Results 141 to 150 of about 674,070 (352)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceGenome-wide association study identifies novel breast cancer susceptibility loci
Nature, 2007 Don M. Conroy, M. Shah, Hannah Munday, C. Jordan, B. Perkins, Judy West, Karen Redman, K. Driver, M. Aghmesheh, D. Amor, Lesley Andrews, Y. Antill, Jane Armes, Shane Armitage, Leanne Arnold, Rosemary L. Balleine, Glenn Begley, J. Beilby, Ian Bennett, Barbara Bennett, Geoffrey Berry, Anneke Blackburn, Meagan Brennan, Melissa Brown, Michael Buckley, J. Burke, P. Butow, Keith Byron, David F. Callen, Ian Campbell, G. Chenevix-Trench, Christine L. Clarke, Alison Colley, Dick Cotton, Jisheng Cui, Bronwyn Culling, Margaret Cummings, Sarah-Jane Dawson, Joanne Dixon, Alexander Dobrovic, Tracy Dudding, Ted Edkins, M. Eisenbruch, G. Farshid, Susan Fawcett, Michael Field, F. Firgaira, Jean Fleming, John F Forbes, M. Friedlander, Clara Gaff, Mac Gardner, M. Gattas, Peter George, G. Giles, G. Gill, Jack Goldblatt, Sian Greening, S. Grist, E. Haan, Marion Harris, Stewart Hart, N. Hayward, J. Hopper, Evelyn Humphrey, M. Jenkins, Alison Jones, R. Kefford, Judy Kirk, James Kollias, Sergey Kovalenko, Sunil R. Lakhani, Jennifer Leary, Jacqueline Lim, Geoff Lindeman, Lara Lipton, Lizz Lobb, Mariette Maclurcan, Graham J. Mann, Deb Marsh, M. Mccredie, Michael McKay, Sue-Anne McLachlan, B. Meiser, R. Milne, Gillian Mitchell, Beth Newman, Imelda O’Loughlin, Lester Peters, K. Phillips, Melanie Price, Jeanne Reeve, Tony Reeve, Gina Rinehart, Bridget Robinson, Elizabeth Salisbury, J. Sambrook, Christobel Saunders, C. Scott, Elizabeth Scott, Rodney J. Scott, Andrew N Shelling, M. Southey, A. Spurdle, Graeme Suthers, Donna Taylor, Christopher Tennant, Heather Thorne, S. Townshend, Kathy Tucker, Janet Tyler, D. Venter, J. Visvader, I. Walpole, Robin Ward, P. Waring, Bev Warner, Graham Warren, Elizabeth Watson, Rachael Williams, Judy Wilson, Ingrid Winship, Adele Green, D. Gertig, P. Webb +124 moresemanticscholar +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceGene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Nature Genetics, 2018 James J. Lee, Robbee Wedow, A. Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, J. Sidorenko, R. Karlsson Linnér, M. Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, P. Timshel, R. Walters, E. Willoughby, L. Yengo, Michelle Babak Adam Robert K. Katarzyna Sarah L. Pierre Dav Agee Alipanahi Auton Bell Bryc Elson Fontanillas H, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, D. Hinds, J. McCreight, K. Huber, N. Litterman, M. Mcintyre, Joanna L. Mountain, E. Noblin, C. Northover, S. Pitts, J. Sathirapongsasuti, O. V. Sazonova, J. Shelton, S. Shringarpure, C. Tian, V. Vacic, C. H. Wilson, Aysu Jonathan P. Mark Alan James J. Tune H. Cornelius A Okbay Beauchamp Fontana Lee Pers Rietveld Turley C, A. Okbay, J. Beauchamp, James J. Lee, T. Pers, C. A. Rietveld, P. Turley, Guo-Bo Chen, V. Emilsson, S. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, P. Timshel, R. Vlaming, A. Abdellaoui, T. Ahluwalia, J. Bacelis, C. Baumbach, G. Bjornsdottir, J. Brandsma, M. P. Concas, J. Derringer, N. Furlotte, T. Galesloot, G. Girotto, Richa Gupta, Leanne M. Hall, Sarah E. Harris, E. Hofer, M. Horikoshi, J. Huffman, Kadri Kaasik, I. Kalafati, R. Karlsson, Augustine Kong, J. Lahti, S. J. van der Lee, C. D. Leeuw, P. Lind, Karl-Oskar Lindgren, Tian Liu, M. Mangino, J. Marten, E. Mihailov, Michael B. Miller, P. J. van der Most, C. Oldmeadow, A. Payton, N. Pervjakova, W. Peyrot, Yong Qian, Olli T Raitakari, R. Rueedi, E. Salvi, Börge Schmidt, Katharina E. Schraut, Jianxin Shi, A. Smith, R. Poot, Beate St Pourcain, A. Teumer, G. Thorleifsson, N. Verweij, D. Vuckovic, J. Wellmann, H. Westra, Jingyun Yang, Wei Zhao, Zhihong Zhu, B. Alizadeh, N. Amin, A. Bakshi, S. Baumeister, G. Biino, K. Bønnelykke, P. Boyle, H. Campbell, Francesco P. Cappuccio, G. Davies, J. De Neve, P. Deloukas, I. Demuth, Jun Ding, P. Eibich, L. Eisele, N. Eklund, David M. Evans, J. Faul, M. Feitosa, A. Forstner, I. Gandin, Bjarni Gunnarsson, B. Halldórsson, T. Harris, A. Heath, L. Hocking, Elizabeth G. Holliday, G. Homuth, Michael A. Horan, J. Hottenga, P. D. De Jager, Peter K. Joshi, A. Jugessur, M. Kaakinen, M. Kähönen, S. Kanoni, Liisa Keltigangas-Järvinen, L. Kiemeney, I. Kolčić, S. Koskinen, A. Kraja, Martin Kroh, Z. Kutalik, A. Latvala, L. Launer, Maël P. Lebreton, D. Levinson, P. Lichtenstein, P. Lichtner, D. Liewald, LifeLines Cohort Study, Anu Loukola, P. Madden, R. Mägi, T. Mäki-Opas, R. Marioni, P. Marques-Vidal, Gerardus A. Meddens, George Mcmahon, Christa Meisinger, T. Meitinger, Y. Milaneschi, L. Milani, G. Montgomery, Ronny Myhre, Christopher P. Nelson, D. Nyholt, William E. R. Ollier, A. Palotie, L. Paternoster, N. Pedersen, Katja E. Petrovic, D. Porteous, K. Räikkönen, Susan M. Ring, A. Robino, Olga Rostapshova, I. Rudan, Aldo Rustichini, V. Salomaa, A. Sanders, Antti-Pekka Sarin, H. Schmidt, Rodney J Scott, Blair H. Smith, Jennifer A Smith, J. Staessen, Elisabeth Steinhagen-Thiessen, K. Strauch, A. Terracciano, Martin D. Tobin, Sheila Ulivi, S. Vaccargiu, L. Quaye, F. V. van Rooij, Cristina Venturini, Anna A. E. Vinkhuyzen, U. Völker, H. Völzke, J. Vonk, D. Vozzi, Johannes Waage, E. Ware, G. Willemsen, J. Attia, David A. Bennett, Klaus Berger, L. Bertram, H. Bisgaard, D. Boomsma, I. Borecki, Ute Bültmann, C. Chabris, F. Cucca, D. Cusi, I. Deary, G. Dedoussis, Cornelia M. van Duijn, J. Eriksson, Barbara Franke, L. Franke, Paolo Gasparini, P. Gejman, C. Gieger, Hans‐Jörgen Grabe, J. Gratten, Patrick J. F. Groenen, V. Gudnason, P. van der Harst, Caroline Hayward, Wolfgang Hoffmann, Elina Hyppönen, W. Iacono, B. Jacobsson, M. Järvelin, K. Jöckel, J. Kaprio, S. Kardia, T. Lehtimäki, Steven F. Lehrer, Patrik K. E. Magnusson, N. Martin, M. McGue, A. Metspalu, N. Pendleton, B. Penninx, M. Perola, N. Pirastu, Mario Pirastu, O. Polašek, D. Posthuma, Christine Power, M. A. Province, Nilesh J. Samani, D. Schlessinger, R. Schmidt, T. I. Sørensen, Timothy D. Spector, K. Stefansson, U. Thorsteinsdóttir, A. Thurik, N. Timpson, Henning Tiemeier, J. Tung, A. Uitterlinden, V. Vitart, P. Vollenweider, David R. Weir, James F. Wilson, Alan F. Wright, D. Conley, Robert F. Krueger, G. D. Smith, A. Hofman, David Laibson, S. Medland, M. Meyer, Jian Yang, M. Johannesson, P. Visscher, T. Esko, P. Koellinger, D. Cesarini, Daniel J. Benjamin, Maris Alver, Y. Bao, D. Clark, F. Day, Peter K. Joshi, K. Kemper, A. Kleinman, C. Langenberg, J. Trampush, S. Verma, Yang Wu, M. Lam, J. Zhao, Zhili Zheng, J. Boardman, J. Freese, K. Harris, Caroline Hayward, P. Herd, M. Kumari, T. Lencz, J. Luan, A. Malhotra, L. Milani, K. Ong, J. Perry, M. Ritchie, M. Smart, Blair H. Smith, N. Wareham, James F. Wilson, J. Beauchamp, Patrik K. E. Magnusson, M. Robinson, Chelsea Watson, Jian Yang, M. Johannesson, P. Visscher, Daniel J. Benjamin +336 moresemanticscholar +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceGenome-Wide Association Study of Bronchodilator Drug Response (BDR) in Minority Children with Asthma Provides Insights into Its Genetic Risk Factors [PDF]
, 2021 Jin Hui Joo, Angel C. Y. Mak, Shujie Xiao, Patrick Sleiman, Diane Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwadkar, Håkon Håkonarson, L. Keoki Williams, EG Burchard, Blanca E. Himes +12 moreopenalex +1 more sourceA Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Science, 2006 R. Duerr, K. Taylor, S. Brant, S. Brant, J. Rioux, J. Rioux, M. Silverberg, M. J. Daly, M. J. Daly, A. Steinhart, C. Abraham, M. Regueiro, A. Griffiths, T. Dassopoulos, A. Bitton, Huiying Yang, S. Targan, L. Datta, E. Kistner, L. P. Schumm, Annette Lee, P. Gregersen, M. Barmada, J. Rotter, Dan L. Nicolae, Judy H. Cho +25 moresemanticscholar +1 more sourceImproving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann +15 morewiley +1 more source
