Results 31 to 40 of about 685,002 (338)

Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

Rice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei, Ryokei Tanaka, Taiji Kawakatsu, Shota Teramoto, Nobuhiro Tanaka, Matthew Shenton, Yusaku Uga, Shiori Yabe   +7 more
doaj   +1 more source

Genome-wide association studies in mice [PDF]

Nature Reviews Genetics, 2012
Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice.
Flint, J, Eskin, E
openaire   +4 more sources

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Human Genomics, 2019
Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper, Brian A. Walker, Walter M. Gregory, Per Hoffmann, Graham H. Jackson, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Markus Hansson, Martin Kaiser, Pieter Sonneveld, Hartmut Goldschmidt, Kari Stefansson, Kari Hemminki, Björn Nilsson, Gareth J. Morgan, Richard S. Houlston   +28 more
doaj   +1 more source

Genome-wide association study of Tourette Syndrome [PDF]

, 2014
Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we
Anderson, Kelley, Barr, Cathy L, Benarroch, Fortu, Berrío, Gabriel Bedoya, Bruun, Ruth D., Budman, Cathy L., Campbell, Desmond, Cath, Danielle C, Chouinard, Sylvain, Conti, David V., Cox, Nancy J., Crane, Jacquelyn, Crenshaw, Andrew T., Davarya, Sarah, Davis, Lea K, Dion, Yves, Duarte, Ana V. Valencia, Edlund, Christopher K., Erenberg, Gerald, Eskin, Eleazar, Evans, Patrick, Fagerness, Jesen A, Fernandez, Thomas, Fournier, Eduardo, Freimer, Nelson, Gamazon, Eric, Gibbs, J. Raphael, Gilbert, Donald L., Girard, Simon, Grados, Marco A., Gross-Tsur, Varda, Han, Buhm, Hardy, John, Heiman, Gary A., Herrera, Luis Diego, Heutink, Peter, Hoekstra, Pieter J., Illmann, Cornelia, Jankovic, Joseph, Kidd, Judith R., Kidd, Kenneth K., King, Robert A., Knowles, James A., Konkashbaev, Anuar, Kremeyer, Barbara, Kurlan, Roger, Leckman, James F., Lee, Paul C, Leppert, Mark, Liu, Chunyu, Lowe, Thomas L., Lyon, Gholson J, Mathews, Carol A., McMahon, William, Mirel, Daniel B., Moessner, Rainald, Moorjani, Priya, Morgan, Jubel, Muller, Heike, Naarden, Allan L, Neale, Benjamin M., Ochoa, William Cornejo, Oostra, Ben A., Ophoff, Roel, Osiecki, Lisa, Pakstis, Andrew J., Parkin, Melissa A., Pauls, David L., Phan, Nam, Pluzhnikov, Anna, Pollak, Yehuda, Posthuma, Danielle, Purcell, Shaun, Rangel-Lugo, Martha, Restrepo, Sandra C. Mesa, Reus, Victor I., Robertson, Mary M., Romero, Roxana, Rouleau, Guy A., Ruiz-Linares, Andres, Sabatti, Chiara, Sandor, Paul, Scharf, Jeremiah M., Service, Susan, Silgado, Julio C. Cardona, Singer, Harvey, Singleton, Andrew, Smit, Jan H, State, Matthew, Stewart, S. Evelyn, Strengman, Eric, Tikhomirov, Anna, Tischfield, Jay A., Wagner, Michael, Walkup, John, Weiss, Nicholas, Weiss, Robert, Yu, Dongmei   +97 more
core   +1 more source

Genome-wide association studies in Plasmodiumspecies [PDF]

BMC Biology, 2010
Abstract Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity.
Penman, Bridget, Buckee, Caroline, Gupta, Sunetra, Nee, Sean   +3 more
openaire   +6 more sources

Guidelines for Genome-Wide Association Studies

PLoS Genetics, 2012
Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Scott M. Williams, Gregory P. Copenhaver, Gregory S. Barsh, Greg Gibson   +3 more
openaire   +5 more sources

Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease

Nature Genetics, 2009
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the ...
J. Simón-Sánchez, C. Schulte, J. Bras, Manu Sharma, J. R. Gibbs, Daniela Berg, C. Paisán-Ruiz, Peter Lichtner, S. Scholz, Dena G. Hernandez, R. Krüger, Monica Federoff, C. Klein, A. Goate, J. Perlmutter, Michael Bonin, Mike A. Nalls, T. Illig, C. Gieger, H. Houlden, M. Steffens, M. S. Okun, B. Racette, M. Cookson, K. Foote, Hubert H. Fernandez, Bryan J Traynor, S. Schreiber, S. Arepalli, Ryan R. Zonozi, Katrina Gwinn, M. V. D. Brug, Grisel Lopez, S. Chanock, A. Schatzkin, Yikyung Park, A. Hollenbeck, Jianjun Gao, Xuemei Huang, Nick W. Wood, D. Lorenz, G. Deuschl, Honglei Chen, Olaf Riess, John Hardy, A. Singleton, T. Gasser   +46 more
semanticscholar   +1 more source

Genome-wide association study of Tourette's syndrome [PDF]

Molecular Psychiatry, 2012
Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry ...
Barbara Kremeyer, Barbara Kremeyer, Carol A. Mathews, Lea K. Davis, R. Kurlan, Robert B. Weiss, S. C. Mesa Restrepo, J.R. Kidd, Danielle Posthuma, Danielle Posthuma, Dongmei Yu, Jay A. Tischfield, Michael Wagner, Daniel B. Mirel, Yehuda Pollak, Kenneth K. Kidd, Varda Gross-Tsur, David L. Pauls, Gerald Erenberg, Eskin E, AB Singleton, Pieter J. Hoekstra, Pieter J. Hoekstra, Cathy L. Budman, Cathy L. Budman, Andrew Crenshaw, Nelson B. Freimer, Marco A. Grados, Priya Moorjani, Priya Moorjani, Christopher K. Edlund, Jeremiah M. Scharf, Jeremiah M. Scharf, S. Davarya, S. E. Stewart, S. E. Stewart, Roxana Romero, Ben A. Oostra, Robert A. King, Eric R. Gamazon, Donald L. Gilbert, Gholson J. Lyon, Gholson J. Lyon, James F. Leckman, Rainald Moessner, Anna Tikhomirov, Eduardo Fournier, Desmond Campbell, Desmond Campbell, William Cornejo Ochoa, Fortu Benarroch, Anuar Konkashbaev, John T. Walkup, James A. Knowles, Gary A. Heiman, K. Anderson, Andres Ruiz-Linares, Victor I. Reus, Nicholas T. Weiss, J.H. Smit, Sylvain Chouinard, Martha Rangel-Lugo, Chiara Sabatti, John Hardy, Danielle C. Cath, Danielle C. Cath, Gabriel Bedoya Berrío, Thomas V. Fernandez, Melissa Parkin, Thomas L. Lowe, Matthew W. State, Peter Heutink, Buhm Han, Shaun Purcell, Shaun Purcell, Shaun Purcell, Roel A. Ophoff, Roel A. Ophoff, Lisa Osiecki, Patrick Evans, Eric Strengman, Eric Strengman, N. Phan, Harvey S. Singer, Nancy J. Cox, Chunyu Liu, Cornelia Illmann, Anna Pluzhnikov, Paul Sandor, Benjamin M. Neale, Benjamin M. Neale, Jacquelyn Crane, Jesen Fagerness, P. C. Lee, H. Müller, Jubel Morgan, Cathy L. Barr, J. R. Gibbs, J. C. Cardona Silgado, Yves Dion, David V. Conti, Mark Leppert, A. V. Valencia Duarte, A. V. Valencia Duarte, Luis Diego Herrera, Allan L. Naarden, William M. McMahon, Joseph Jankovic, Guy A. Rouleau, Simon Girard, A.J. Pakstis, Mary M. Robertson, Mary M. Robertson, Ruth D. Bruun, Ruth D. Bruun   +114 more
openaire   +10 more sources

Selecting Closely-Linked SNPs Based on Local Epistatic Effects for Haplotype Construction Improves Power of Association Mapping

G3: Genes, Genomes, Genetics, 2019
Genome-wide association studies (GWAS) have gained central importance for the identification of candidate loci underlying complex traits. Single nucleotide polymorphism (SNP) markers are mostly used as genetic variants for the analysis of genotype ...
Fang Liu, Renate H. Schmidt, Jochen C. Reif, Yong Jiang   +3 more
doaj   +1 more source

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. [PDF]

, 2017
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability.
Banda, Yambazi, Choquet, Hélène, Hoffmann, Thomas J, Jorgenson, Eric, Kvale, Mark N, Melles, Ronald, Nair, K Saidas, Risch, Neil, Schaefer, Catherine, Thai, Khanh K, Yin, Jie   +10 more
core   +3 more sources