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Planning and Executing a Genome Wide Association Study (GWAS)
2009In recent years, genome-wide association approaches have proven a powerful and successful strategy to identify genetic contributors to complex traits, including a number of endocrine disorders. Their success has meant that genome wide association studies (GWAS) are fast becoming the default study design for discovery of new genetic variants that ...
Michèle M, Sale +2 more
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Genome-wide association study (GWAS) for molar–incisor hypomineralization (MIH)
Clinical Oral Investigations, 2013This genome-wide association study (GWAS) investigated the relationship between molar-incisor hypomineralization (MIH) and possible genetic loci. Clinical and genetic data from the 10-year follow-up of 668 children from the Munich GINI-plus and LISA-plus birth cohort studies were analyzed.The dental examinations included the diagnosis of MIH according ...
Jan, Kühnisch +7 more
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Validation of Genome-Wide Association Studies (GWAS) Results
2013Validation of the results of genome-wide association studies or genomic selection studies is an essential component of the experimental program. Validation allows users to quantify the benefit of applying gene tests or genomic prediction, relative to the costs of implementing the program.
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GWA-Portal: Genome-Wide Association Studies Made Easy
2018Genome-wide association studies (GWAS) are an effective method for investigating the genetics of natural phenotypic variation in many different model organisms.Here we present GWA-Portal, an interactive web application that enables researchers to upload their phenotypes and easily carry out GWAS directly in the browser.
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Building an open Genome Wide Association Study (GWAS) platform
2013 IEEE International Conference on Cluster Computing (CLUSTER), 2013We demonstrated how a flexible Genome Wide Association Study (GWAS) platform was built using the iPlant Collaborative Cyber-infrastructure. The platform is open for end users to add additional analysis tools. With the platform, customized GWAS workflows can be built in both iPlant Discovery Environment and BioExtract server.
Liya Wang +3 more
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An Introduction to Genome-Wide Association Studies: GWAS for Dummies
Seminars in Reproductive Medicine, 2016Although the genetic origin of many human diseases and phenotypes has been long and widely recognized, identification of the causative gene alleles has been limited, slow, and cumbersome. This has changed substantially with the introduction of genome-wide association studies (GWASs) a decade ago, fueled by studies and reference projects of human ...
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A Genome-Wide Association Study (GWAS) of Takotsubo syndrome
European Heart JournalAbstract Background Takotsubo syndrome (TS) is an acute cardiac condition of unknown etiology characterized by transient regional systolic dysfunction of the left and/or right ventricle. Several studies have suggested the importance of genetics; however, studies are limited and have presented ...
H F K Hakansson, P Tornvall
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Overview of Statistical Methods for Genome-Wide Association Studies (GWAS)
2013This chapter provides an overview of statistical methods for genome-wide association studies (GWAS) in animals, plants, and humans. The simplest form of GWAS, a marker-by-marker analysis, is illustrated with a simple example. The problem of selecting a significance threshold that accounts for the large amount of multiple testing that occurs in GWAS is ...
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Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review
Progress in Neuro-Psychopharmacology and Biological PsychiatryImpulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue ...
Jiaqi, Wang +4 more
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