Results 101 to 110 of about 1,479,681 (326)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Predicting variant deleteriousness in non-human species: applying the CADD approach in mouse

BMC Bioinformatics, 2018
Background Predicting the deleteriousness of observed genomic variants has taken a step forward with the introduction of the Combined Annotation Dependent Depletion (CADD) approach, which trains a classifier on the wealth of available human genomic ...
Christian Groß, Dick de Ridder, Marcel Reinders   +2 more
doaj   +1 more source

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

bioRxiv, 2018
A precise understanding of the genomic organization into transcriptional units and their regulation is essential for our comprehension of opportunistic human pathogens and how they cause disease.
Jelle Slager, Rieza Aprianto, J. Veening
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

VAPiD: a lightweight cross-platform viral annotation pipeline and identification tool to facilitate virus genome submissions to NCBI GenBank

BMC Bioinformatics, 2019
Background With sequencing technologies becoming cheaper and easier to use, more groups are able to obtain whole genome sequences of viruses of public health and scientific importance.
Ryan C. Shean, Negar Makhsous, Graham D. Stoddard, Michelle J. Lin, Alexander L. Greninger   +4 more
doaj   +1 more source

Community annotation and bioinformatics workforce development in concert--Little Skate Genome Annotation Workshops and Jamborees [PDF]

, 2012
Qi Wang, Cecilia N. Arighi, Benjamin L. King, Shawn W. Polson, James J. Vincent, Chuming Chen, Hongzhan Huang, Brewster F. Kingham, Shallee T. Page, M. Farnum Rendino, W. Kelley Thomas, Daniel Udwary, Cathy Wu, the North East Bioinformatics Collaborative Curation Team   +13 more
openalex   +1 more source

Additional file 7 of Genome-wide annotation of protein-coding genes in pig

, 2022
Max Karlsson, Evelina Sjöstedt, Per Oksvold, Åsa Sivertsson, Jinrong Huang, María Bueno Álvez, Muhammad Arif, Xiangyü Li, Lin Lin, Jiaying Yu, Tao Ma, Fengping Xu, Peng Han, Hui Jiang, Adil Mardinoğlu, Cheng Zhang, Kalle von Feilitzen, Xun Xu, Jian Wang, Huanming Yang, Lars Bolund, Wen Zhong, Linn Fagerberg, Cecilia Lindskog, Fredrik Pontén, Jan Mulder, Yonglun Luo, Mathias Uhlén   +27 more
openalex   +1 more source

A Method for Improving the Accuracy and Efficiency of Bacteriophage Genome Annotation

International Journal of Molecular Sciences, 2019
Bacteriophages are the most numerous entities on Earth. The number of sequenced phage genomes is approximately 8000 and increasing rapidly. Sequencing of a genome is followed by annotation, where genes, start codons, and functions are putatively ...
Alicia Salisbury, Philippos K. Tsourkas
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Annotation of 2,507 Saccharomyces cerevisiae genomes

Microbiology Spectrum
Saccharomyces cerevisiae (baker’s yeast, budding yeast) is one of the most important model organisms for biological research and is a crucial microorganism in industry.
Meng Wang, Xuan Li, Xian Liu, Xiaoping Hou, Yang He, Jun-Hong Yu, Shumin Hu, Hua Yin, Bin-Bin Xie   +8 more
doaj   +1 more source