartz, Stephen M., W. H. Linda Kao, Carr, JJ, Yerges-Armstrong, LM, Fox, Caroline S, Kaplan, Robert C., Chalasani, Naga, Welch, Ryan, Assimes, Themistocles L., Sanna, Serena, Teslovich, Tanya M., Hengstenberg, Christian, Zgaga, Lina, Dasarathy, Srinivasan, Peters, Annette, Gyurkey, Grace, Kaprio, Jaakko, Ketkar, Shamika, Navarro, Pau, Qi, Lu, Monda, Keri L., Gejman, Pablo V., Lawrence, Robert W., Abecasis, Gonçalo R., Diehl, Anna Mae, White, Melanie, Valle, Timo T., Facheris, Maurizio F., Frayling, Timothy M., Jarvelin, Marjo-Riitta, Liu, Jianjun, Piercy, Dawn, Ludwig, Barbara, Wang, Chia, Killenberg, Paul, Kilpeläinen, Tuomas O., Almgren, Peter, Balmforth, Anthony J., Huikuri, Heikki V., Gräβler, Jürgen, Strachan, David P., Waeber, Gérard, Bergman, Richard N., König, Inke R., Ingelsson, Erik, Workalemahu, Tsegaselassie, Lajunen, Taina, Kwan, Samantha, Nelson, James, Gloyn, Anna L., Clark, Lisa, Lehtimäki, Terho, Vitart, Veronique, Iribarren, Carlos, Stringham, Heather M., Chasman, Daniel I., Weedon, Michael N., Selph, Kimberly, Mc, Steven A., Contos, Melissa J., Farooqi, I. Sadaf, Erdmann, Jeanette, O'Rahilly, Stephen, Loos, Ruth J. F., Roberts, Sarah, Hall, Per, Rafelt, Suzanne, Hicks, Andrew A., Munroe, Patricia B., Dupuis, Josée, Mägi, Reedik, Quertermous, Thomas, Gaget, Stefan, Gyllensten, Ulf, Dehghan, Abbas, Manunta, Paolo, Perola, Markus, Wallaschofski, Henri, Heard-Costa, Nancy L., Ruokonen, Aimo, Sargeant, Carol, Molleston, Jean, King, Debra, Polasek, Ozren, Koskinen, Seppo, Ziegler, Andreas, Dixon, Anna L., van Duijn, Cornelia M., Bass, Nathan M., Smith, Melissa, Klipsch, Ann, Raitakari, Olli, Randall, Joshua, Zhang, Qunyuan, Wilson, James F., Wiegand, Susanna, Bhimalli, Prajakta, Robertson, Neil R., Schlessinger, David, Illig, Thomas, Hoesel, Volker, Rogers, Nicholette, Ruth Sargent, P. A. -C., Myers, Richard H., Laakso, Markku, Hayes, Richard B., Knowles, Joshua W., Buchanan, Thomas A., Visscher, Peter M., Lamina, Claudia, Chen, Chih-Mei, Ngwa, Julius S., Wheeler, Eleanor, Lanzani, Chiara, Duan, Jubao, Purcell, Shaun, Luan, Jian'an, Edwards, Kevin, Elosua, Roberto, Caulfield, Mark J., Kleiner, David, Jeffrey Carr, J., Ebrahim, Shah, Greenawalt, Danielle M., Sandhu, Manjinder S., Guiducci, Candace, Yeh, Matthew, Smit, Jan H., Bragi Walters, G., MAGIC Investigators, ,, Hall, Alistair S., Berndt, Sonja I., Kvaløy, Kirsti, Campbell, Harry, Narisu, Narisu, Folsom, Aaron R., Rayner, Nigel W., Schwimmer, Jeffrey B., Watanabe, Richard M., Allen, Hana Lango, Graham, Martin, Day, Ian N. M., Hu, Frank B., Atwood, Larry D., Mooney, Jody, Mulic, Rosanda, Groop, Leif C., Tammesoo, Mari-Liis, Brancati, Fred, Chanock, Stephen J., Franklin, Christopher S, Jacobs, Kevin B., Colvin, Ryan, Grönberg, Henrik, Peltonen, Leena, Widen, Elisabeth, Boehnke, Michael, Thomson, Brian, Brunt, Elizabeth, Johansson, Åsa, Green, Mika, Preuss, Michael, Witte, Daniel R., Steinthorsdottir, Valgerdur, Pichler, Irene, Silander, Kaisa, Xu, Jianfeng, Zitting, Paavo, Spector, Timothy D., Egan, Josephine M, Wilson, Laura, Khaw, Kay-Tee, Lecoeur, Cecile, Platou, Carl G. P., Stefansson, Kari, Cappuccio, Francesco P., Boomsma, Dorret I., Marek, Diana, Kovacs, Peter, Tönjes, Anke, Chatterjee, Nilanjan, Jones, Amy, Rissanen, Aila, Kraft, Peter, Stager, Margaret, Soranzo, Nicole, Hayward, Caroline, Schwarz, Peter, Igl, Wilmar, Filipowski, Danuta, Gustafsson, Stefan, Gieger, Christian, Viikari, Jorma, Hinney, Anke, NASH CRN, ,, Van Natta, Mark, Barlow, Sarah, Tyrer, Jonathan P., Hottenga, Jouke Jan, Kuusisto, Johanna, Thorleifsson, Gudmar, Neville, Matt J., Watkins, Hugh, Arnold, Alice M., Paré, Guillaume, Scott, Laura J., Oostra, Ben, Pellikka, Niina, Aspelund, Thor, van Meurs, Joyce B. J., Gottfried, Marcia, Boes, Tanja, Song, Kijoung, Petcharaporn, Lita, Schunkert, Heribert, Kathiresan, Sekar, Jula, Antti, Froguel, Philippe, Belt, Patricia, Wild, Sarah H., Lavine, Joel E., Uitterlinden, André G., Jansson, John-Olov, Sanyal, Arun J., Ripatti, Samuli, Connell, John, Yates, Katherine, Ridker, Paul M., Tuomilehto, Jaakko, Ouwehand, Willem H., Jewell, Elizabeth, Lantieri, Olivier, McKnight, Barbara, Pedersen, Oluf, Goddard, Michael E., Amin, Najaf, Linda Kao, W. H., Kettunen, Johannes, Rosenthal, Philip, Jackson, Anne U., Elliott, Paul, Vogel, Carla I. G., Isaacson, Milana, den Heijer, Martin, Hoofnagle, Jay H., Lanzani C, Boerwinkle, Eric, Wabitsch, Martin, Heinrich, Joachim, Vedantam, Sailaja, Perry, John R. B., Fischer-Posovszky, Pamela, Stewart, Susan, Rzehak, Peter, Wood, Andrew R., Lettre, Guillaume, Friedrich, Nele, Hartikainen, Anna-Liisa, Lee, Lydia, Surakka, Ida, Goel, Anuj, Erdos, Michael R., Shi, Jianxin, Behling, Cynthia, Havulinna, Aki S., Freimer, Nelson B., Hebebrand, Johannes, ?, ?, Zhao, Jing Hua, Yang, Jian, Winkler, Thomas W., Kaplan, Lee M., Kiemeney, Lambertus A., Kajantie, Eero, Donithan, Michele, Uda, Manuela, Isomaa, Bo, Prokopenko, Inga, Parker, Alex N., Bergmann, Sven, Groves, Christopher J., Lawlor, Debbie A., Cavalcanti-Proença, Christine, Steel, Tessa, Sparsø, Thomas, Bringman, Diane, Henneman, Peter, Visvikis-Siest, Sophie, Liu, Yao-Chang, Thompson, John R., Savolainen, Markku J., Ridderstråle, Martin, McArdle, Wendy L., Scherag, Susann, McCullough, Arthur, Pan, Yi-Ping, Grarup, Niels, Aben, Katja K., Adrienne Cupples, L., Chen, Yii-Der Ida, Ferreira, Teresa, Busonero, Fabio, Miriel, Laura, Park, Ju-Hyun, Stead, Alice, Haritunians, Talin, Bryan, Daphne, Penninx, Brenda W., Wright, Alan F., Thiering, Elisabeth, Tardif, Jean-Claude, Morris, Andrew P., Coin, Lachlan J. M., Ong, Ken K., Fuchs, Michael, Sinisalo, Juha, Homuth, Georg, Deloukas, Panos, Jarick, Ivonne, Wiklund, Fredrik, Wareham, Nicholas J., Laitinen, Jaana, Hawkins, Carol, Brown, Morris J., Stumvoll, Michael, Karpe, Fredrik, Timpson, Nicholas J., Pietiläinen, Kirsi H., Hofman, Albert, Durelle, Janis, Glazer, Nicole L., Meitinger, Thomas, Li, Shengxu, Neuschwander-Tetri, Brent A., Luben, Robert N., Bornstein, Stefan R., Moffatt, Miriam F., Vuppalanchi, Raj, Krude, Heiko, Robuck, Patricia R., McCarthy, Anne, Sandhu, Bimalijit, Wichmann, H. -Erich, Sternberg, Alice, Stein, Tanya, Guy, Cynthia, Hassanein, Tarek, Bambha, Kiran, Doney, Alex, Hveem, Kristian, Mohlke, Karen L., Midthjell, Kristian, Heid, Iris M., Lindgren, Cecilia M., Kutalik, Zoltán, Hattersley, Andrew T., Abdelmalek, Manal, Sirlin, Claude, Kaakinen, Marika, Martin, Nicholas G., Samani, Nilesh J., Bouatia-Naji, Nabila, Alavere, Helene, Langenberg, Claudia, Barroso, Inês, Siegner, Joan, Eriksson, Johan G., Doo, Edward, Carola Zillikens, M., Geus, Eco J. C., North, Kari E., Biebermann, Heike, Teder-Laving, Maris, Ragozzino, Linda, Swift, Amy, Pouta, Anneli, Lorentzon, Mattias, Sanders, Alan R., Schreiber, Stefan, Rivadeneira, Fernando, Derdoy, Jose, Grallert, Harald, Willemsen, Gonneke, Saramies, Jouko, Vatin, Vincent, Fu, Mao, Clarke, Robert, Rosenthal, Monique, Luketic, Velimir A. C., Mangino, Massimo, Tonascia, James, Barlassina, Christina, Ünalp, Aynur, Thorsteinsdottir, Unnur, Willer, Cristen J., Macciardi, Fabio, Hassanali, Neelam, Cummings, Oscar W., Stephens, Jonathan, Chines, Peter, John, Ulrich, Meyre, David, McCarthy, Mark I., Saxena, Richa, Hunter, David J., Marre, Michel, Merriman, Raphael, Navarro, Pau; id_orcid, Boeing, Heiner, O'DONNELL CJ, Jousilahti, Pekka, Kowdley, Kris V., Fisher, Eva, Rudan, Igor, Felix, Stephan B., Sandholt, Camilla, Reinehr, Thomas, Beckmann, Jacques S., Smith, George Davey, Morken, Mario A., van Ommen, Gert-Jan, Nelis, Mari, Ben-Shlomo, Yoav, White, Charles C., Alibrandi, Maria T. S., Everhart, Jay, Esko, Tõnu, Cooper, Matthew N., Absher, Devin M., Estrada, Karol, Johnson, Toby, Rief, Winfried, Gjesing, Anette P., GIANT Consortium, ,, MANUNTA P, Saunders, Cheryl, Scherag, Andre, Bennett, Amanda J., Hoffmann, Joyce, Nemesh, James, Kim, Wana, Heath, Andrew C., van Wingerden, Sophie, Blakemore, Alexandra I. F., Hui, Jennie, Pabst, Mark, Gold Consortium, ,, Montgomery, Grant W., Goyette, Philippe, Ferrell, Linda D., Levinson, Douglas F., Thompson, Judy, Bonnycastle, Lori L., Balkau, Beverley, Melander, Olle, Liang, Liming, Kolcic, Ivana, Segrè, Ayellet V., Seeff, Leonard, Kinnunen, Leena, Rybin, Denis, Nieminen, Markku S., Hansen, Torben, Sovio, Ulla, Witteman, Jacqueline C., Waite, Lindsay L., Nyholt, Dale R., Beilby, John P., Schipf, Sabine, Peters, Marjolein J., James, Alan L., O'Connell, Jeffrey R., Weyant, Robert J., Boyett, Sherry, Pramstaller, Peter P., Ohlsson, Claes, Kähönen, Mika, Tuomi, Tiinamaija, Metspalu, Andres   +803 more
core   +5 more sources

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma. [PDF]

PLoS ONE, 2015
BACKGROUND:Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, and genetic factors contribute ...
Amber Dahlin, Augusto Litonjua, John J Lima, Mayumi Tamari, Michiaki Kubo, Charles G Irvin, Stephen P Peters, Kelan G Tantisira   +7 more
doaj   +1 more source

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies [PDF]

, 2012
<p>Background - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less.
Furie, K., Benn, M. (Marianne), Carty, C., Reiner, AP, Palmer, Colin N.A., Markus, Hugh S, Lindgren, Arne,, Fornage, Myriam, Algra, Ale, Nalls, Mike A, de Bakker, P.I.W., Rothwell, Peter M., Worrall, Bradford B, Nalls, Mike A., Kuhlenbaeumer, Gregor, Deary, Ian, Levi, C., Palmer, Colin N. A., Delavaran, Hossein,, Berger, K., Reiner, A.P., Sharma, P, The Australian Stroke Genetics Collaborative, including Jonathan Golledge, Higgins, P., Palmer, CN, Worrall, BB, Vicente, A.M. (Astrid M), Helgadottir, A, Thorleifsson, G. (Gudmar), Rothwell, Peter M, Kuhlenbäumer, G., Pandolfo, M, Khan, M.I. (Muhammad), Khan, M.S., Stefansson, K, Wiggins, Kerri L., Lindgren, Arne, Vicente, Astrid M., Hofman, A., Bis, JC, Kittner, Steven J., Kittner, Steven, Boncoraglio, G. (Giorgio Battista), Schmidt, Reinhold, Palmer, C.N.A. (Colin), Nordestgaard, Børge G., Paré, Guillaume, Wiggins, K.L. (Kerri), Delavaran, H, de Bakker, Paul I. W., Cheng, Y.-C. (Yu-Ching), Sale, P. (Patrizio), Cheng, YC, Wiggins, K.L., Meschia, JF, Pandolfo, M. (Massimo), Levi, C, Sudlow, C. (Cathie), Saleheen, D, ?, ?, Ringelstein, E.B., Fomage, Myriam, Bevan, S, Wiggins, KL, Gretarsdottir, S. (Solveig), Zwart, J-A. (John-Anker), Nordestgaard, B.G., Deary, I.J. (Ian), Kuhlenbäumer, G, Mosley, Thomas H, Paré, G., Nalls, M.A., Algra, A. (Ale), Hopewell, Jemma C., Oliveira, SA, Berger, K. (Klaus), Traylor, M, Seshadri, S., Boncoraglio, G.B., Valdimarsson, Einar, Wiggins, Kerri L, van Zuydam, Natalie R., Lemmens, Robin, Carty, Cara, Worrall, B.B. (Bradford B.), Fernandez-Cadenas, I. (Israel), Benn, M, Achterberg, Sefanja, Vicente, Astrid M, Thijs, V, Ikram, M Arfan, Doney, AS, Dichgans, M, Zuydam, N.R. van, Wellcome Trust Case Control Consortium 2 (WTCCC2), Norrving, Bo,, Bakker, P.I.W. (Paul) de, Furie, K.L. (Karen), Nalls, M.A. (Michael), Yadav, S, Fernandez-Cadenas, I., Longstreth, W.T., Paré, G. (Guillaume), Mitchell, BD, Bakker, P.I.W. de, Norrving, B., Holliday, Elizabeth G., van Zuydam, N.R., Achterberg, S, van Zuydam, N.R,, Traylor, Mathew, Reiner, Alex P, Sharma, Pankaj, Montaner, J., Rothwell, PM, Kee, Weang, O'Donnell, M., Carty, C. (Cara), Cheng, Yu-Ching, Carty, C, Lund University., Rothwell, P.M. (Peter), Pandolfo, Massimo, Schmidt, Helena, Int Stroke Genetics Consortium, Norrving, Bo, de Bakker, Paul I W, Davies, Gail, Chen, W-M., Gretarsdottir, S., Gschwendtner, A., Bevan, Steve, Cheng, Y.-C., Abboud, S, Sharma, P. (Pankaj), Doney, Alexander S.F.; id_orcid, Norrving, B. (Bo), Benn, M., Ferro, Jose M., Slowik, A, Walters, Matthew, Yadav, S. (Sunaina), Delavaran, H. (Hossein), Holliday, E.G., Lindgren, A. (Arne), Meschia, James F, Farrall, M. (Martin), Pera, J, Longstreth, W. T., Oliveira, Sofia A., Helgadottir, H.T. (Hafdis), Ferro, Jose M, Reiner, Alex P., Slowik, A., Ringelstein, E.Bernd, Thorsteinsdottir, U, International Stroke Genetics Consortium, Sudlow, C., Longstreth, W, Chen, W.M., Malik, R. (Rainer), Mosley, Thomas H., Markus, H.S., Thorsteinsdottir, U. (Unnur), Abboud, S., Psaty, B.M. (Bruce), Mosley, T.H., Thijs, Vincent, Ikram, Arfan, Saleheen, D., Walters, M.R. (Matthew), Traylor, M., de Bakker, P.I., Montaner, J, O'Donnell, M, Oliveira, Sofia A, Ho, W.K., Kostulas, Konstantinos, Hofman, Albert, Palmer, CNA, Levi, C. (Christopher), Chen, W.-M., Higgins, P, Bevan, S., Longstreth Jr, W.T., Doney, A.S., Mitchell, B.D. (Braxton), Seshadri, S. (Sudha), Sale, M, Ho, WK, Furie, Karen, Delavaran, H., Sale, M., Valdimarsson, E, Cheng, Y.C., Slowik, A. (Agnieszka), DeStefano, A.L. (Anita), Rosand, J. (Jonathan), Davies, G. (Gail), Helgadottir, Anna, Psaty, Bruce M., O'Donnell, M. (Martin), Australian Stroke Genetics Collaborative, Wellcome Trust Case Co, Mitchell, Braxton D., Walters, M., Doney, ASF, van Zuydam, Natalie R, de Bakker, PIW, Rosand, Jonathan, Holliday, Elizabeth G, Fernandez-Cadenas, I, Bis, Joshua C, Delavaran, Hossein, Bevan, S. (Steve), Achterberg, S. (Sefanja), Valdimarsson, E. (Einar), Lemmens, R, Bis, J.C. (Joshua), Benn, Marianne, Parati, E.A., Kubisch, C. (Christian), Gschwendtner, A. (Andreas), Hofman, Bert, Farrall, M, Montaner, J. (Joan), Meschia, J.F. (James F.), Khan, Muhammad Saleem, Kittner, Steven J, Levi, Christopher, Sudlow, Catherine; id_orcid, Davies, G, Palmer, C.N.A., Oliveira, S.A. (Sofia), Psaty, Bruce M, Rothwell, P.M., Pera, M.F. (Martin ), Parati, E.A. (Eugenio), Oliveira, S.A., Furie, K, Dichgans, M., van Zuydam, NR, Boncoraglio, Giorgio B, Kittner, S, Berger, Klaus, Pera, Joanna, Davies, G., Higgins, P. (Peter), Pandolfo, M., Holliday, EG, Valdimarsson, E., Rosand, J., Palmer, Colin N A, Ho, Weang Kee, Deary, I., Bis, J.C., Lemmens, R., Clarke, Robert, Boncoraglio, Giorgio B., Sudlow, C, Kuhlenbäumer, G. (Gregor), Schmidt, H., Abboud, Sherine, Ferro, M.T. (María), Australian Stroke Genetics Collabo, Higgins, Peter, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Lindgren, A, Clarke, R., Thorsteinsdottir, Unnur, Fornage, M., Mosley, TH, Ringelstein, E Bernd, Parati, Eugenio A, DeStefano, A.L., Lemmens, R. (Robin), Stefansson, K., Markus, HS, Chen, Wei-Min, Doney, Alexander S. F., Ringelstein, EB, Bis, Joshua C., Ikram, M.A., Rosand, J, Ferro, J. M., Norrving, B, Farrall, M., Seshadri, S, International Stroke Genetics Consortium., Walters, Mathew, Kostulas, K. (Konstantinos), Thorleifsson, G, Doney, Alexander S.F., Malik, R, Destefano, AL, Slowik, Agnieszka, Thijs, V. (Vincent), Lindgren, A., Longstreth, Wt, Nordestgaard, B.G. (Børge), Clarke, R. (Robert), Stefansson, Kan, Kostulas, K., Destefano, Anita L, Schmidt, R, Fomage, M., Farrall, Martin, Ferro, J.M., Schmidt, R. (Reinhold), Schmidt, H, WTCCC 2, Palmer, Colin N.A.; id_orcid, Helgadottir, A., Fernandez-Cadenas, Israel, Stefansson, Kari, Nordestgaard, BG, Ikram, M. Arfan, Sharma, P., Abboud, S. (Shimon), Clarke, R, Parati, EA, Gretarsdottir, Solveig, Berger, K, Hofman, A. (Albert), Palmer, C.N., Kittner, S., Algra, A, Fornage, M. (Myriam), Ringelstein, E.B. (E. Bernd), Nalls, MA, Fornage, M, O'Donnell, Martin, Longstreth, W., Kittner, T. (Thomas), Algra, A., Thorsteinsdottir, U., Kittner, S.J., Sale, Michele, Fomage, M, Reiner, A. (Alexander), Kittner, SJ, Ikram, MA, Deary, I, Worrall, B.B., Ferro, JM, Gschwendtner, Andreas, Dichgans, Martin, Holliday, E.G. (Elizabeth), Thorleifsson, G., Gschwendtner, A, Schmidt, R., de Bakker, Paul I.W., Nordestgaard, Børge G, Traylor, M. (Matthew), Mosley, T.H. (Thomas), DeStefano, Anita L., Doney, A.S.F. (Alex), Nordestgaard, Borge G., Thorleifsson, Gudmar, Yadav, S., Kostulas, K, Vicente, A.M., Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Psaty, BM, de Bakker, PI, Parati, Eugenio A., Saleheen, Danish, Khan, MS, Vicente, AM, Walters, M, Psaty, B.M., Hofman, A, Hopewell, Jemma C, Meschia, J.F., Pera, J., Doney, A.S.F., Mitchell, B.D., Markus, Hugh S., Kuhlenbäumer, Gregor, Hopewell, JC, Zuydam, N.R. (Natalie) van, Chen, WM, Thijs, V., Gretarsdottir, S, Yadav, Sunaina, Markus, H.S. (Hugh), Hopewell, J., Ringelstein, E. Bernd, Sudlow, Cathie, Paré, G, Montaner, Joan, Ho, W.K. (Weang Kee), Achterberg, S., Doney, Alexander S F, Seshadri, Sudha, Hopewell, J.C., Meschia, James F., Ikram, M.A. (Arfan), Malik, Rainer, Hopewell, Jemma, Traylor, Matthew, Cheng, Y-C   +403 more
core   +2 more sources

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies

Arthritis Research & Therapy, 2019
Background Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.
Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang, Feng Zhang   +9 more
doaj   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
core  

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis [PDF]

, 2013
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These
Vermeire, S, Richard H. Duerr (107855), Steve R. Brant, Barclay, M, Sharma, Y., Alikashani, Azadeh, Rutgeerts, P, Colombel, JF, Philippe Goyette, Franke, Andre,, Gautam Goel (457889), Sharma, Yashoda,, Targan, SR, Bresso, Francesca,, Lawrance, I, Ken Sin Lo (457887), Xavier, Ramnik, Jonas Halfvarson, Levine, A, International IBD Genetics Consortium, [missing], McGovern, Dermot P. B., Lo, KS, Regueiro, M, Ellinghaus, David, Stevens, Christine,, International IBD Genetics Consortium, Ahmad, T, D'Inca, R, Bitton, A., Ramnik J. Xavier (153776), Sharma, Y, Lo, K.S., International, I.B.D.G.C., Judy H Cho, Silverberg, MS, Franke, A., Beaudoin, Melissa,, Goel, G, Griffiths, AM, Törkvist, L, Quebec IBD Genetics Consortium, [missing], Azadeh Alikashani (457888), Caroline Lagacé, Weersma, Rinse K., D'Amato, M., Glas, J, Sharma, Yashoda, Weersma, Rinse K.,, Philip L Schumm, Lettre, G., Mowat, Craig; id_orcid, Panés, J, Gautam Goel, Ellinghaus, D., Stevens, C., Beaudoin, Melissa, Jostins, L, Vermeire, S., Guthery, SL, Annese, V, Bis, JC, Lettre, Guillaume, Mélissa Beaudoin, Radford-Smith, G., Azadeh Alikashani, Duerr, RH, Lagacé, C, Boucher, Gabrielle,, Radford-Smith, GL, Newman, W, Florin, T, Phillips, A, Philip L. Schumm (457892), Guillaume Lettre (163230), Weersma, R.K., Gearry, R, Goyette, P., van Gossum, A, Rioux, J.D., Silverberg, Mark S., Lee, J, Vermeire, Severine, Franchimont, Denis, Yashoda Sharma, Mark S Silverberg, Goel, Gautam,, Mauro D'Amato (191109), Daly, Mark J.,, Georges, M, Latiano, A, Duerr, R.H., Proctor, DD, Quebec IBD Genetics Consortium, Duerr, Richard H., Begun, Jakob,, Schreiber, Stefan, John D Rioux, Stevens, Christine, Bresso, F, Cho, Judy H., Schreiber, S., Leif Törkvist (191104), Rivas, M. A., Severine Vermeire, McGovern, D.P.B., Weersma, Rinse K.; id_orcid, Ladouceur, Martin,, Mitrovic, M, Halfvarson, J., Laukens, D, Brant, Steve R., Halfvarson, J, Halfvarson, Jonas, David Ellinghaus (87596), ?, ?, Yashoda Sharma (362205), , K.S. lo, Parkes, M, Mark J Daly, Vito Annese (212128), Lo, Ken Sin,, Rioux, JD, Guillaume Lettre, Manuel A. Rivas, Philip L. Schumm, Goyette, P, Silverberg, M.S., et al., Schumm, PL, Bitton, Alain, Goel, G., Brand, S, Xavier, Ramnik J.,, Christine Stevens (401796), John D. Rioux, Aumais, G, Martin Ladouceur (144366), Cohen, A, Van Gossum, André, Rivas, M.A., Cho, JH, Rivas, Manuel A.,, Cottone, M, Steve R Brant, Ramnik J Xavier, Schumm, Philip L.,, Ken Sin Lo, Cho, Judy H.,, Palmieri, O, Jakob Begun, Gabrielle Boucher, Xavier, R.J., Christine Stevens, Lettre, G, Halfvarson, Jonas,, Brant, S.R., McGovern, Dermot P. B.,, Daly, Mark J., Manuel A Rivas, Potocnik, U, Stevens, C, Begun, J., Philippe Goyette (215465), Ladouceur, M, Bitton, Alain,, Silverberg, Mark S.,, Dermot P B McGovern, McGovern, DPB, Lo, Ken Sin, Alain Bitton (259250), Balschun, T, Prescott, NJ, Boucher, Gabrielle, Anderson, CA, Bresso, F., Schreiber, S, Annese, Vito,, Lo, K. S., International IBD Genetics Consortium,, Schreiber, Stefan,, Francesca Bresso, Mark S. Silverberg, Montgomery, GW, Ladouceur, M., Lees, CW, David Ellinghaus, Mansfield, JC, Mathew, CG, Judy H. Cho, Kugathasan, S, Caroline Lagacé (215515), Franke, Andre, Satsangi, Jack, Weersma, RK, Bresso, Francesca, Mauro D'Amato, Ellinghaus, D, John D. Rioux (215621), McGovern, D.P., Lagace, C., D'Amato, Mauro, Lemann, M, Franke, A, Gabrielle Boucher (215508), Alikashani, Azadeh,, Begun, Jakob, Graham Radford-Smith, Lettre, Guillaume,, Leif Törkvist, Alain Bitton, Mark J. Daly, Deslandres, C, Mowat, C, Steinhart, AH, NIDDK IBD Genetics Consortium, [missing], Xavier, RJ, Boucher, G, Libioulle, C, Lees, Charlie, Rinse K. Weersma (131692), Richard H Duerr, Schumm, P.L., Ellinghaus, David,, Judy H. Cho (159806), Goel, Gautam, Martin Ladouceur, Kullak-Ublick, G, Törkvist, Leif,, Vito Annese, Lagace, Caroline,, D'Amato, Mauro,, Jakob Begun (273749), Begun, J, Alikashani, A., Annese, Vito, Brant, Steve R.,, Int IBD Genetics Consortium, Ponsioen, CY, Ladouceur, Martin, Graham Radford-Smith (457891), Radford-Smith, Graham L., Duerr, Richard H.,, Daly, M.J., Beaudoin, M., Goyette, Philippe, Torkvist, L., Lahaie, R, Dermot P. B. McGovern (179863), Rivas, Manuel A., Brant, SR, Edwards, C, Bayless, TM, Hakonarson, H, Ramnik J. Xavier, Gibson, Greg, Stefan Schreiber, Radford-Smith, Graham,, Louis, E, Mark S. Silverberg (179888), Annese, V., Beaudoin, M, Bernard, EJ, de Jong, DJ, Rivas, MA, Buning, C, Jong, D.J. de, Manuel A. Rivas (228371), Dermot P. B. McGovern, Haritunians, T, Goyette, Philippe,, Consortium, N.I.G., Rinse K. Weersma, Cho, J.H., Baldassano, RN, Mark J. Daly (210204), Andre Franke (77511), Lagace, Caroline, Denson, T, Franchimont, D, Mélissa Beaudoin (457886), NIDDK IBD Genetics Consortium, Alikashani, A, Boucher, G., D'Amato, M, Hugot, JP, Bitton, A, Severine Vermeire (5649814), Schumm, Philip L., Barrett, JC, Richard H. Duerr, Quebec, I.B.D.G.C., Rioux, John D., Steve R. Brant (457890), Andre Franke, Dubinsky, M, Stefan Schreiber (36915), Laukens, Debby, Daly, MJ, Bumpstead, S, Francesca Bresso (191101), Rinse K Weersma, Xavier, Ramnik J., Daly, Mark, Torkvist, Leif, Jonas Halfvarson (117749), Radford-Smith, Graham, Paré, P, Rioux, John D.,, Vermeire, Severine,   +308 more
core   +3 more sources

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source