Results 71 to 80 of about 1,303,219 (221)
Genome‐wide association studies of multiple sclerosis [PDF]
Clinical & Translational Immunology, 2018 AbstractLarge‐scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, making it a prototypical common disease with complex genetic architecture. Here, after a brief historical background on the discovery and definition of the disease, we summarise the last fifteen years of genetic discoveries and map ...
Chris Cotsapas +2 more
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Associative spectra of binary operations [PDF]
Mult.-Valued Log. 5 (2000) 175-200, 2011 The distance of a binary operation from being associative can be "measured" by its associative spectrum, an appropriate sequence of positive integers. Particular instances and general properties of associative spectra are studied.
arxiv
Robust Methods for Disease-Genotype Association in Genetic Association Studies: Calculate P-values Using Exact Conditional Enumeration instead of Asymptotic Approximations [PDF]
, 2013 In genetic association studies, detecting disease-genotype associations is a primary goal. For most diseases, the underlying genetic model is unknown, and we study seven robust test statistics for monotone association. For a given test statistic, there are many ways to calculate a p-value, but in genetic association studies, calculations have ...
arxiv +1 more source
Equivariant one-parameter deformations of associative algebra morphisms [PDF]
arXiv, 2019 In this article, we introduce equivariant formal deformation theory of associative algebra morphisms. We introduce an equivariant deformation cohomology of associative algebra morphisms and using this we study the equivariant formal deformation theory of associative algebra morphisms.
arxiv
Advanced ScienceMany cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...
Wenyan Chen +14 more
doaj +1 more source
Structure and classification of Hom-associative algebras [PDF]
arXiv, 2019 The purpose of this paper is to study the structure and the algebraic varieties of Hom-associative algebras. We give characterize multiplicative simple Hom-associative algebras and show some examples deforming the $2\times 2$-matrix algebra to simple Hom-associative algebras.
arxiv
Estimating Reproducibility in Genome-Wide Association Studies [PDF]
arXiv, 2015 Genome-wide association studies (GWAS) are widely used to discover genetic variants associated with diseases. To control false positives, all findings from GWAS need to be verified with additional evidences, even for associations discovered from a high power study. Replication study is a common verification method by using independent samples.
arxiv
On the Associativity of Gluing [PDF]
J. Topol. Anal. 10 (2018), no. 3, 585-604, 2011 This paper studies the associativity of gluing of trajectories in Morse theory. We show that the associativity of gluing follows from of the existence of compatible manifold with face structures on the compactified moduli spaces. Using our previous work, we obtain the associativity of gluing in certain cases.
arxiv
eLife, 2018 Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 15,453 UL cases and 392,628 controls was performed, followed by replication of the genomic risk in six cohorts.
Niko Välimäki +17 more
doaj +1 more source
Genome-Wide Association Studies and Beyond [PDF]
Annual Review of Public Health, 2010 Genome-wide association studies (GWAS) provide an important avenue for undertaking an agnostic evaluation of the association between common genetic variants and risk of disease. Recent advances in our understanding of human genetic variation and the technology to measure such variation have made GWAS feasible.
openaire +3 more sources