Results 201 to 210 of about 115,431 (259)

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source

Unveiling the BMI Risk Threshold for Osteoarthritis: Multi‐Database Causal and Nonlinear Evidence

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective To characterize the nonlinear relationship between BMI and osteoarthritis (OA), and to identify BMI thresholds that inform precise prevention strategies. Methods This multi‐database study integrated Global burden of disease 2021, National Health and Nutrition Examination Survey 2007–2018, and Genome‐Wide Association Studies.
Shaohong Yu, Li Zeng, Lei Yang, Yangjiang Ou, Chenglin Yang, Xiaoru Lin, Jingyi Shao, Qing Guan, Guobo Li, Xiuquan Lin   +9 more
wiley   +1 more source

Association of Sodium‐Glucose Cotransporter‐2 Inhibitors With Incident Gout Risk: A Population‐Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real‐world data and Mendelian randomisation (MR) analysis. Materials and Methods We
Hong Sang Choi, Jaejun Heo, Sungho Won, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Juhee Ahn, Soo Wan Kim   +7 more
wiley   +1 more source

Genetic and Environmental Effects on BMI Fluctuation Across the Adult Life Course and Its Associations With Baseline BMI and BMI Change: An Individual‐Based Study of 14 Longitudinal Twin Cohorts

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Body mass index (BMI) fluctuation has adverse health consequences, yet its determinants remain poorly understood. We examined genetic and environmental influences on BMI fluctuation and its associations with BMI trajectories. Data and Methods Data from 14 longitudinal twin cohorts, including 58 311 individuals (54% women) and 22 ...
Alvaro Obeso Fernandez, Anders Eriksson, Gabin Drouard, Aline Jelenkovic, Sari Aaltonen, Miina Ollikainen, Timothy Spector, Massimo Mangino, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Emanuela Medda, Corrado Fagnani, Robin P. Corley, Brooke M. Huibregtse, Virgilia Toccaceli, Finn E. Rasmussen, Per Tynelius, Sarah E. Medland, Scott D. Gordon, Glen E. Duncan, Dedra Buchwald, Patrik K. E. Magnusson, Ida K. Karlsson, Anna K. Dahl Aslan, Meike Bartels, Lannie Ligthart, Eco J. C. de Geus, Margaret Gatz, David A. Butler, Hyojin Pyun, Jeeeun Kim, Soo Ji Lee, Joohon Sung, Susanne Bruins, René Pool, Nicholas G. Martin, Dorret I. Boomsma, Jaakko Kaprio, Karri Silventoinen   +39 more
wiley   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Functional Genetic Variation in Ubiquitin D Promoter Influences Susceptibility to Atopic Dermatitis

Clinical &Experimental Allergy, EarlyView.
Yi Ying Eliza Lim, Yang Yie Sio, Terence Yin Weng Lam, Yee‐How Say, Kavita Reginald, Fook Tim Chew   +5 more
wiley   +1 more source

GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Clinical &Experimental Allergy, EarlyView.
M. Niemi, S. Ruotsalainen, E. Saarentaus, I. Vähätalo, F. FinnGen, I. Starskaia, T. Harju, M. Pelkonen, T. Feuth, P. Kauppi, J. Partanen, R. Lahesmaa, V. Hytönen, A. Palotie, H. Kankaanranta, T. Laitinen   +15 more
wiley   +1 more source

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Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review

Progress in Neuro-Psychopharmacology and Biological Psychiatry
Impulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue ...
Ruolei Gu, Yu L L Luo
exaly   +3 more sources

Genome-Wide Association Studies (GWAS)

2023
Most of the breeding targets are quantitative traits. In exploring the quantitative trait locus (QTL) system of a trait, linkage mapping was established using sparse polymerase chain reaction (PCR) markers. With the genome-wide sequencing technology advanced, genome-wide association study (GWAS) was developed for natural (germplasm) populations using ...
Jianbo, He, Junyi, Gai
openaire   +2 more sources