Results 61 to 70 of about 673,971 (253)

Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

Animals, 2020
The Pelibuey sheep has adaptability to climatic variations, resistance to parasites, and good maternal ability, whereas some ewes present multiple births, which increases the litter size in farm sheep.
Wilber Hernández-Montiel, Mario Alberto Martínez-Núñez, Julio Porfirio Ramón-Ugalde, Sergio Iván Román-Ponce, Rene Calderón-Chagoya, Roberto Zamora-Bustillos   +5 more
doaj   +1 more source

Genome-Wide Association Study Identifies Candidate Loci Associated with Platelet Count in Koreans [PDF]

Genomics & Informatics, 2014
Platelets are derived from the fragments that are formed from the cytoplasm of bone marrow megakaryocytes-small irregularly shaped anuclear cells. Platelets respond to vascular damage, contracts blood vessels, and attaches to the damaged region, thereby ...
Ji Hee Oh, Yun Kyoung Kim, Sanghoon Moon, Young Jin Kim, Bong-Jo Kim   +4 more
doaj   +1 more source

Association between human blood metabolome and the risk of delirium: a Mendelian Randomization study

Frontiers in Endocrinology
BackgroundDelirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads to escalated healthcare expenditures, extended hospital stays, and enduring cognitive deterioration, all of which ...
Chubing Long, Chubing Long, Dong Lin, Dong Lin, Lieliang Zhang, Lieliang Zhang, Yue Lin, Yue Lin, Qing Yao, Qing Yao, Guangyong Zhang, Guangyong Zhang, Longshan Li, Longshan Li, Hailin Liu, Hailin Liu, Jun Ying, Jun Ying, Xifeng Wang, Xifeng Wang, Fuzhou Hua, Fuzhou Hua   +21 more
doaj   +1 more source

Characterization of Insect Resistance Loci in the USDA Soybean Germplasm Collection Using Genome-Wide Association Studies

Frontiers in Plant Science, 2017
Management of insects that cause economic damage to yields of soybean mainly rely on insecticide applications. Sources of resistance in soybean plant introductions (PIs) to different insect pests have been reported, and some of these sources, like for ...
Hao-Xun Chang, Glen L. Hartman
doaj   +1 more source

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Diabetes, 2017
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using ...
R. Scott, L. Scott, R. Mägi, L. Marullo, K. Gaulton, M. Kaakinen, N. Pervjakova, T. Pers, Andrew D. Johnson, J. Eicher, A. Jackson, T. Ferreira, Yeji Lee, Clement Ma, V. Steinthorsdottir, G. Thorleifsson, L. Qi, Natalie R. van Zuydam, A. Mahajan, Han Chen, P. Almgren, B. Voight, H. Grallert, M. Müller-Nurasyid, J. Ried, N. W. Rayner, N. Robertson, L. Karssen, E. V. van Leeuwen, Sara M. Willems, C. Fuchsberger, P. Kwan, Tanya M. Teslovich, Pritam Chanda, Man Li, Yingchang Lu, C. Dina, Dorothée Thuillier, L. Yengo, Longda Jiang, T. Sparsø, H. Kestler, H. Chheda, L. Eisele, S. Gustafsson, Mattias Frånberg, R. Strawbridge, R. Benediktsson, Á. Hreidarsson, A. Kong, G. Sigurðsson, N. Kerrison, J. Luan, L. Liang, T. Meitinger, M. Roden, B. Thorand, T. Esko, E. Mihailov, C. Fox, Ching‐Ti Liu, Denis Rybin, B. Isomaa, V. Lyssenko, T. Tuomi, D. Couper, J. Pankow, N. Grarup, C. Have, M. Jørgensen, T. Jørgensen, A. Linneberg, M. Cornelis, R. V. van Dam, D. Hunter, P. Kraft, Qi Sun, S. Edkins, K. Owen, J. Perry, A. Wood, E. Zeggini, Juan Tajes-Fernandes, G. Abecasis, L. Bonnycastle, P. Chines, H. Stringham, H. Koistinen, L. Kinnunen, B. Sennblad, Thomas W. Mühleisen, M. Nöthen, S. Pechlivanis, D. Baldassarre, K. Gertow, S. Humphries, E. Tremoli, N. Klopp, Julia Meyer, G. Steinbach, R. Wennauer, J. Eriksson, S. Mӓnnistö, L. Peltonen, E. Tikkanen, G. Charpentier, Elodie Eury, S. Lobbens, B. Gigante, K. Leander, O. Mcleod, E. Bottinger, O. Gottesman, D. Ruderfer, M. Blüher, P. Kovacs, Anke Tonjes, N. Maruthur, C. Scapoli, R. Erbel, K. Jöckel, S. Moebus, U. de Faire, A. Hamsten, M. Stumvoll, P. Deloukas, P. Donnelly, T. Frayling, A. Hattersley, S. Ripatti, V. Salomaa, N. Pedersen, B. Boehm, R. Bergman, F. Collins, K. Mohlke, J. Tuomilehto, T. Hansen, O. Pedersen, I. Barroso, L. Lannfelt, E. Ingelsson, L. Lind, C. Lindgren, S. Cauchi, P. Froguel, R. Loos, B. Balkau, H. Boeing, P. Franks, A. Barricarte Gurrea, D. Palli, Y. T. van der Schouw, D. Altshuler, L. Groop, C. Langenberg, N. Wareham, E. Sijbrands, C. V. van Duijn, J. Florez, J. Meigs, E. Boerwinkle, C. Gieger, K. Strauch, A. Metspalu, A. D. Morris, C. Palmer, F. Hu, U. Thorsteinsdóttir, K. Stefánsson, J. Dupuis, Andrew P. Morris, M. Boehnke, M. McCarthy, I. Prokopenko   +174 more
semanticscholar   +1 more source

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

Nature Genetics, 2009
To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples from population-based cohorts recruited in Korea.
Y. Cho, M. Go, Y. J. Kim, J. Heo, J. Oh, H. Ban, Dankyu Yoon, Mi Hee Lee, Dong-Joon Kim, Miey Park, S. Cha, Jun-Woo Kim, B. Han, H. Min, Y. Ahn, Man Suk Park, H. Han, H. Jang, E. Cho, Jong-Eun Lee, N. Cho, C. Shin, T. Park, Ji Wan Park, Jong-Keuk Lee, L. Cardon, G. Clarke, M. McCarthy, Jong-Young Lee, Jong-Koo Lee, B. Oh, Hyung-Lae Kim   +31 more
semanticscholar   +1 more source

Genome-wide Association Studies Meet Chemoprevention [PDF]

JNCI Journal of the National Cancer Institute, 2013
The T variant at rs6983267 on 8q24 is a weakly protective allele for colorectal cancer discovered in the conduct of GWASs (2–4). This locus resides in an apparent enhancer domain for MYC (5), and deletion of the region in mice has been associated with resistance to APCmin-induced intestinal tumorigenesis (6) by decreasing TCF7L2 interaction with CTNNB1
openaire   +2 more sources

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Nature Communications, 2019
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and ...
H. Kranzler, Hang Zhou, R. Kember, Rachel Vickers Smith, A. Justice, S. Damrauer, P. Tsao, D. Klarin, A. Baras, Jeffrey Reid, J. Overton, D. Rader, Zhongshan Cheng, J. Tate, W. Becker, J. Concato, Ke Xu, R. Polimanti, Hongyu Zhao, J. Gelernter   +19 more
semanticscholar   +1 more source

Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research

Frontiers in Medicine
Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple ...
Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun   +3 more
doaj   +1 more source

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.

JAMA Neurology, 2020
Importance Large-scale genome-wide association studies in the European population have identified 90 risk variants associated with Parkinson disease (PD); however, there are limited studies in the largest population worldwide (ie, Asian). Objectives To
J. Foo, E. Chew, S. Chung, R. Peng, C. Blauwendraat, M. Nalls, K. Mok, W. Satake, T. Toda, Y. Chao, L. Tan, M. Tandiono, M. Lian, E. Ng, K. Prakash, W. Au, W. Meah, S. Mok, A. A. Annuar, Anne Y. Y. Chan, Ling Chen, Yongping Chen, B. Jeon, Lulu Jiang, Jia Lun Lim, Juei-Jueng Lin, Chunfeng Liu, C. Mao, V. Mok, Z. Pei, H. Shang, Changhe Shi, K. Song, A. Tan, Yih-Ru Wu, Yu-ming Xu, Renshi Xu, Yaping Yan, Jing Yang, Baorong Zhang, W. Koh, Shen-Yang Lim, C. Khor, Jianjun Liu, E. Tan   +44 more
semanticscholar   +1 more source