Results 61 to 70 of about 685,002 (338)

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium. [PDF]

, 2019
ObjectivePopulations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate ...
Chen, Yii-Der I, Fingerlin, Tasha E, Goodarzi, Mark O, Guo, Xiuqing, Langefeld, Carl D, Norris, Jill M, Palmer, Nicholette D, Raffel, Leslie J, Rotter, Jerome I, Taylor, Kent D, Wagenknecht, Lynne E, Wang, Nan, Watanabe, Richard M, Williams, Adrienne H, Xiang, Anny H, Young, Kendra A   +15 more
core   +2 more sources

Genome-wide association studies with metabolomics [PDF]

Genome Medicine, 2012
Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of previously undetected ...
openaire   +4 more sources

Genetic differences according to onset age and lung function in asthma: A cluster analysis

Clinical and Translational Allergy, 2023
Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Tae‐Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. Adcock, Kian Fan Chung, Tae‐Bum Kim, Bermseok Oh   +11 more
doaj   +1 more source

A genome-wide association study of self-rated health [PDF]

, 2010
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups.
Gordon, Scott D, Heath, Andrew C, Madden, Pamela A, Martin, Nicholas G, Medland, Sarah E, Montgomery, Grant W, Mosing, Miriam A, Painter, Jodie, Verweij, Karin J.H.   +8 more
core   +2 more sources

Genome-wide association studies in cancer [PDF]

Human Molecular Genetics, 2008
Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F. Easton, Rosalind A. Eeles, Rosalind A. Eeles   +2 more
openaire   +3 more sources

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances [PDF]

, 2013
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study ...
Alexei I. Zhurov, Anja Taanila, Anneli Pouta, Arshed M. Toma, Bakrania, Bayés de Luna, Beate St Pourcain, Bei, Bjarke Feenstra, Clive J. Hoggart, Cole, Cornelis, David M. Evans, Demetris Pillas, Di Cello, Eleftherohorinou, Eleftherohorinou, Elks, Ellen A. Nohr, Frank Geller, Freedman, Fujiwara, Geller, George Davey Smith, Ghazaleh Fatemifar, Golding, Goyal, Gu, Gudbjartsson, Hammarsund, Haraguchi, Hikake, Holmans, Horikoshi, Houlston, Hughes, Inga Prokopenko, Jernvall, Jia, John P. Kemp, Jon H. Tobias, Jussila, Kang, Kere, Kirsi Sipila, Lango Allen, Lavinia Paternoster, Levy, Li, Ligon, Mads Melbye, Marjo-Riitta Jarvelin, Meindl, Mikkola, Momoko Horikoshi, Mustonen, Nicholas J. Timpson, Nohr, Nunes, Nyholt, Paternoster, Pillas, Pispa, Pruim, Raija Lähdesmäki, Sabatti, Sakuraba, Simón-Sánchez, Soranzo, Srivastava, Stein, Stephen Richmond, Susan M. Ring, Taal, Taviaux, Tummers, Vainio, Vaz, Victoria J. Wright, Weedon, Willer, Wise, Yabe, Yang, Zhang   +84 more
core   +2 more sources

Successes of Genome-wide Association Studies [PDF]

Cell, 2010
In a recent Essay in Cell, McClellan and King argue that genomic resequencing rather than genome-wide association studies (GWAS) will be necessary to understand the genetic basis of common disease (McClellan and King, 2010). Like the authors, we too are excited about the potential for emerging sequencing technologies to facilitate discoveries that ...
Robert J. Klein, Semanti Mukherjee, James E. Hayes, Xing Xu, Jason A. Willis   +4 more
openaire   +2 more sources

A genomic‐based vision on the genetic diversity and key performance traits in selectively bred Arctic charr (Salvelinus alpinus)

Evolutionary Applications, 2022
Routine implementation of genomic information for guiding selection decisions is not yet common in the majority of aquaculture species. Reduced representation sequencing approaches offer a cost‐effective solution for obtaining genome‐wide information in ...
Christos Palaiokostas, Anam Anjum, Henrik Jeuthe, Khrystyna Kurta, Fernando Lopes Pinto, Dirk Jan deKoning   +5 more
doaj   +1 more source

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Nature Genetics, 2016
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology.
K. D. de Lange, L. Moutsianas, James C. Lee, C. Lamb, Yang Luo, N. Kennedy, L. Jostins, D. Rice, Javier Gutiérrez-Achury, S. Ji, G. Heap, E. Nimmo, C. Edwards, P. Henderson, C. Mowat, J. Sanderson, J. Satsangi, A. Simmons, D. Wilson, M. Tremelling, A. Hart, C. Mathew, W. Newman, M. Parkes, C. Lees, H. Uhlig, C. Hawkey, N. Prescott, T. Ahmad, J. Mansfield, C. Anderson, J. Barrett   +31 more
semanticscholar   +1 more source

Genome-wide association study of endometrial cancer in E2C2 [PDF]

, 2013
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women.
Alison M. Dunning, Amanda B. Spurdle, Amanda Black, Anthony M. Magliocco, Brian E. Henderson, Carlotta Sacerdote, Christine M. Friedenreich, Christopher Haiman, Chu Chen, Constance Chen, David J. Hunter, David VanDen Berg, Deborah Thompson, Douglas F. Easton, Elizabeth Holliday, Fredrick Schumacher, Hannah P. Yang, Harvey Risch, Herbert Yu, Immaculata De Vivo, Irene Orlow, Jennifer Doherty, Jennifer Prescott, Jirong Long, Jodie N. Painter, John Attia, Jolanta Lissowska, Linda S. Cook, Lingeng Lu, Loic Le Marchand, Loreall Pooler, Louise Brinton, Lucy Xia, Mark McEvoy, Marta Crous-Bou, Mia M. Gaudet, Montserrat Garcia-Closas, Nicolas Wentzensen, Noel S. Weiss, null null, Pamela L. Horn-Ross, Patricia Hartge, Peter Kraft, Radhai Rastogi, Rodney J. Scott, Sara H. Olson, Stephen Chanock, Susan E. Hankinson, Timothy R. Rebbeck, Tracy A. O’Mara, Veronica Wendy Setiawan, Wei Zheng, Xiao-ou Shu, Xiaolin Liang, Xin Sheng, Yong-Bing Xiang   +55 more
core   +1 more source