Results 221 to 230 of about 42,338,399 (265)

Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1. [PDF]

PLoS One, 2018
Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K.   +22 more
europepmc   +1 more source

Integrated Multi‐Omics Analysis Reveals the Genetic Basis of Phenotypic Variation in Tibetan Sheep

Integrative Zoology, EarlyView.
SNaPshot‐validated GWAS results demonstrated significant correlations between candidate single nucleotide polymorphisms (SNPs) and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation.
Dehui Liu, Xue Li, Fei Tian, Xuexia Li, Wenxia Li, Buying Han, Ming Jiang, Yanlan Liu, Xiliu Hu, Xue Xiang, Wulong Ma, Guangcai Bao, Rong Li, Guoxiang Bao, Sijia Liu, Kai Zhao, Dehong Tian   +16 more
wiley   +1 more source

Pathway analysis with genome-wide association study (GWAS) data detected the association of atrial fibrillation with the mTOR signaling pathway. [PDF]

Int J Cardiol Heart Vasc, 2019
Ebana Y, Sun Y, Yang X, Watanabe T, Makita S, Ozaki K, Tanaka T, Arai H, Furukawa T.   +8 more
europepmc   +1 more source

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source

Identification of QTN and Candidate Gene for Seed-flooding Tolerance in Soybean [Glycine max (L.) Merr.] using Genome-Wide Association Study (GWAS). [PDF]

Genes (Basel), 2019
Yu Z, Chang F, Lv W, Sharmin RA, Wang Z, Kong J, Bhat JA, Zhao T.   +7 more
europepmc   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Joint associations of recovery capital and polygenic risk with electronic health record observed remission and relapse in substance use disorder: Longitudinal evidence from the All of Us research program

Addiction, EarlyView.
Abstract Background and aims Recovery capital and genetic liability may be related to substance use disorder (SUD) remission through psychosocial and biologic pathways, but their joint association with remission course remains poorly understood. This question is clinically important because people entering remission differ in recovery resources and ...
Janaka V. Kosgolla, Douglas C. Smith
wiley   +1 more source

Genome-wide association study (GWAS) for morphological and yield-related traits in an oil palm hybrid (Elaeis oleifera x Elaeis guineensis) population. [PDF]

BMC Plant Biol, 2019
Osorio-Guarín JA, Garzón-Martínez GA, Delgadillo-Duran P, Bastidas S, Moreno LP, Enciso-Rodríguez FE, Cornejo OE, Barrero LS.   +7 more
europepmc   +1 more source

Polygenic prediction of cannabis‐related outcomes: Evidence from the Avon Longitudinal Study of Parents and Children longitudinal cohort and the European gene–environment interaction case–control study

Addiction, EarlyView.
Abstract Background and aims Polygenic risk scores (PRSs) for cannabis use disorder (CUD), major depressive disorder (MDD), insomnia and chronic pain, and early age at cannabis initiation might be linked to problematic cannabis use. We tested whether: (1) higher PRS for CUD, MDD, insomnia and chronic pain are associated with earlier initiation and ...
Edoardo Spinazzola, Isabelle Austin‐Zimmerman, Giulia Trotta, Zhikun Li, Perry B. M. Leung, Edward Chesney, Qiang Li, Luis Alameda, Celso Arango, Michael O'Donovan, Jim van Os, Pak C. Sham, Craig Morgan, Evangelos Vassos, Diego Quattrone, Tom Freeman, Marta Di Forti, Robin M. Murray   +17 more
wiley   +1 more source

Evidence for Reduced Somatic T‐Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study

Annals of Human Genetics, EarlyView.
ABSTRACT Background The causes of late onset Alzheimer disease (LOAD) are not known but several recent lines of evidence implicate the adaptive immune system. Objective To characterize the adaptive immune system among Midwestern Amish participating in longitudinal studies of aging.
Lauren A. Cruz, Shiying Liu, Kristy L. Miskimen, Jessica N. Cooke Bailey, Tyler Kinzy, Yeunjoo E. Song, Renee A. Laux, Penelope Miron, Paula K. Ogrocki, Alan J. Lerner, Audrey Lynn, Sarada L. Fuzzell, Sherri D. Hochstetler, Ioanna Konidari, Jacob L. McCauley, William K. Scott, Margaret A. Pericak‐Vance, Jonathan L. Haines, Dana C. Crawford   +18 more
wiley   +1 more source