Results 71 to 80 of about 674,070 (352)

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Nature Communications, 2019
Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for ...
H. Dashti, Samuel E Jones, Andrew R. Wood, J. Lane, V. V. van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, K. Patel, Simon G Anderson, R. Beaumont, D. Bechtold, Jack Bowden, B. Cade, M. Garaulet, S. Kyle, Max A Little, A. Loudon, A. Luik, F. Scheer, K. Spiegelhalder, J. Tyrrell, Daniel J. Gottlieb, Henning Tiemeier, David W. Ray, Shaun M. Purcell, T. Frayling, S. Redline, D. Lawlor, Martin K Rutter, M. Weedon, Richa Saxena   +31 more
semanticscholar   +1 more source

Genome-Wide Association Studies in Glioma [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review, we describe a chronological history of glioma GWAS, culminating in the most recent study comprising 12,496 cases and 18,190 controls. We additionally
Kinnersley, B, Houlston, RS, Bondy, ML
openaire   +3 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.

JAMA psychiatry, 2020
Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal association ...
Hang Zhou, C. Rentsch, Zhongshan Cheng, R. Kember, Y. Nuñez, Richard Sherva, J. Tate, Cecilia Dao, Ke Xu, R. Polimanti, L. Farrer, A. Justice, H. Kranzler, J. Gelernter   +13 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

bioRxiv, 2019
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing ...
J. Revez, Tian Lin, Zhen Qiao, Angli Xue, Y. Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, J. Sidorenko, K. Kemper, A. Vinkhuyzen, J. Frater, D. Eyles, T. Burne, B. Mitchell, N. Martin, G. Zhu, P. Visscher, Jian Yang, N. Wray, J. Mcgrath   +20 more
semanticscholar   +1 more source

Multi-trait analysis for genome-wide association study of five psychiatric disorders

Translational Psychiatry, 2020
We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) ( n  = 65,967), bipolar disorder (BD) ( n  = 41,653), autism spectrum disorder (ASD) ( n  = 46,350), attention deficit hyperactivity disorder (ADHD) ( n ...
Yulu Wu, Hongbao Cao, A. Baranova, Hailiang Huang, Sheng Li, Lei Cai, Shuquan Rao, M. Dai, M. Xie, Yikai Dou, Qinjian Hao, Ling Zhu, Xiangrong Zhang, Yin Yao, Fuquan Zhang, Mingqing Xu, Qiang Wang   +16 more
semanticscholar   +1 more source

Voxelwise genome-wide association study (vGWAS) [PDF]

NeuroImage, 2010
The structure of the human brain is highly heritable, and is thought to be influenced by many common genetic variants, many of which are currently unknown. Recent advances in neuroimaging and genetics have allowed collection of both highly detailed structural brain scans and genome-wide genotype information.
Jason L, Stein, Xue, Hua, Suh, Lee, April J, Ho, Alex D, Leow, Arthur W, Toga, Andrew J, Saykin, Li, Shen, Tatiana, Foroud, Nathan, Pankratz, Matthew J, Huentelman, David W, Craig, Jill D, Gerber, April N, Allen, Jason J, Corneveaux, Bryan M, Dechairo, Steven G, Potkin, Michael W, Weiner, Paul, Thompson   +18 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

Pharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z, Li S, Yang Q, Yang X, Hao K, Liu Y, Xu S   +6 more
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