Results 11 to 20 of about 1,303,219 (221)
Genome-Wide Association Studies of Asthma
Allergology International, 2011 Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.Mayumi Tamari, Kaori Tomita, Tomomitsu Hirota +2 moredoaj +4 more sourcesGenome-wide association studies [PDF]
Nature Reviews Methods Primers, 2021 Genome- wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology has generated a myriad of robust associations for a range of traits and diseases, and the number of associated variants is expected to grow steadily as GWAS ...Danielle Posthuma, Hilary C. Martin, Nchangwi Syntia Munung, Alicia R. Martin, Alicia R. Martin, Yukinori Okada, Jantina de Vries, Emil Uffelmann, Qin Qin Huang, Tuuli Lappalainen, Tuuli Lappalainen +10 moreopenaire +1 more sourceA genome-wide association study on medulloblastoma [PDF]
Journal of Neuro-Oncology, 2020 Abstract Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.Dahlin, Anna M., Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M., Scheurer, Michael E., Lau, Ching C., McKean-Cowdin, Roberta, Kennedy, Rebekah J., Hung, Long T., Yee, Janis, Margol, Ashley S., Barrington-Trimis, Jessica, Gauderman, W. James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Prochazka, Michaela, Adel Fahmideh, Maral, Lannering, Birgitta, Schmidt, Lisbeth S., Johansen, Christoffer, Sehested, Astrid, Kuehni, Claudia, Grotzer, Michael, Tynes, Tore, Eggen, Tone, Klaeboe, Lars, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, Melin, Beatrice S. +37 moreopenaire +6 more sourcesGenome-Wide Association Studies in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2011 Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.S. Sivapalaratnam, M.M. Motazacker, S. Maiwald, G.K. Hovingh, J.J.P. Kastelein, M. Levi, M.D. Trip, G.M. Dallinga-Thie +7 moreopenaire +3 more sourcesGenome-wide association studies in ADHD [PDF]
Human Genetics, 2009 Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find genes underlying the disorder. ADHD is a multifactorial disorder, in which many genes, all with a small effect, are thought to cause ...Barbara Franke, Benjamin M. Neale, Benjamin M. Neale, Benjamin M. Neale, Stephen V. Faraone +4 moreopenaire +5 more sourcesGenome-wide association studies: a primer [PDF]
Psychological Medicine, 2009 There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of Patrick F. Sullivan, Nicholas John Craddock, Aiden Corvin +2 moreopenaire +5 more sourcesA Genome-Wide Association Study of Depressive Symptoms [PDF]
Biological Psychiatry, 2013 Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms.In this genome-wide association study, we combined the results of 17 population ...Antonella Mulas, Majken K. Jensen, Gary C. Curhan, Nona Sotoodehnia, Kenneth Rice, Cornelis L. Mulder, Maris Kuningas, Cornelia M. van Duijn, Andrea Schulz, Astrid Petersmann, Stefania Bandinelli, Frank B. Hu, Ben A. Oostra, Thomas Illig, Karestan C. Koenen, Yongmei Liu, Tamara B. Harris, Kristin D. Marciante, Kathryn L. Lunetta, Margaret Kelly-Hayes, André G. Uitterlinden, Lenore J. Launer, Sharon L.R. Kardia, Marilyn C. Cornelis, David A. Bennett, Peter Kraft, Joseph M. Massaro, Brenda W.J.H. Penninx, Anne B. Newman, Jari Lahti, Jari Lahti, Antonio Terracciano, Karl-Heinz Ladwig, Angelina R. Sutin, Angelina R. Sutin, Mike A. Nalls, Lei Yu, Najaf Amin, Andrew B. Singleton, Jingzhong Ding, Thomas H. Mosley, Osorio Meirelles, Shaun Purcell, Karin Hek, Henning Tiemeier, Yan V. Sun, Erin Bakshis, Hans J. Grabe, Jerome I. Rotter, Aarno Palotie, Rebecca T. Emeny, Emelia J. Benjamin, Eco J. C. de Geus, Jens Baumert, Albert V. Smith, David J. Hunter, David Melzer, Kristine Yaffe, Luigi Ferrucci, Alan B. Zonderman, Laura H. Coker, Alan D. Penman, Henry Völzke, Katri Räikkönen, Alessandra Cannas, Ana V. Diez-Roux, Anna Murray, Denis A. Evans, Elisabeth Widen, Albert Hofman, Dorret I. Boomsma, Vilmundur Gudnason, Rajesh Rawal, Myriam Fornage, Johan G. Eriksson, Bruce M. Psaty, David J. Llewellyn, Luke C. Pilling, Toshiko Tanaka, Nicole Vogelzangs, Alexander Teumer, Eric B. Rimm, Francesco Cucca, Joanne M. Murabito, Philip L. De Jager, Eric M. Reiman, Joshua M. Shulman, Ayse Demirkan +87 moreopenaire +12 more sourcesA genome-wide association study of anorexia nervosa [PDF]
Molecular Psychiatry, 2014 Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls ...V. Boraska, C. S. Franklin, J. A. B. Floyd, L. M. Thornton, L. M. Huckins, L. Southam, N. W. Rayner, I. Tachmazidou, K. L. Klump, J. Treasure, C. M. Lewis, U. Schmidt, F. Tozzi, K. Kiezebrink, J. Hebebrand, P. Gorwood, R. A. H. Adan, M. J. H. Kas, FAVARO, ANGELA, SANTONASTASO, PAOLO, F. Fernández Aranda, M. Gratacos, F. Rybakowski, M. Dmitrzak Weglarz, J. Kaprio, A. Keski Rahkonen, A. Raevuori, E. F. Van Furth, M. C. T. Slof Op 't Landt, J. I. Hudson, T. Reichborn Kjennerud, G. P. S. Knudsen, P. Monteleone, A. S. Kaplan, A. Karwautz, H. Hakonarson, W. H. Berrettini, Y. Guo, D. Li, N. J. Schork, G. Komaki, T. Ando, H. Inoko, T. Esko, K. Fischer, K. Männik, A. Metspalu, J. H. Baker, R. D. Cone, J. Dackor, J. E. DeSocio, C. E. Hilliard, J. K. O'Toole, J. Pantel, J. P. Szatkiewicz, C. Taico, S. Zerwas, S. E. Trace, O. S. P. Davis, S. Helder, K. Bühren, R. Burghardt, M. de Zwaan, K. Egberts, S. Ehrlich, B. Herpertz Dahlmann, W. Herzog, H. Imgart, A. Scherag, S. Scherag, S. Zipfel, C. Boni, N. Ramoz, A. Versini, M. K. Brandys, U. N. Danner, C. de Kovel, J. Hendriks, B. P. C. Koeleman, R. A. Ophoff, E. Strengman, A. A. van Elburg, BRUSON, ALICE, CLEMENTI, MAURIZIO, DEGORTES, DANIELA, FORZAN, MONICA, TENCONI, ELENA, E. Docampo, G. Escaramís, S. Jiménez Murcia, J. Lissowska, A. Rajewski, N. Szeszenia Dabrowska, A. Slopien, J. Hauser, L. Karhunen, I. Meulenbelt, P. E. Slagboom, A. Tortorella, M. Maj, G. Dedoussis, D. Dikeos, F. Gonidakis, K. Tziouvas, A. Tsitsika, H. Papezova, L. Slachtova, D. Martaskova, J. L. Kennedy, R. D. Levitan, Z. Yilmaz, J. Huemer, D. Koubek, E. Merl, G. Wagner, P. Lichtenstein, G. Breen, S. Cohen Woods, A. Farmer, P. McGuffin, S. Cichon, I. Giegling, S. Herms, D. Rujescu, S. Schreiber, H. E. Wichmann, C. Dina, R. Sladek, G. Gambaro, N. Soranzo, A. Julia, S. Marsal, R. Rabionet, V. Gaborieau, D. M. Dick, A. Palotie, S. Ripatti, E. Widén, O. A. Andreassen, T. Espeseth, A. Lundervold, I. Reinvang, V. M. Steen, S. Le Hellard, M. Mattingsdal, I. Ntalla, V. Bencko, L. Foretova, V. Janout, M. Navratilova, S. Gallinger, D. Pinto, S. W. Scherer, H. Aschauer, L. Carlberg, A. Schosser, L. Alfredsson, B. Ding, L. Klareskog, L. Padyukov, P. Courtet, S. Guillaume, I. Jaussent, C. Finan, G. Kalsi, M. Roberts, D. W. Logan, L. Peltonen, G. R. S. Ritchie, J. C. Barrett, Carl A. Anderson, Jeffrey C. Barrett, James A. B. Floyd, Christopher S. Franklin, Ralph McGinnis, Nicole Soranzo, Eleftheria Zeggini, Jennifer Sambrook, Jonathan Stephens, Willem H. Ouwehand, Wendy L. McArdle, Susan M. Ring, David P. Strachan, Graeme Alexander, Cynthia M. Bulik, David A. Collier, Peter J. Conlon, Anna Dominiczak, Audrey Duncanson, Adrian Hill, Cordelia Langford, Graham Lord, Alexander P. Maxwell, Linda Morgan, Leena Peltonen, Richard N. Sandford, Neil Sheerin, Nicole Soranzo, Fredrik O. Vannberg, Jeffrey C. Barrett, Sarah Edkins, Sarah E. Hunt, Stephen S. Rich, X. Estivill, A. Hinney +204 moreopenaire +15 more sourcesGenome-wide association studies in mice [PDF]
Nature Reviews Genetics, 2012 Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice.Flint, J, Eskin, Eopenaire +4 more sources
