Results 11 to 20 of about 1,051,148 (367)
A genome-wide association study of anorexia nervosa [PDF]
Molecular Psychiatry, 2014 Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls ...V. Boraska, C. S. Franklin, J. A. B. Floyd, L. M. Thornton, L. M. Huckins, L. Southam, N. W. Rayner, I. Tachmazidou, K. L. Klump, J. Treasure, C. M. Lewis, U. Schmidt, F. Tozzi, K. Kiezebrink, J. Hebebrand, P. Gorwood, R. A. H. Adan, M. J. H. Kas, FAVARO, ANGELA, SANTONASTASO, PAOLO, F. Fernández Aranda, M. Gratacos, F. Rybakowski, M. Dmitrzak Weglarz, J. Kaprio, A. Keski Rahkonen, A. Raevuori, E. F. Van Furth, M. C. T. Slof Op 't Landt, J. I. Hudson, T. Reichborn Kjennerud, G. P. S. Knudsen, P. Monteleone, A. S. Kaplan, A. Karwautz, H. Hakonarson, W. H. Berrettini, Y. Guo, D. Li, N. J. Schork, G. Komaki, T. Ando, H. Inoko, T. Esko, K. Fischer, K. Männik, A. Metspalu, J. H. Baker, R. D. Cone, J. Dackor, J. E. DeSocio, C. E. Hilliard, J. K. O'Toole, J. Pantel, J. P. Szatkiewicz, C. Taico, S. Zerwas, S. E. Trace, O. S. P. Davis, S. Helder, K. Bühren, R. Burghardt, M. de Zwaan, K. Egberts, S. Ehrlich, B. Herpertz Dahlmann, W. Herzog, H. Imgart, A. Scherag, S. Scherag, S. Zipfel, C. Boni, N. Ramoz, A. Versini, M. K. Brandys, U. N. Danner, C. de Kovel, J. Hendriks, B. P. C. Koeleman, R. A. Ophoff, E. Strengman, A. A. van Elburg, BRUSON, ALICE, CLEMENTI, MAURIZIO, DEGORTES, DANIELA, FORZAN, MONICA, TENCONI, ELENA, E. Docampo, G. Escaramís, S. Jiménez Murcia, J. Lissowska, A. Rajewski, N. Szeszenia Dabrowska, A. Slopien, J. Hauser, L. Karhunen, I. Meulenbelt, P. E. Slagboom, A. Tortorella, M. Maj, G. Dedoussis, D. Dikeos, F. Gonidakis, K. Tziouvas, A. Tsitsika, H. Papezova, L. Slachtova, D. Martaskova, J. L. Kennedy, R. D. Levitan, Z. Yilmaz, J. Huemer, D. Koubek, E. Merl, G. Wagner, P. Lichtenstein, G. Breen, S. Cohen Woods, A. Farmer, P. McGuffin, S. Cichon, I. Giegling, S. Herms, D. Rujescu, S. Schreiber, H. E. Wichmann, C. Dina, R. Sladek, G. Gambaro, N. Soranzo, A. Julia, S. Marsal, R. Rabionet, V. Gaborieau, D. M. Dick, A. Palotie, S. Ripatti, E. Widén, O. A. Andreassen, T. Espeseth, A. Lundervold, I. Reinvang, V. M. Steen, S. Le Hellard, M. Mattingsdal, I. Ntalla, V. Bencko, L. Foretova, V. Janout, M. Navratilova, S. Gallinger, D. Pinto, S. W. Scherer, H. Aschauer, L. Carlberg, A. Schosser, L. Alfredsson, B. Ding, L. Klareskog, L. Padyukov, P. Courtet, S. Guillaume, I. Jaussent, C. Finan, G. Kalsi, M. Roberts, D. W. Logan, L. Peltonen, G. R. S. Ritchie, J. C. Barrett, Carl A. Anderson, Jeffrey C. Barrett, James A. B. Floyd, Christopher S. Franklin, Ralph McGinnis, Nicole Soranzo, Eleftheria Zeggini, Jennifer Sambrook, Jonathan Stephens, Willem H. Ouwehand, Wendy L. McArdle, Susan M. Ring, David P. Strachan, Graeme Alexander, Cynthia M. Bulik, David A. Collier, Peter J. Conlon, Anna Dominiczak, Audrey Duncanson, Adrian Hill, Cordelia Langford, Graham Lord, Alexander P. Maxwell, Linda Morgan, Leena Peltonen, Richard N. Sandford, Neil Sheerin, Nicole Soranzo, Fredrik O. Vannberg, Jeffrey C. Barrett, Sarah Edkins, Stephen S. Rich, X. Estivill, A. Hinney +203 morecore +23 more sourcesGenome-Wide Association Studies of Asthma
Allergology International, 2011 Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.Mayumi Tamari, Kaori Tomita, Tomomitsu Hirota +2 moredoaj +4 more sourcesGenome-wide association with select biomarker traits in the Framingham Heart Study [PDF]
, 2007 BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes.Emelia J. Benjamin, Josée Dupuis, Martin G. Larson, Kathryn L. Lunetta, Sarah L. Booth, Diddahally R. Govindaraju, Sekar Kathiresan, John F. Keaney, Michelle J. Keyes, Jing‐Ping Lin, James B. Meigs, Sander J. Robins, Jian Rong, Renate B. Schnabel, Joseph A. Vita, Thomas J. Wang, Peter W.F. Wilson, Philip A. Wolf, Ramachandran S. Vasan +18 morecore +16 more sourcesGenome-wide association studies [PDF]
Nature Reviews Methods Primers, 2021 Genome- wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology has generated a myriad of robust associations for a range of traits and diseases, and the number of associated variants is expected to grow steadily as GWAS ...Danielle Posthuma, Hilary C. Martin, Nchangwi Syntia Munung, Alicia R. Martin, Alicia R. Martin, Yukinori Okada, Jantina de Vries, Emil Uffelmann, Qin Qin Huang, Tuuli Lappalainen, Tuuli Lappalainen +10 moreopenaire +1 more sourceNovel associations for hypothyroidism include known autoimmune risk loci [PDF]
, 2011 Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,A Alcina, A Bender, A Petrone, A Teumer, A Zhernakova, AA Zeitlin, Amr H. Sawalha, Amy K. Kiefer, C Cotsapas, C Newton-Cheh, CB Do, Chuong B. Do, D Falush, D Smyth, David A. Hinds, F Menconi, G Lettre, H Donner, H Fraser, H Hakonarson, H Ikegami, I Landa, J Gudmundsson, J Lowe, JA Todd, JC Barrett, JC Denny, JE Wigginton, JH Cho, Joanna L. Mountain, Joyce Y. Tung, K Fujikawa, L Arnaud-Lopez, L Criswell, M Castanet, M Hayashi, M Sirota, M Velaga, MJ Coenen, MJ Simmonds, N Eriksson, N Movilla, N Tandon, Nicholas Eriksson, P Burton, P Chen, P Gourh, P Gregersen, P Newby, RC Betz, RJ Pruim, SM Park, TJ Giordano, Uta Francke, V Panicker, X Chu, Y Tomer, YH Lee +57 morecore +23 more sourcesA genome-wide association study on medulloblastoma [PDF]
Journal of Neuro-Oncology, 2020 Abstract Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.Dahlin, Anna M., Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M., Scheurer, Michael E., Lau, Ching C., McKean-Cowdin, Roberta, Kennedy, Rebekah J., Hung, Long T., Yee, Janis, Margol, Ashley S., Barrington-Trimis, Jessica, Gauderman, W. James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Prochazka, Michaela, Adel Fahmideh, Maral, Lannering, Birgitta, Schmidt, Lisbeth S., Johansen, Christoffer, Sehested, Astrid, Kuehni, Claudia, Grotzer, Michael, Tynes, Tore, Eggen, Tone, Klaeboe, Lars, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, Melin, Beatrice S. +37 moreopenaire +6 more sourcesGenome-Wide Association Studies in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2011 Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.Sivapalaratnam, S., Motazacker, M.M., Maiwald, S., Hovingh, G.K., Kastelein, J.J.P., Levi, M., Trip, M.D., Dallinga-Thie, G.M. +7 moreopenaire +4 more sourcesCommon variants in FOXP1 are associated with generalized vitiligo [PDF]
, 2010 In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, A Alkhateeb, Alain Taïeb, Andreas Overbeck, Anthony P Weetman, C Shi, Christina M Mailloux, David J Gawkrodger, DF Luo, Dorothy C Bennett, E Helen Kemp, Giovanni Leone, H Hu, HD Ochs, JC Barrett, Jo Lambert, Katherine Gowan, Khaled Ezzedine, Margaret R Wallace, Mauro Picardo, Nanny van Geel, Pamela R Fain, Paulene J Holland, RA Spritz, Richard A Spritz, RM Salazar-Gonzalez, S Horvath, S Purcell, SA Birlea, Sheri L Riccardi, Stanca A Birlea, Thomas Jouary, Wayne T McCormack, X Feng, Y Jin, Ying Jin +34 morecore +5 more sourcesrMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study
bioRxiv, 2020 Along with the development of high-throughout sequencing technologies, both sample size and number of SNPs are increasing rapidly in Genome-Wide Association Studies (GWAS) and the associated computation is more challenging than ever.Lilin Yin, Haohao Zhang, Zhenshuang Tang, Jingya Xu, Dong Yin, Zhiwu Zhang, Xiaohui Yuan, Mengjin Zhu, Shuhong Zhao, Xinyun Li, Xiaolei Liu +10 moresemanticscholar +1 more source
