Results 91 to 100 of about 1,440,487 (305)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Regional regulation of transcription in the chicken genome [PDF]

, 2010
Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Bastiaansen John WM, Nie, H., Nie Haisheng, Crooijmans, R.P.M.A., Groenen, M.A.M., Groenen Martien AM, Bastiaansen, J.W.M., Crooijmans Richard PMA, Megens, H.J.W.C., Megens Hendrik-Jan   +9 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Annotation compatibility working group report [PDF]

, 2006
This report explores the question of compatibility between annotation projects including translating annotation formalisms to each other or to common forms. Compatibility issues are crucial for systems that use the results of multiple annotation projects.
Fang, Alex Chengyu, Contributors A. Meyers, Kübler, Sandra, Palmer, Martha, H. Zinsmeister, Hinrichs, Erhard, Schuler, Karin Kipper, G. Penn, A. C. Fang, E. Loper, M. Poesio, T. Jia-lin, Pustejovsky, James, E. Hovy, E. Hinrichs, L. Levin, B. A. Onyshkevych, Hajicova, Eva, Dorr, Bonnie, N. Xue, Hovy, Ed, Farwell, David, Ferro, Lisa, M. Palmer, Levin, Lori, Meyers, Adam, B. Dorr, D. Farwell, Jia-Lin, Tsai, Wiebe, Janyce, J. Pustejovsky, Poesio, Massimo, Loper, Edward, Onyshkevych, Boyan A., Zinsmeister, Heike, Xue, Nianwen, E. Hajicova, L. Ferro, J. Wiebe, Penn, Gerald, A. Meyers, Dolbey, Andrew, S. Kübler, K. K. Schuler, A. Dolbey   +44 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Genome sequence of the Chlamydophila abortus variant strain LLG [PDF]

, 2011
Chlamydophila abortus is a common cause of ruminant abortion. Here we report the genome sequence of strain LLG, which differs genotypically and phenotypically from the wild-type strain S26/3.
Clark, Ewan M., Smith, David George Emslie, Longbottom, D., David G. E. Smith, Spalding, L., Livingstone, M., Vretou, E., Clark, E.M., David Longbottom, Longbottom, David, Lainson, Alex F., Lainson, F.A., Victoria I. Siarkou, Wheelhouse, Nick M., Morag Livingstone, Spalding, Lucy, Wheelhouse, Nick, Lainson, F Alex, Michelle Sait, Wheelhouse, N., Lucy Spalding, Siarkou, Victoria I, Sait, M., Ewan M. Clark, F. Alex Lainson, Siarkou, V.I., Evangelia Vretou, Siarkou, Victoria I., Smith, David, Sait, Michelle, Clark, Ewan M, Nick Wheelhouse, Livingstone, Morag, Smith, David G E, Smith, D.G.E., Vretou, Evangelia   +35 more
core   +1 more source

Approaches to Fungal Genome Annotation

Mycology, 2011
Fungal genome annotation is the starting point for analysis of genome content. This generally involves the application of diverse methods to identify features on a genome assembly such as protein-coding and non-coding genes, repeats and transposable elements, and pseudogenes. Here we describe tools and methods leveraged for eukaryotic genome annotation
Brian J, Haas, Qiandong, Zeng, Matthew D, Pearson, Christina A, Cuomo, Jennifer R, Wortman   +4 more
openaire   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis [PDF]

, 2011
The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici) causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat.
van de Geest, HC, Rahim Mehrabi, de Vries, Ronald P., Dehal Paramvir, Donzelli Bruno, Conde-Ferràez, Laura, Stefano F F Torriani, Kema Gert H. J., Roeland C H J van Ham, Goodwin, S. B., Lombard, V., Nap Jan P. H., Ware, SB, Henrissat, B., Cools Hans J., Waalwijk, C, Oliver, R.P., Wiebenga, A., Wittenberg, Alexander HJ, Hane, James K., Kourmpetis Yiannis, De Wit, P., Maliepaard, C., Schouten, H., Jason J. Rudd, Goodwin, SB, Donzelli, B., Sarah B Ware, Ware Sarah B., Grigoriev, I.V., Kema, GHJ, Henk J Schouten, Van der Lee, Theo AJ, Stephen B. Goodwin, Schouten, HJ, Wittenberg, A. H. J., Foster, Andrew J, Theo A. J. Van der Lee, Jan P H Nap, Churchill, A.C.L., Lindquist, Erika, Kourmpetis, Y., de Wit, P.J.G.M., Hane James K., Donzelli, B, Aerts, Andrea, Churchill, Alice CL, M’Barek, Sarrah Ben, Charles F Crane, Ponomarenko, A., Ioannis Stergiopoulos, Andrew J. Foster, Hane, J.K., Foster, A.J., Laura Conde-Ferràez, Adilson K Kobayashi, Van Der Lee, T. A. J., Bruno Donzelli, Kilian Andrzej, Wiebenga, A, Kilian, A, Bowler, J., Bristow, J., Igor V Grigoriev, Pedro M Coutinho, Wittenberg, AHJ, Zwiers, L.H., Roeland C. H. J. van Ham, Foster, Andrew J., Cools, H.J., Ware, Sarah B, Chris Maliepaard, Foster Andrew J., Dehal, P, Dehal, Paramvir, Stefano F. F. Torriani, Ware, Sara B, Jane Grimwood, van der Burgt Ate, Kourmpetis, Yiannis, Goodwin, Stephen B., Rudd Jason J., Csukai Michael, Van der Lee, TAJ, Kim E Hammond-Kosack, Bailey Andy, Cees Waalwijk, Ware, Sarah B., Andy Bailey, Canto-Canché Blondy, Kobayashi, Adilson K., van de Geest, Henri C., Conde-Ferràez, L, Lindquist, E, Nap, Jan P.H., Burt Bluhm, Kilan, Andrzej, Maliepaard, Chris, Lindquist Erika, Hans J. Cools, Aerts, A, Edda Koopmann, Stephen B Goodwin, Bowler, Judith, Tu, H., Canto-Canché, B, van der Burgt, A., M\u27Barek, Sarrah Ben, Maliepaard, C, Hammond-Kosack Kim E., Koopmann, E, Martins, Natalia, Koopmann Edda, Paramvir Dehal, Wittenberg, Alexander H. J., Waalwijk, Cees, Bowler Judith, Hammond-Kosack, K.E., Foster, AJ, Dehal, P., Gert H J Kema, Dhillon Braham, Harris Shapiro, Wiebenga, Ad, Cools, Hans J., Geest, H.C., van de, Vries, R.P., de, Kim E. Hammond-Kosack, Lombard Vincent, Torriani Stefano F. F., Grigoriev Igor V., Koopmann, Edda, Lombard, V, Kobayashi, AK, van der Burgt, A, James K Hane, Coutinho, P.M., Ponomarenko, A, Crane, Charles F., M'Barek, S., Ben, Crane, C.F., Antoniw, J, Bristow, J, Schouten, Henk J., Antoniw, John, Gert H. J. Kema, Van der Lee, Theo A. J., Martins, N., Torriani, S.F.F., Ate van der Burgt, Hank Tu, Cools, Hans J, Rudd, J. J., Churchill, ACL, Goodwin, S.B., Csukai, Michael, Coutinho, P. M., Foster, A. J., Charles F. Crane, Grigoriev, IV, Pierre De Wit, Asaf Salamov, Grimwood, J, Henk J. Schouten, Crane, C. F., Antoniw, J. F., De Wit Pierre, Stergiopoulos, I., Henri C. van de Geest, Salamov, A., Salamov Asaf, Kobayashi, A.K., Oliver, RP, Coutinho, Pedro M., Schouten, H.J., Ware, S.B., Pedro M. Coutinho, Bailey, A., Goodwin Stephen B., Grimwood Jane, Schouten Henk J., van Ham, Roeland C.H.J., Mehrabi, R, Churchill, Alice C.L., Arnold Kuzniar, Oliver, Richard P, Lee, T.A.J., van der, van Ham, Roeland CHJ, Henrissat, Bernard, Kema, G.H.J., James K. Hane, de Wit, P, Alice C L Churchill, Van der Lee, Theo A.J., Yiannis Kourmpetis, Maliepaard, C.A., Churchill, Alice C. L., Oliver, Richard P., Schmutz, Jeremy, Kobayashi Adilson K., Richard P Oliver, Alice C. L. Churchill, Kema, Gert H.J., Conde-Ferràez, L., de Vries Ronald P., Van der Lee, T.A.J., Crane Charles F., M'Barek, SB, Grimwood, Jane, Kilian, Andrzej, Antoniw, J., Maliepaard Chris, Hammond-Kosack, K. E., Martins, N, Grigoriev, Igor V, Rudd, J.J., Coutinho Pedro M., Jim Bristow, Wittenberg Alexander H. J., Nap, J.P.H., John Antoniw, van der Burgt, Ate, Henrissat, B, Torriani, SFF, Wiebenga Ad, Lombard, Vincent, Rudd, Jason J, Ad Wiebenga, van de Geest, Henri C, Andrea Aerts, Martins Natalia, Koopmann, E., Bernard Henrissat, Kuzniar Arnold, Bluhm, Burt, Shapiro, H., Donzelli, Bruno, Hans J Cools, Antoniw John, Wittenberg, Alexander H.J., Churchill, A. C. L., Bristow, Jim, Vincent Lombard, van de Geest Henri C., Shapiro, Harris, Van De Geest, H. C., Alexander H. J. Wittenberg, Hane, James K, Bowler, J.M., Henri C van de Geest, Bluhm, B., Mehrabi Rahim, Waalwijk Cees, Adilson K. Kobayashi, Nap, Jan P. H., Ham, R.C.H.J., van, Ben M'Barek Sarrah, Mehrabi, Rahim, Jeremy Schmutz, Aerts Andrea, Schouten, Henk J, Bristow Jim, Canto-Canché, B., Blondy Canto-Canché, Hammond-Kosack, Kim E, Braham Dhillon, van de Geest, H.C., Stergiopoulos Ioannis, Schmutz, J, Jason J Rudd, Bluhm, B, Hane, J. K., Van Ham, R. C. H. J., Nap, JPH, Crane, CF, Stergiopoulos, I, Alexander H J Wittenberg, Salamov, Asaf, Nap, Jan PH, van Ham, Roel C. H. J., Shapiro Harris, Schmutz, J., Michael Csukai, de Vries, RP, van Ham Roeland C. H. J., Zwiers, Lute-Harm, Torriani, Stefano F.F., Judith Bowler, Dhillon, B., Burgt, A., van der, Sarrah Ben M'barek, Salamov, A, Crane, Charles F, Kobayashi, Adilson K, Richard P. Oliver, Goodwin, Stephen B, Ponomarenko Alisa, Bowler, J, Bailey, Andy, Natalia Martins, van Ham, RCHJ, Tu Hank, Coutinho, PM, Kourmpetis, Y, Bluhm Burt, Zwiers, L-H, Hane, JK, Csukai, M, de Vries, Ronald P, M'Barek, Sarrah B., Oliver Richard P., Geest, H.G., Van der Lee Theo A. J., Cools, HJ, Alisa Ponomarenko, Aerts, A., Andrzej Kilian, Zwiers Lute-Harm, Grigoriev, Igor V., Csukai, M., Henrissat Bernard, Dhillon, Braham, Kilian, A., Wittenberg, A.H.J., Kema, Gert. H. J., Rudd, JJ, Ben M'Barek, S., Wit, P.J.G.M., de, Tu, H, Conde-Ferràez Laura, Lindquist, E., Waalwijk, C., Lute-Harm Zwiers, Erika Lindquist, Mehrabi, A., Kuzniar, A, Dhillon, B, De Wit, Pierre, Canto-Canché, Blondy, Rudd, Jason J., Ponomarenko, Alisa, Coutinho, Pedro M, Ronald P de Vries, van Ham, R.C.H.J., Andrew J Foster, Shapiro, H, Hammond-Kosack, KE, Mehrabi, R., Torriani, Stefano FF, Schmutz Jeremy, Kuzniar, A., Kema, Gert HJ, M'barek, Sarrah Ben, Bailey, AM, Hammond-Kosack, Kim E., Grimwood, J., Jan P. H. Nap, de Vries, R.P., Stergiopoulos, Ioannis, Theo A J Van der Lee, Ronald P. de Vries, Sarah B. Ware, Igor V. Grigoriev, Churchill Alice C. L., Kuzniar, Arnold, Tu, Hank, van Ham, R.C.H., Cools, H. J.   +367 more
core   +2 more sources

Gene Ontology annotation of the rice blast fungus, Magnaporthe oryzae

BMC Microbiology, 2009
Background Magnaporthe oryzae, the causal agent of blast disease of rice, is the most destructive disease of rice worldwide. The genome of this fungal pathogen has been sequenced and an automated annotation has recently been updated to Version 6 http ...
Deng Jixin, Oh Yeon, Torto-Alalibo Trudy, Ebbole Daniel J, Brown Douglas E, Meng Shaowu, Mitchell Thomas K, Dean Ralph A   +7 more
doaj   +1 more source