Results 41 to 50 of about 1,303,219 (221)
Genetic differences according to onset age and lung function in asthma: A cluster analysis
Clinical and Translational Allergy, 2023 Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim +11 more
doaj +1 more source
Genomic partitioning of growth traits using a high-density single nucleotide polymorphism array in Hanwoo (Korean cattle) [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective The objective of this study was to characterize the number of loci affecting growth traits and the distribution of single nucleotide polymorphism (SNP) effects on growth traits, and to understand the genetic architecture for growth traits in ...
Mi Na Park +9 more
doaj +1 more source
Genome-wide association studies in cancer [PDF]
Human Molecular Genetics, 2008 Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F. Easton +2 more
openaire +3 more sources
Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]
Genomics & Informatics, 2014 Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj +1 more source
Genome-wide association studies with metabolomics [PDF]
Genome Medicine, 2012 Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of previously undetected ...
openaire +4 more sources
Genome-Wide Association Studies of Cancer [PDF]
Journal of Clinical Oncology, 2010 Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Mark E. Robson +9 more
openaire +2 more sources
Successes of Genome-wide Association Studies [PDF]
Cell, 2010 In a recent Essay in Cell, McClellan and King argue that genomic resequencing rather than genome-wide association studies (GWAS) will be necessary to understand the genetic basis of common disease (McClellan and King, 2010). Like the authors, we too are excited about the potential for emerging sequencing technologies to facilitate discoveries that ...
Robert J. Klein +4 more
openaire +2 more sources
Evolutionary Applications, 2022 Routine implementation of genomic information for guiding selection decisions is not yet common in the majority of aquaculture species. Reduced representation sequencing approaches offer a cost‐effective solution for obtaining genome‐wide information in ...
Christos Palaiokostas +5 more
doaj +1 more source
Statistical methods to detect pleiotropy in human complex traits [PDF]
Open Biology, 2017 In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits, has become a widely researched field in human genetics. With the increasing availability of genome-wide association study summary statistics, as well as the ...
Sophie Hackinger, Eleftheria Zeggini
doaj +1 more source
Dissecting the genetic heterogeneity of gastric cancerResearch in context
EBioMedicine, 2023 Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.
Timo Hess +133 more
doaj