Results 71 to 80 of about 22,244,058 (261)

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

open access: yesAdvanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu   +15 more
wiley   +1 more source

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium [PDF]

open access: yes, 2011
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease.
Marsit CJ   +934 more
core   +2 more sources

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

open access: yesAdvanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English   +9 more
wiley   +1 more source

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function [PDF]

open access: yes, 2011
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 ...
Stricker, Bruno H. Ch   +902 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

open access: yesAdvanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin   +18 more
wiley   +1 more source

Application of GWAS and mGWAS in Livestock and Poultry Breeding

open access: yesAnimals
In recent years, genome-wide association studies (GWAS) and metabolome genome-wide association studies (mGWAS) have emerged as crucial methods for investigating complex traits in animals and plants.
Jing Ren   +9 more
doaj   +1 more source

Evaluation of association of HNF1B variants with diverse cancers : collaborative analysis of data from 19 genome-wide association studies [PDF]

open access: yes, 2010
Background Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk.
Tomlinson, IP   +280 more
core   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

open access: yesAdvanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou   +4 more
wiley   +1 more source

Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease

open access: yesHuman Genomics, 2018
Background Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD).
Jarrett D. Morrow   +14 more
doaj   +1 more source

Genome-wide screening for DNA variants associated with reading and language traits. [PDF]

open access: yes, 2014
Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis ...
J. F. Stein   +129 more
core   +1 more source

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