Results 131 to 140 of about 1,111,517 (383)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases

, 2023
Mattia Tomasoni, Michael J. Beyeler, Sofía Ortín Vela, Ninon Mounier, Eleonora Porcu, Tanguy Corre, Daniel Krefl, Alexander L. Button, Hana Abouzeid, Lazaros Konstantinidis, Murielle Bochud, Reinier O. Schlingemann, Ciara Bergin, Sven Bergmann   +13 more
openalex   +1 more source

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses [PDF]

, 2023
Benjamin G Faber, Monika Frysz, Cindy G. Boer, Daniel S. Evans, Raja Ebsim, Kaitlyn Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R. Saunders, Claudia Lindner, J.S. Gregory, R.M. Aspden, Nancy E. Lane, Nicholas C. Harvey, David M. Evans, Eleftheria Zeggini, George Davey Smith, T.F. Cootes, Joyce B. J. van Meurs, John P. Kemp, Jonathan H. Tobias   +21 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterization of Insect Resistance Loci in the USDA Soybean Germplasm Collection Using Genome-Wide Association Studies

Frontiers in Plant Science, 2017
Management of insects that cause economic damage to yields of soybean mainly rely on insecticide applications. Sources of resistance in soybean plant introductions (PIs) to different insect pests have been reported, and some of these sources, like for ...
Hao-Xun Chang, Glen L. Hartman
doaj   +1 more source

Genome‐wide association studies of response and side effects to the BNT162b2 vaccine in Italian healthcare workers: Increased antibody levels and side effects in carriers of the HLA‐A*03:01 allele [PDF]

, 2023
Chiara Magri, Eleonora Marchina, Emanuele Sansone, Pio D’Adamo, Stefania Cappellani, Carlo Bonfanti, Luigina Terlenghi, Giorgio Biasiotto, Isabella Zanella, Emma Sala, Arnaldo Caruso, Massimo Lombardo, Paolo Gasparini, Giuseppe De Palma, Massimo Gennarelli   +14 more
openalex   +1 more source

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

bioRxiv, 2019
Rationale Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium.
R. Allen, B. Guillen-Guio, J. Oldham, Shwu-Fan Ma, A. Dressen, Megan L. Paynton, L. M. Kraven, M. Obeidat, Xuan Li, M. Ng, R. Braybrooke, M. Molina-Molina, B. Hobbs, R. Putman, P. Sakornsakolpat, H. Booth, W. Fahy, S. Hart, M. Hill, N. Hirani, R. Hubbard, R. McAnulty, A. Millar, V. Navaratnam, E. Oballa, H. Parfrey, G. Saini, M. Whyte, Yingze Zhang, N. Kaminski, A. Adegunsoye, M. Strek, M. Neighbors, X. R. Sheng, G. Gudmundsson, V. Gudnason, H. Hatabu, D. Lederer, A. Manichaikul, J. Newell, G. O'Connor, V. Ortega, Hanfei Xu, T. Fingerlin, Y. Bossé, K. Hao, P. Joubert, D. Nickle, D. Sin, W. Timens, D. Furniss, A. Morris, K. Zondervan, I. Hall, I. Sayers, M. Tobin, T. Maher, M. Cho, G. Hunninghake, D. Schwartz, B. Yaspan, P. Molyneaux, C. Flores, I. Noth, R. Jenkins, L. Wain   +65 more
semanticscholar   +1 more source

Genome-wide association studies reach hepatology [PDF]

Journal of Hepatology, 2009
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, Hobbs HH. Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups.
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

TIMP4 as a Potential Complementary Biomarker and Therapeutic Target in Membranous Nephropathy: A Multi-Omics Investigation with Clinical Validation

Journal of Inflammation Research
Qingsong Chen, Gang Wang, Ruo Zhao, Qiyuan Hu, Jiayun Li, Yuting Wang, Jingyang Ran, Qi Huang, Guiquan Yu, Yanjia Luo, Xiaohui Liao Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...
Chen Q, Wang G, Zhao R, Hu Q, Li J, Wang Y, Ran J, Huang Q, Yu G, Luo Y, Liao X   +10 more
doaj