BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]
, 2016 Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien +7 more
core +2 more sources
PLINK: a tool set for whole-genome association and population-based linkage analyses.
American Journal of Human Genetics, 2007 Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools are not designed to handle such large data sets in a convenient manner and do not necessarily exploit ...
S. Purcell +10 more
semanticscholar +1 more source
The complete sequence of a human genome
bioRxiv, 2021 In 2001, Celera Genomics and the International Human Genome Sequencing Consortium published their initial drafts of the human genome, which revolutionized the field of genomics.
S. Nurk +98 more
semanticscholar +1 more source
100K Pathogen Genome Project. [PDF]
, 2017 The 100K Pathogen Genome Project is producing draft and closed genome sequences from diverse pathogens. This project expanded globally to include a snapshot of global bacterial genome diversity.
Weimer, Bart C
core +1 more source
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
BMC Bioinformatics, 2011 BackgroundRNA-Seq is revolutionizing the way transcript abundances are measured. A key challenge in transcript quantification from RNA-Seq data is the handling of reads that map to multiple genes or isoforms.
Bo Li, Colin N. Dewey
semanticscholar +1 more source
Genomic Characterization of the Periwinkle Leaf Yellowing (PLY) Phytoplasmas in Taiwan
Frontiers in Microbiology, 2019 The periwinkle leaf yellowing (PLY) disease was first reported in Taiwan in 2005. This disease was caused by an uncultivated bacterium in the genus “Candidatus phytoplasma.” In subsequent years, this bacterium was linked to other plant diseases and ...
Shu-Ting Cho +2 more
doaj +1 more source
Little skate genome provides insights into genetic programs essential for limb-based locomotion
eLife, 2022 The little skate Leucoraja erinacea, a cartilaginous fish, displays pelvic fin driven walking-like behavior using genetic programs and neuronal subtypes similar to those of land vertebrates.
DongAhn Yoo +11 more
doaj +1 more source
Formulating genome-scale kinetic models in the post-genome era. [PDF]
, 2008 The biological community is now awash in high-throughput data sets and is grappling with the challenge of integrating disparate data sets. Such integration has taken the form of statistical analysis of large data sets, or through the bottom-up ...
Jamshidi, Neema, Palsson, Bernhard Ø
core +2 more sources
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
J. Comput. Biol., 2012 The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome ...
A. Bankevich +15 more
semanticscholar +1 more source
Non-contiguous finished genome sequence and description of Streptococcus varani sp. nov.
New Microbes and New Infections, 2016 Strain FF10T (= CSUR P1489 = DSM 100884) was isolated from the oral cavity of a lizard (Varanus niloticus) in Dakar, Senegal. Here we used a polyphasic study including phenotypic and genomic analyses to describe the strain FF10T.
S. Bakour +9 more
doaj +1 more source