Results 21 to 30 of about 1,051,148 (367)

Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gut Pathogens, 2021
Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang   +12 more
doaj   +1 more source

Genome-wide association studies in ADHD [PDF]

Human Genetics, 2009
Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find genes underlying the disorder. ADHD is a multifactorial disorder, in which many genes, all with a small effect, are thought to cause ...
Barbara Franke, Benjamin M. Neale, Benjamin M. Neale, Benjamin M. Neale, Stephen V. Faraone   +4 more
openaire   +5 more sources

Genome-wide association studies: a primer [PDF]

Psychological Medicine, 2009
There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of
Patrick F. Sullivan, Nicholas John Craddock, Aiden Corvin   +2 more
openaire   +5 more sources

Genome-wide association study of male sexual orientation [PDF]

, 2017
Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men ...
Cloninger, C. Robert, et al,, Svrakic, Dragan M   +2 more
core   +5 more sources

Genome-wide associate study identifies five new schizophrenia loci [PDF]

, 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent ...
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
core   +2 more sources

A Genome-Wide Association Study of Depressive Symptoms [PDF]

Biological Psychiatry, 2013
Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms.In this genome-wide association study, we combined the results of 17 population ...
Antonella Mulas, Majken K. Jensen, Gary C. Curhan, Nona Sotoodehnia, Kenneth Rice, Cornelis L. Mulder, Maris Kuningas, Cornelia M. van Duijn, Andrea Schulz, Astrid Petersmann, Stefania Bandinelli, Frank B. Hu, Ben A. Oostra, Thomas Illig, Karestan C. Koenen, Yongmei Liu, Tamara B. Harris, Kristin D. Marciante, Kathryn L. Lunetta, Margaret Kelly-Hayes, André G. Uitterlinden, Lenore J. Launer, Sharon L.R. Kardia, Marilyn C. Cornelis, David A. Bennett, Peter Kraft, Joseph M. Massaro, Brenda W.J.H. Penninx, Anne B. Newman, Jari Lahti, Jari Lahti, Antonio Terracciano, Karl-Heinz Ladwig, Angelina R. Sutin, Angelina R. Sutin, Mike A. Nalls, Lei Yu, Najaf Amin, Andrew B. Singleton, Jingzhong Ding, Thomas H. Mosley, Osorio Meirelles, Shaun Purcell, Karin Hek, Henning Tiemeier, Yan V. Sun, Erin Bakshis, Hans J. Grabe, Jerome I. Rotter, Aarno Palotie, Rebecca T. Emeny, Emelia J. Benjamin, Eco J. C. de Geus, Jens Baumert, Albert V. Smith, David J. Hunter, David Melzer, Kristine Yaffe, Luigi Ferrucci, Alan B. Zonderman, Laura H. Coker, Alan D. Penman, Henry Völzke, Katri Räikkönen, Alessandra Cannas, Ana V. Diez-Roux, Anna Murray, Denis A. Evans, Elisabeth Widen, Albert Hofman, Dorret I. Boomsma, Vilmundur Gudnason, Rajesh Rawal, Myriam Fornage, Johan G. Eriksson, Bruce M. Psaty, David J. Llewellyn, Luke C. Pilling, Toshiko Tanaka, Nicole Vogelzangs, Alexander Teumer, Eric B. Rimm, Francesco Cucca, Joanne M. Murabito, Philip L. De Jager, Eric M. Reiman, Joshua M. Shulman, Ayse Demirkan   +87 more
openaire   +12 more sources

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease [PDF]

, 2011
We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed.
A Lerner, A Ruepp, AA Merchant, AM Glazer, B Bakir-Gungor, B Dass, C Wolff, CB Do, CH Hawkes, D Subramaniam, DAD Monte, DI Chasman, E Eskin, FL Moore, H-C Fung, HR Kim, J Simón-Sánchez, K Lai, K Roeder, K Roeder, K Roeder, K Sekimizu, K Tsuboi, L Lum, LA Hindorff, LM Bekris, M Bak, M Plaisant, M Saad, M-X Li, N Miao, O Bragina, P Mill, P Whitton, PA Beachy, PW Ingham, RE Lamont, S Purcell, SM Chambers, SY Tay, TA Manolio, TH Hamza, TL Edwards, TS Keshava Prasad, V Palma, VF Rafuse, W Satake, Y Katoh   +47 more
core   +3 more sources

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Psoriasis: An Immunogenetic Perspective

Global Medical Genetics, 2022
Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease.
Ayca Kocaaga, Mustafa Kocaaga
doaj   +1 more source

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes

Nature Genetics, 2009
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date.
D. Harold, R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M. Hamshere, Jaspreet Singh Pahwa, V. Moskvina, Kimberley Dowzell, Amy J. Williams, N. Jones, C. Thomas, A. Stretton, A. Morgan, S. Lovestone, J. Powell, P. Proitsi, Michelle K. Lupton, C. Brayne, D. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K. Brown, P. Passmore, D. Craig, B. McGuinness, S. Todd, C. Holmes, D. Mann, A. Smith, S. Love, P. Kehoe, J. Hardy, S. Mead, Nick C Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, B. Schürmann, H. van den Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frölich, H. Hampel, M. Hüll, D. Rujescu, A. Goate, J. Kauwe, Carlos Cruchaga, P. Nowotny, J. Morris, K. Mayo, K. Sleegers, K. Bettens, S. Engelborghs, P. D. de Deyn, C. van Broeckhoven, G. Livingston, N. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, A. Al-Chalabi, C. Shaw, M. Tsolaki, A. Singleton, R. Guerreiro, Thomas W. Mühleisen, M. Nöthen, S. Moebus, K. Jöckel, N. Klopp, H. Wichmann, M. Carrasquillo, V. Pankratz, S. Younkin, P. Holmans, M. O’Donovan, M. Owen, Julie Williams   +85 more
semanticscholar   +2 more sources