Results 21 to 30 of about 685,002 (338)
Genome-wide association studies in ADHD [PDF]
Human Genetics, 2009 Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find genes underlying the disorder. ADHD is a multifactorial disorder, in which many genes, all with a small effect, are thought to cause ...Barbara Franke, Benjamin M. Neale, Benjamin M. Neale, Benjamin M. Neale, Stephen V. Faraone +4 moreopenaire +5 more sourcesTranscriptome-wide association study identified candidate genes associated with gut microbiota
Gut Pathogens, 2021 Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang +12 moredoaj +1 more sourceGenome-wide association studies: a primer [PDF]
Psychological Medicine, 2009 There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of Patrick F. Sullivan, Nicholas John Craddock, Aiden Corvin +2 moreopenaire +5 more sourcesCommon variants in FOXP1 are associated with generalized vitiligo [PDF]
, 2010 In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, A Alkhateeb, Alain Taïeb, Andreas Overbeck, Anthony P Weetman, C Shi, Christina M Mailloux, David J Gawkrodger, DF Luo, Dorothy C Bennett, E Helen Kemp, Giovanni Leone, H Hu, HD Ochs, JC Barrett, Jo Lambert, Katherine Gowan, Khaled Ezzedine, Margaret R Wallace, Mauro Picardo, Nanny van Geel, Pamela R Fain, Paulene J Holland, RA Spritz, Richard A Spritz, RM Salazar-Gonzalez, S Horvath, S Purcell, SA Birlea, Sheri L Riccardi, Stanca A Birlea, Thomas Jouary, Wayne T McCormack, X Feng, Y Jin, Ying Jin +34 morecore +2 more sourcesA Genome-Wide Association Study of Depressive Symptoms [PDF]
Biological Psychiatry, 2013 Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms.In this genome-wide association study, we combined the results of 17 population ...Antonella Mulas, Majken K. Jensen, Gary C. Curhan, Nona Sotoodehnia, Kenneth Rice, Cornelis L. Mulder, Maris Kuningas, Cornelia M. van Duijn, Andrea Schulz, Astrid Petersmann, Stefania Bandinelli, Frank B. Hu, Ben A. Oostra, Thomas Illig, Karestan C. Koenen, Yongmei Liu, Tamara B. Harris, Kristin D. Marciante, Kathryn L. Lunetta, Margaret Kelly-Hayes, André G. Uitterlinden, Lenore J. Launer, Sharon L.R. Kardia, Marilyn C. Cornelis, David A. Bennett, Peter Kraft, Joseph M. Massaro, Brenda W.J.H. Penninx, Anne B. Newman, Jari Lahti, Jari Lahti, Antonio Terracciano, Karl-Heinz Ladwig, Angelina R. Sutin, Angelina R. Sutin, Mike A. Nalls, Lei Yu, Najaf Amin, Andrew B. Singleton, Jingzhong Ding, Thomas H. Mosley, Osorio Meirelles, Shaun Purcell, Karin Hek, Henning Tiemeier, Yan V. Sun, Erin Bakshis, Hans J. Grabe, Jerome I. Rotter, Aarno Palotie, Rebecca T. Emeny, Emelia J. Benjamin, Eco J. C. de Geus, Jens Baumert, Albert V. Smith, David J. Hunter, David Melzer, Kristine Yaffe, Luigi Ferrucci, Alan B. Zonderman, Laura H. Coker, Alan D. Penman, Henry Völzke, Katri Räikkönen, Alessandra Cannas, Ana V. Diez-Roux, Anna Murray, Denis A. Evans, Elisabeth Widen, Albert Hofman, Dorret I. Boomsma, Vilmundur Gudnason, Rajesh Rawal, Myriam Fornage, Johan G. Eriksson, Bruce M. Psaty, David J. Llewellyn, Luke C. Pilling, Toshiko Tanaka, Nicole Vogelzangs, Alexander Teumer, Eric B. Rimm, Francesco Cucca, Joanne M. Murabito, Philip L. De Jager, Eric M. Reiman, Joshua M. Shulman, Ayse Demirkan +87 moreopenaire +12 more sourcesGenome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci
Breast Cancer Research, 2022 Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström +56 moredoaj +1 more sourceA genome‐wide association study of the frailty index highlights brain pathways in ageing
Aging Cell, 2021 Frailty is a common geriatric syndrome and strongly associated with disability, mortality and hospitalization. Frailty is commonly measured using the frailty index (FI), based on the accumulation of a number of health deficits during the life course. The J. Atkins, J. Jylhävä, N. Pedersen, P. Magnusson, Yi Lu, Yunzhang Wang, S. Hägg, D. Melzer, Dylan M. Williams, L. Pilling +9 moresemanticscholar +1 more sourceGenome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes
Nature Genetics, 2009 We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date.D. Harold, R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M. Hamshere, Jaspreet Singh Pahwa, V. Moskvina, Kimberley Dowzell, Amy J. Williams, N. Jones, C. Thomas, A. Stretton, A. Morgan, S. Lovestone, J. Powell, P. Proitsi, Michelle K. Lupton, C. Brayne, D. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K. Brown, P. Passmore, D. Craig, B. McGuinness, S. Todd, C. Holmes, D. Mann, A. Smith, S. Love, P. Kehoe, J. Hardy, S. Mead, Nick C Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, B. Schürmann, H. van den Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frölich, H. Hampel, M. Hüll, D. Rujescu, A. Goate, J. Kauwe, Carlos Cruchaga, P. Nowotny, J. Morris, K. Mayo, K. Sleegers, K. Bettens, S. Engelborghs, P. D. de Deyn, C. van Broeckhoven, G. Livingston, N. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, A. Al-Chalabi, C. Shaw, M. Tsolaki, A. Singleton, R. Guerreiro, Thomas W. Mühleisen, M. Nöthen, S. Moebus, K. Jöckel, N. Klopp, H. Wichmann, M. Carrasquillo, V. Pankratz, S. Younkin, P. Holmans, M. O’Donovan, M. Owen, Julie Williams +85 moresemanticscholar +2 more sources
