Results 41 to 50 of about 1,051,148 (367)
Genetic differences according to onset age and lung function in asthma: A cluster analysis
Clinical and Translational Allergy, 2023 Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim +11 more
doaj +1 more source
Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease
Nature Genetics, 2009 We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the ...
J. Simón-Sánchez +51 more
semanticscholar +1 more source
Guidelines for Genome-Wide Association Studies
PLoS Genetics, 2012 Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Scott M. Williams +3 more
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Genome-wide association study of Tourette's syndrome [PDF]
Molecular Psychiatry, 2012 Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry ...
Barbara Kremeyer +114 more
openaire +10 more sources
Genome-wide association study of Tourette Syndrome [PDF]
, 2014 Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we
Anderson, Kelley +97 more
core +1 more source
Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]
Genomics & Informatics, 2014 Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj +1 more source
G3: Genes, Genomes, Genetics, 2019 Genome-wide association studies (GWAS) have gained central importance for the identification of candidate loci underlying complex traits. Single nucleotide polymorphism (SNP) markers are mostly used as genetic variants for the analysis of genotype ...
Fang Liu +3 more
doaj +1 more source
Genomic partitioning of growth traits using a high-density single nucleotide polymorphism array in Hanwoo (Korean cattle) [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective The objective of this study was to characterize the number of loci affecting growth traits and the distribution of single nucleotide polymorphism (SNP) effects on growth traits, and to understand the genetic architecture for growth traits in ...
Mi Na Park +9 more
doaj +1 more source
Nature Genetics, 2015 Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering ...
F. Grassmann, Shritoma Sengupta
semanticscholar +1 more source
Brain Sciences, 2016 This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a ...
Mackenzie J. Lind, Philip R. Gehrman
doaj +1 more source