Results 31 to 40 of about 1,101,785 (286)

Common variants in FOXP1 are associated with generalized vitiligo [PDF]

, 2010
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent,
A Alkhateeb, Alain Taïeb, Andreas Overbeck, Anthony P Weetman, C Shi, Christina M Mailloux, David J Gawkrodger, DF Luo, Dorothy C Bennett, E Helen Kemp, Giovanni Leone, H Hu, HD Ochs, JC Barrett, Jo Lambert, Katherine Gowan, Khaled Ezzedine, Margaret R Wallace, Mauro Picardo, Nanny van Geel, Pamela R Fain, Paulene J Holland, RA Spritz, Richard A Spritz, RM Salazar-Gonzalez, S Horvath, S Purcell, SA Birlea, Sheri L Riccardi, Stanca A Birlea, Thomas Jouary, Wayne T McCormack, X Feng, Y Jin, Ying Jin   +34 more
core   +2 more sources

Genome-wide Association Study for AKI

Kidney360, 2023
Key Points Two genetic variants in the DISP1-TLR5 gene locus were associated with risk of AKI.DISP1 and TLR5 were differentially regulated in kidney biopsy tissue from patients with AKI compared with no AKI. Background
Pavan K. Bhatraju, Ian B. Stanaway, Melody R. Palmer, Rajasree Menon, Jennifer A. Schaub, Steven Menez, Anand Srivastava, F. Perry Wilson, Krzysztof Kiryluk, Paul M. Palevsky, Abhijit S. Naik, Sana S. Sakr, Gail P. Jarvik, Chirag R. Parikh, Lorraine B. Ware, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Steve G. Coca, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Mark M. Wurfel   +24 more
openaire   +2 more sources

Genome-Wide Association Studies of Cancer [PDF]

Journal of Clinical Oncology, 2010
Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Zsofia K, Stadler, Peter, Thom, Mark E, Robson, Jeffrey N, Weitzel, Noah D, Kauff, Karen E, Hurley, Vincent, Devlin, Bert, Gold, Robert J, Klein, Kenneth, Offit   +9 more
openaire   +2 more sources

Genome-wide association study of male sexual orientation [PDF]

, 2017
Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men ...
Cloninger, C. Robert, et al,, Svrakic, Dragan M   +2 more
core   +5 more sources

A genome‐wide association study of the frailty index highlights brain pathways in ageing

Aging Cell, 2021
Frailty is a common geriatric syndrome and strongly associated with disability, mortality and hospitalization. Frailty is commonly measured using the frailty index (FI), based on the accumulation of a number of health deficits during the life course. The
J. Atkins, J. Jylhävä, N. Pedersen, P. Magnusson, Yi Lu, Yunzhang Wang, S. Hägg, D. Melzer, Dylan M. Williams, L. Pilling   +9 more
semanticscholar   +1 more source

Genome-wide association studies in cancer [PDF]

Human Molecular Genetics, 2008
Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F, Easton, Rosalind A, Eeles
openaire   +2 more sources

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes

Nature Genetics, 2009
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date.
D. Harold, R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M. Hamshere, Jaspreet Singh Pahwa, V. Moskvina, Kimberley Dowzell, Amy J. Williams, N. Jones, C. Thomas, A. Stretton, A. Morgan, S. Lovestone, J. Powell, P. Proitsi, Michelle K. Lupton, C. Brayne, D. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K. Brown, P. Passmore, D. Craig, B. McGuinness, S. Todd, C. Holmes, D. Mann, A. Smith, S. Love, P. Kehoe, J. Hardy, S. Mead, Nick C Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, B. Schürmann, H. van den Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frölich, H. Hampel, M. Hüll, D. Rujescu, A. Goate, J. Kauwe, Carlos Cruchaga, P. Nowotny, J. Morris, K. Mayo, K. Sleegers, K. Bettens, S. Engelborghs, P. D. de Deyn, C. van Broeckhoven, G. Livingston, N. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, A. Al-Chalabi, C. Shaw, M. Tsolaki, A. Singleton, R. Guerreiro, Thomas W. Mühleisen, M. Nöthen, S. Moebus, K. Jöckel, N. Klopp, H. Wichmann, M. Carrasquillo, V. Pankratz, S. Younkin, P. Holmans, M. O’Donovan, M. Owen, Julie Williams   +85 more
semanticscholar   +2 more sources

Genome-wide association study of Tourette Syndrome [PDF]

, 2014
Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we
Anderson, Kelley, Barr, Cathy L, Benarroch, Fortu, Berrío, Gabriel Bedoya, Bruun, Ruth D., Budman, Cathy L., Campbell, Desmond, Cath, Danielle C, Chouinard, Sylvain, Conti, David V., Cox, Nancy J., Crane, Jacquelyn, Crenshaw, Andrew T., Davarya, Sarah, Davis, Lea K, Dion, Yves, Duarte, Ana V. Valencia, Edlund, Christopher K., Erenberg, Gerald, Eskin, Eleazar, Evans, Patrick, Fagerness, Jesen A, Fernandez, Thomas, Fournier, Eduardo, Freimer, Nelson, Gamazon, Eric, Gibbs, J. Raphael, Gilbert, Donald L., Girard, Simon, Grados, Marco A., Gross-Tsur, Varda, Han, Buhm, Hardy, John, Heiman, Gary A., Herrera, Luis Diego, Heutink, Peter, Hoekstra, Pieter J., Illmann, Cornelia, Jankovic, Joseph, Kidd, Judith R., Kidd, Kenneth K., King, Robert A., Knowles, James A., Konkashbaev, Anuar, Kremeyer, Barbara, Kurlan, Roger, Leckman, James F., Lee, Paul C, Leppert, Mark, Liu, Chunyu, Lowe, Thomas L., Lyon, Gholson J, Mathews, Carol A., McMahon, William, Mirel, Daniel B., Moessner, Rainald, Moorjani, Priya, Morgan, Jubel, Muller, Heike, Naarden, Allan L, Neale, Benjamin M., Ochoa, William Cornejo, Oostra, Ben A., Ophoff, Roel, Osiecki, Lisa, Pakstis, Andrew J., Parkin, Melissa A., Pauls, David L., Phan, Nam, Pluzhnikov, Anna, Pollak, Yehuda, Posthuma, Danielle, Purcell, Shaun, Rangel-Lugo, Martha, Restrepo, Sandra C. Mesa, Reus, Victor I., Robertson, Mary M., Romero, Roxana, Rouleau, Guy A., Ruiz-Linares, Andres, Sabatti, Chiara, Sandor, Paul, Scharf, Jeremiah M., Service, Susan, Silgado, Julio C. Cardona, Singer, Harvey, Singleton, Andrew, Smit, Jan H, State, Matthew, Stewart, S. Evelyn, Strengman, Eric, Tikhomirov, Anna, Tischfield, Jay A., Wagner, Michael, Walkup, John, Weiss, Nicholas, Weiss, Robert, Yu, Dongmei   +97 more
core   +1 more source

Genome-wide association studies in ADHD [PDF]

Human Genetics, 2009
Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find genes underlying the disorder. ADHD is a multifactorial disorder, in which many genes, all with a small effect, are thought to cause ...
Franke, Barbara, Faraone, Stephen V., Neale, Benjamin   +2 more
openaire   +4 more sources

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source