Results 41 to 50 of about 1,891,272 (273)

Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

Nature Communications
Cis-regulatory elements (CREs), such as enhancers and promoters, are fundamental regulators of gene expression and, across different cell types, the MYC locus utilizes a diverse regulatory architecture driven by multiple CREs.
Christina M. Caragine, Victoria T. Le, Meer Mustafa, Bianca Jay Diaz, John A. Morris, Simon Müller, Alejandro Mendez-Mancilla, Evan Geller, Noa Liscovitch-Brauer, Neville E. Sanjana   +9 more
doaj   +1 more source

A molecular genome scan to map quantitative trait loci affecting bovine carcass weight [PDF]

مجله بیوتکنولوژی کشاورزی, 2009
Genome scan to map quantitative trait loci (QTL) is one of the efficient strategies for molecular dissection of complex traits. QTL mapping is the first step toward the detection of genes responsible for quantitative traits variation.
Ali Esmaeili Zade, Mohammad Reza Mohammad Abadi   +1 more
doaj   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Whole-Genome Sequence of the Trypoxylus dichotomus Japanese rhinoceros beetle [PDF]

arXiv, 2020
The draft whole-genome sequence of the Japanese rhinoceros beetle, Trypoxylus dichotomus was obtained using long-read PacBio sequence technology. The final assembled genome consisted of 739 Mbp in 2,347 contigs, with 24.5x mean coverage and a G+C content of 35.99%.
arxiv  

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Molecular Characterization of Dengue Virus Serotype 2 Cosmospolitan Genotype From 2015 Dengue Outbreak in Yunnan, China

Frontiers in Cellular and Infection Microbiology, 2018
In 2015, a dengue outbreak with 1,067 reported cases occurred in Xishuangbanna, a city in China that borders Burma and Laos. To characterize the virus, the complete genome sequence was obtained and phylogenetic, mutation, substitution and recombinant ...
Liming Jiang, Liming Jiang, Liming Jiang, Dehong Ma, Chao Ye, Chao Ye, Chao Ye, Chao Ye, Lihua Li, Xiaoman Li, Jiajia Yang, Jiajia Yang, Jiajia Yang, Yujiao Zhao, Yujiao Zhao, Yujiao Zhao, Juemin Xi, Juemin Xi, Juemin Xi, Xiaodan Wang, Xiaodan Wang, Xiaodan Wang, Junying Chen, Junying Chen, Junying Chen, Yue Pan, Yue Pan, Yue Pan, Xiyun Shan, Qiangming Sun, Qiangming Sun, Qiangming Sun   +31 more
doaj   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Genome and Environmental Activity of a Chrysochromulina parva Virus and Its Virophages

Frontiers in Microbiology, 2019
Some giant viruses are ecological agents that are predicted to be involved in the top-down control of single-celled eukaryotic algae populations in aquatic ecosystems.
Joshua M. A. Stough, Natalya Yutin, Yuri V. Chaban, Mohammed Moniruzzaman, Eric R. Gann, Helena L. Pound, Morgan M. Steffen, Jenna N. Black, Eugene V. Koonin, Steven W. Wilhelm, Steven M. Short   +10 more
doaj   +1 more source