Results 151 to 160 of about 1,597,445 (261)

Pan-genome analysis and phylogenetic characterization of <i>Klebsiella pneumoniae</i> from global isolates. [PDF]

Future Microbiol
Niyazi HA, Niyazi HA, AbdulMajed H, Juma N, Helmi N, Alqarni M, Saleh BH, Zubair M, Alfadil A, Alhazmi W, Alharbi OS, Halabi WS, Altalhi R, Moglad E, Alharbi MT, Gazzaz M, Alharthi TM, Altayb HN, Ibrahem K.   +18 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Fifteen Years of the Genome Analysis Toolkit as the De Facto Standard in Short-Read Variant Calling. [PDF]

Int J Mol Sci
Blazyte A, Le L, Lee J, Bayarsaikhan D, Lee B.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pan-genome analysis of soybean terpene synthase identifies <i>GmTPS20</i> as a defense-related linalool synthase. [PDF]

Front Plant Sci
Han T, Liu H, Lu T, Jiang C, Wang C, Miao G.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

EBV genome analysis in multiple sclerosis shows extensive viral diversity and links to autoimmunity. [PDF]

NAR Mol Med
Lehikoinen J, Hannolainen L, Rautila OS, Dickson ZW, Pyöriä L, Dieterich L, Jansson L, Tammi S, Hedman K, Perdomo MF, Tienari PJ.   +10 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comparative chloroplast genome analysis of Polygala species: insights into evolution, phylogeny, and DNA barcoding. [PDF]

Planta
Gülmez İ, Dönmez AA, Aydın ZU.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source