Results 11 to 20 of about 685,002 (338)
Genome-Wide Association Studies of Asthma
Allergology International, 2011 Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.Mayumi Tamari, Kaori Tomita, Tomomitsu Hirota +2 moredoaj +4 more sourcesA genome-wide association study of anorexia nervosa. [PDF]
Molecular Psychiatry, 2014 Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results.A A van Elburg, A Bruson, A Farmer, A Favaro, A Hinney, A Julia, A Karwautz, A Keski-Rahkonen, A Lundervold, A Metspalu, A Palotie, A Raevuori, A Rajewski, A S Kaplan, A Scherag, A Schosser, A Slopien, A Tortorella, A Tsitsika, A Versini, Adrian Hill, Alexander P Maxwell, Anna Dominiczak, Audrey Duncanson, B Ding, B Herpertz-Dahlmann, B P C Koeleman, C Boni, C de Kovel, C Dina, C E Hilliard, C Finan, C M Bulik, C M Lewis, C S Franklin, C Taico, Carl A Anderson, Christopher S Franklin, Cordelia Langford, Cordelia Langford, Cynthia M Bulik, D A Collier, D Degortes, D Dikeos, D Koubek, D Li, D M Dick, D Martaskova, D Pinto, D Rujescu, D W Logan, David A Collier, David P Strachan, Douglas Simpkin, E Docampo, E F Van Furth, E Merl, E Strengman, E Tenconi, E Widén, E Zeggini, Eleftheria Zeggini, Emma Gray, F Fernández-Aranda, F Gonidakis, F Rybakowski, F Tozzi, Fredrik O Vannberg, G Breen, G Dedoussis, G Escaramís, G Gambaro, G Kalsi, G Komaki, G P S Knudsen, G R S Ritchie, G Wagner, Graeme Alexander, Graham Lord, H Aschauer, H Hakonarson, H Imgart, H Inoko, H Papezova, H-E Wichmann, Hannah Blackburn, I Giegling, I Jaussent, I Meulenbelt, I Ntalla, I Reinvang, I Tachmazidou, J A B Floyd, J C Barrett, J Dackor, J E DeSocio, J H Baker, J Hauser, J Hebebrand, J Hendriks, J Huemer, J I Hudson, J K O'Toole, J Kaprio, J L Kennedy, J Lissowska, J P Szatkiewicz, J Pantel, J Treasure, James A B Floyd, Jeffrey C Barrett, Jeffrey C Barrett, Jennifer Sambrook, Jonathan Stephens, K Bühren, K Egberts, K Fischer, K Kiezebrink, K L Klump, K Männik, K Tziouvas, L Alfredsson, L Carlberg, L Foretova, L Karhunen, L Klareskog, L M Huckins, L M Thornton, L Padyukov, L Peltonen, L Slachtova, L Southam, Leena Peltonen, Linda Morgan, M C T Slof-Op 't Landt, M Clementi, M de Zwaan, M Dmitrzak-Weglarz, M Forzan, M Gratacos, M J H Kas, M K Brandys, M Maj, M Mattingsdal, M Navratilova, M Roberts, Mathew Gillman, N J Schork, N Ramoz, N Soranzo, N Szeszenia-Dabrowska, N W Rayner, Neil Sheerin, Nicole Soranzo, Nicole Soranzo, null null, O A Andreassen, O S P Davis, P Courtet, P E Slagboom, P F Sullivan, P Gorwood, P Lichtenstein, P McGuffin, P Monteleone, P Santonastaso, Pamela Whittaker, Peter J Conlon, R A H Adan, R A Ophoff, R Burghardt, R D Cone, R D Levitan, R Rabionet, R Sladek, Ralph McGinnis, Richard N Sandford, S Cichon, S Cohen-Woods, S E Trace, S Ehrlich, S Gallinger, S Guillaume, S Helder, S Herms, S Jiménez-Murcia, S Le Hellard, S Marsal, S Ripatti, S Scherag, S Schreiber, S W Scherer, S Zerwas, S Zipfel, Sarah E Hunt, Sarah Edkins, Simon Potter, Stephen S Rich, Suna Onengut-Gumuscu, Susan M Ring, T Ando, T Esko, T Espeseth, T Reichborn-Kjennerud, U N Danner, U Schmidt, V Bencko, V Boraska, V Gaborieau, V Janout, V M Steen, W H Berrettini, W Herzog, Wei-Min Chen, Wendy L McArdle, Willem H Ouwehand, X Estivill, Y Guo, Z Yilmaz +218 morecore +19 more sourcesGenome-wide association studies [PDF]
Nature Reviews Methods Primers, 2021 Genome- wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology has generated a myriad of robust associations for a range of traits and diseases, and the number of associated variants is expected to grow steadily as GWAS ...Danielle Posthuma, Hilary C. Martin, Nchangwi Syntia Munung, Alicia R. Martin, Alicia R. Martin, Yukinori Okada, Jantina de Vries, Emil Uffelmann, Qin Qin Huang, Tuuli Lappalainen, Tuuli Lappalainen +10 moreopenaire +1 more sourceA genome-wide association study on medulloblastoma [PDF]
Journal of Neuro-Oncology, 2020 Abstract Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.Dahlin, Anna M., Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M., Scheurer, Michael E., Lau, Ching C., McKean-Cowdin, Roberta, Kennedy, Rebekah J., Hung, Long T., Yee, Janis, Margol, Ashley S., Barrington-Trimis, Jessica, Gauderman, W. James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Prochazka, Michaela, Adel Fahmideh, Maral, Lannering, Birgitta, Schmidt, Lisbeth S., Johansen, Christoffer, Sehested, Astrid, Kuehni, Claudia, Grotzer, Michael, Tynes, Tore, Eggen, Tone, Klaeboe, Lars, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, Melin, Beatrice S. +37 moreopenaire +6 more sourcesHow data science and AI-based technologies impact genomics
Singapore Medical Journal, 2023 Advancements in high-throughput sequencing have yielded vast amounts of genomic data, which are studied using genome-wide association study (GWAS)/phenome-wide association study (PheWAS) methods to identify associations between the genotype and phenotype.Jing Lin, Kee Yuan Ngiamdoaj +1 more sourceGenome-Wide Association Studies in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2011 Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.Sivapalaratnam, S., Motazacker, M.M., Maiwald, S., Hovingh, G.K., Kastelein, J.J.P., Levi, M., Trip, M.D., Dallinga-Thie, G.M. +7 moreopenaire +4 more sourcesrMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study
bioRxiv, 2020 Along with the development of high-throughout sequencing technologies, both sample size and number of SNPs are increasing rapidly in Genome-Wide Association Studies (GWAS) and the associated computation is more challenging than ever.Lilin Yin, Haohao Zhang, Zhenshuang Tang, Jingya Xu, Dong Yin, Zhiwu Zhang, Xiaohui Yuan, Mengjin Zhu, Shuhong Zhao, Xinyun Li, Xiaolei Liu +10 moresemanticscholar +1 more sourceDissecting the genetic heterogeneity of gastric cancerResearch in context
EBioMedicine, 2023 Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher +133 moredoaj +1 more source
