Results 101 to 110 of about 3,563,004 (328)

The PDTIS bioinformatics platform: from sequence to function - DOI: 10.3395/reciis.v1i2.Sup.98en

RECIIS, 2007
Since the eighties, Bioinformatics has acquired a growing importance in the biological sciences. Due to the complexity of hardware and software tools, and the need for a specialized management of network infrastructure, data processing and storage, many ...
Thomas Dan Otto, Marcos Catanho, Wim Degrave, Antonio Basílio de Miranda   +3 more
doaj  

A Chromosome-Scale Genome Assembly Resource for Myriosclerotinia sulcatula Infecting Sedge Grass (Carex sp.)

Molecular Plant-Microbe Interactions, 2020
The fungus Myriosclerotinia sulcatula is a close relative of the notorious polyphagous plant pathogens Botrytis cinerea and Sclerotinia sclerotiorum but exhibits a host range restricted to plants from the Carex genus (Cyperaceae family).
Stefan Kusch, Heba M. M. Ibrahim, Catherine Zanchetta, Celine Lopez-Roques, Cecile Donnadieu, Sylvain Raffaele   +5 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Genomes

, 2012
This chapter describes the range and diversity of virus genomes. Structural and chemical diversity, ranging from small, single-stranded RNA genomes of a few kilobases up to large and complex double-stranded DNA genomes bigger than those of simple cells, is unique to viruses and not mirrored in cellular organisms.
openaire   +3 more sources

The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

eLife, 2019
The role and extent of horizontal gene transfer (HGT) in eukaryotes are hotly disputed topics that impact our understanding of the origin of metabolic processes and the role of organelles in cellular evolution.
Alessandro W Rossoni, Dana C Price, Mark Seger, Dagmar Lyska, Peter Lammers, Debashish Bhattacharya, Andreas PM Weber   +6 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

eLife, 2016
The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of developmental mechanisms and more recently regeneration. We have sequenced the genome allowing annotation of all key signaling pathways, transcription factors, and ...
Damian Kao, Alvina G Lai, Evangelia Stamataki, Silvana Rosic, Nikolaos Konstantinides, Erin Jarvis, Alessia Di Donfrancesco, Natalia Pouchkina-Stancheva, Marie Sémon, Marco Grillo, Heather Bruce, Suyash Kumar, Igor Siwanowicz, Andy Le, Andrew Lemire, Michael B Eisen, Cassandra Extavour, William E Browne, Carsten Wolff, Michalis Averof, Nipam H Patel, Peter Sarkies, Anastasios Pavlopoulos, Aziz Aboobaker   +23 more
doaj   +1 more source

Genome Sequence of Venturia oleaginea, the Causal Agent of Olive Leaf Scab

Molecular Plant-Microbe Interactions, 2020
Olive leaf scab, also known as peacock spot disease, caused by Venturia oleaginea (syn. Spilocaea oleaginea and Fusicladium oleagineum) is the most widespread and economically important fungal disease attacking olive in production countries.
Mohammed Y. Jaber, Jiandong Bao, Xiuqin Gao, Limei Zhang, Dou He, Xueyu Wang, Airong Wang, Zonghua Wang, Baohua Wang   +8 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Artificial and Natural Genetic Information Processing [PDF]

, 2017
Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core