Results 131 to 140 of about 1,051,148 (367)

A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle

Frontiers in Genetics, 2019
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions and genetic variants associated with phenotypes. However, only limited mutual confirmation from different studies is available.
Jicai Jiang, Li Ma, Dzianis Prakapenka, P. Vanraden, J. Cole, Y. Da   +5 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

bioRxiv, 2019
Rationale Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium.
R. Allen, B. Guillen-Guio, J. Oldham, Shwu-Fan Ma, A. Dressen, Megan L. Paynton, L. M. Kraven, M. Obeidat, Xuan Li, M. Ng, R. Braybrooke, M. Molina-Molina, B. Hobbs, R. Putman, P. Sakornsakolpat, H. Booth, W. Fahy, S. Hart, M. Hill, N. Hirani, R. Hubbard, R. McAnulty, A. Millar, V. Navaratnam, E. Oballa, H. Parfrey, G. Saini, M. Whyte, Yingze Zhang, N. Kaminski, A. Adegunsoye, M. Strek, M. Neighbors, X. R. Sheng, G. Gudmundsson, V. Gudnason, H. Hatabu, D. Lederer, A. Manichaikul, J. Newell, G. O'Connor, V. Ortega, Hanfei Xu, T. Fingerlin, Y. Bossé, K. Hao, P. Joubert, D. Nickle, D. Sin, W. Timens, D. Furniss, A. Morris, K. Zondervan, I. Hall, I. Sayers, M. Tobin, T. Maher, M. Cho, G. Hunninghake, D. Schwartz, B. Yaspan, P. Molyneaux, C. Flores, I. Noth, R. Jenkins, L. Wain   +65 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. [PDF]

, 2009
Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data ...
Abraham, Clara, Achkar, Jean-Paul, Annese, Vito, Barmada, M Michael, Bayless, Theodore M, Bossa, Fabrizio, Brant, Steven R, Cho, Judy H, Daly, Mark J, Duerr, Richard H, Goyette, Philippe, Gregersen, Peter K, Griffiths, Anne M, Ippoliti, Andrew F, Kistner, Emily O, Klei, Lambertus, Lahaie, Raymond G, Latiano, Anna, Lee, Annette T, McGovern, Dermot PB, Paré, Pierre, Proctor, Deborah D, Regueiro, Miguel D, Rioux, John D, Roeder, Kathryn, Rotter, Jerome I, Schumm, L Philip, Scott, Regan, Silverberg, Mark S, Steinhart, A Hillary, Targan, Stephan R, Taylor, Kent D, Wu, Jing, Xu, Wei   +33 more
core  

Genome-wide Association Study of Peripheral Artery Disease in the Million Veteran Program

Nature Network Boston, 2019
Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality; however, the extent to which genetic factors increase risk for PAD is largely unknown.
D. Klarin, J. Lynch, Krishna G. Aragam, M. Chaffin, T. Assimes, Jie Huang, K. Lee, Q. Shao, J. Huffman, P. Natarajan, S. Arya, Aeron M. Small, Yan V. Sun, M. Vujković, M. Freiberg, Lu Wang, Jinbo Chen, D. Saleheen, Jennifer S. Lee, Donald R. Miller, P. Reaven, Patrick R. Alba, Olga V. Patterson, S. Duvall, W. Boden, J. Beckman, J. Gaziano, J. Concato, D. Rader, Kelly Cho, Kyong‐Mi Chang, P. Wilson, C. O’Donnell, S. Kathiresan, P. Tsao, S. Damrauer   +35 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

High-dimensional genome-wide association study and misspecified mixed model analysis

, 2014
We study behavior of the restricted maximum likelihood (REML) estimator under a misspecified linear mixed model (LMM) that has received much attention in recent gnome-wide association studies.
Jiang, Jiming, Li, Cong, Paul, Debashis, Yang, Can, Zhao, Hongyu   +4 more
core  

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Nature Communications, 2019
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study
P. Lyons, J. Peters, F. Alberici, J. Liley, R. Coulson, W. Astle, C. Baldini, F. Bonatti, M. Cid, H. Elding, G. Emmi, J. Epplen, L. Guillevin, D. Jayne, T. Jiang, I. Gunnarsson, P. Lamprecht, S. Leslie, M. Little, D. Martorana, F. Moosig, T. Neumann, S. Ohlsson, S. Quickert, G. Ramirez, B. Rewerska, G. Schett, R. Sinico, W. Szczeklik, V. Tesar, Damjan Vukcevic, B. Terrier, R. Watts, A. Vaglio, J. Holle, C. Wallace, Kenneth G. C. Smith   +36 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source