Results 71 to 80 of about 189,144 (345)

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Gene Discovery and Data Sharing in Genome Wide Association Analyses: Lessons Form AIDS Genetic Restriction Genes [PDF]

, 2014
As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative ...
Cherkasov, Nikolay, Dobrynin, Pavel, Geerts, Paul, Hendrickson, Sher L., Hutcheson, Holli, Malov, Sergey, O\u27Brien, Stephen J., Sezgin, Efe, Svitin, Anton, Troyer, Jennifer L.   +9 more
core   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Application of GWAS and mGWAS in Livestock and Poultry Breeding

Animals
In recent years, genome-wide association studies (GWAS) and metabolome genome-wide association studies (mGWAS) have emerged as crucial methods for investigating complex traits in animals and plants.
Jing Ren, Zhendong Gao, Ying Lu, Mengfei Li, Jieyun Hong, Jiao Wu, Dongwang Wu, Weidong Deng, Dongmei Xi, Yuqing Chong   +9 more
doaj   +1 more source

Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease

Human Genomics, 2018
Background Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD).
Jarrett D. Morrow, Michael H. Cho, John Platig, Xiaobo Zhou, Dawn L. DeMeo, Weiliang Qiu, Bartholome Celli, Nathaniel Marchetti, Gerard J. Criner, Raphael Bueno, George R. Washko, Kimberly Glass, John Quackenbush, Edwin K. Silverman, Craig P. Hersh   +14 more
doaj   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

GRIMP: A web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data. [PDF]

, 2009
The current fast growth of genome-wide association studies (GWAS) combined with now common computationally expensive imputation requires the online access of large user groups to high-performance computing resources capable of analyzing rapidly and ...
Altshuler, André G. Uitterlinden, Anis Abuseiris, Aulchenko, de Bakker, de Zeeuw, Fernando Rivadeneira, Frank G. Grosveld, Hofman, International HapMap Consortium, Karol Estrada, Krefting, Li, Marchini, Psaty, Tobias A. Knoch   +15 more
core   +3 more sources

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

SAERMA: Stacked Autoencoder Rule Mining Algorithm for the Interpretation of Epistatic Interactions in GWAS for Extreme Obesity

IEEE Access, 2020
One of the most important challenges in the analysis of high-throughput genetic data is the development of efficient computational methods to identify statistically significant Single Nucleotide Polymorphisms (SNPs). Genome-wide association studies (GWAS)
Casimiro A. Curbelo Montanez, Paul Fergus, Carl Chalmers, Nurul Hashimah Ahamed Hassain Malim, Basma Abdulaimma, Denis Reilly, Francesco Falciani   +6 more
doaj   +1 more source

A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population [PDF]

, 2013
Plasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been ...
Chang, Jiang, Chen, Weihong, Dai, Xiayun, Deng, Qifei, Fang, Weimin, Gao, Yong, Guo, Huan, He, Meian, He, Yunfeng, Hu, Frank B., Huang, Suli, Lang, Mingjian, Li, Dongfeng, Li, Huaixing, Liang, Yuan, Lilly Zheng, S., Lin, Dafeng, Lin, Dongxin, Lin, Xu, Miao, Xiaoping, Min, Xinwen, Mo, Zengnan, Qin, Xue, Sun, Jielin, Tan, Aihua, Tan, Wen, Wang, Feng, Wang, Yiqin, Wang, Youjie, Wei, Sheng, Wu, Chen, Wu, Tangchun, Xu, Jianfeng, Yang, Handong, Yang, Xiaobo, Yu, Dianke, Yuan, Jing, Zhai, Kan, Zhang, Haiying, Zhang, Xiaomin, Zhou, Li, Zhu, Jiang, Zhu, Jingwen   +42 more
core   +3 more sources